SYSTEM AND METHOD FOR MONITORING INGESTED MEDICATION VIA RF WIRELESS TELEMETRY

• US 20090009332A1
• Filed: 07/02/2008
• Published: 01/08/2009
• Est. Priority Date: 07/03/2007
• Status: Abandoned Application

• Current Assignee: Endotronix, Inc.
• Original Assignee: Endotronix, Inc.
• Inventors: Rowland, Harry D., Nunez, Anthony I.
• Application Number:
  US12/167,050
• Publication Number:
  US 20090009332A1
• Time in Patent Office: Days
• US Class Current: 340/572.100
• CPC Class Codes: A01K 11/007 Boluses
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/073 Intestinal transmitters
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/42 Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence
• CPC Class Codes: A61B 5/4833 Assessment of subject's compliance to treatment
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61D 7/00 Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals for reproduction or fertilisation A61D19/00 ; devices for implanting pellets, radon seeds or the like A61M37/0069
• CPC Class Codes: A61J 2200/30 Compliance analysis for taking medication
• CPC Class Codes: A61J 3/007 Marking tablets or the like apparatus for printing on tablets or the like B41F17/36

Abstract

A radio frequency identification (RFID) tag device for monitoring at least one of ingestion and digestion by a subject of a solid dosage form includes a substrate attachable to the solid dosage form or at least partially embedded into the surface of the solid dosage form and an RFID tag at least partially formed on the substrate. The RFID tag is configured to generate a signal and transmit the generated signal to an external receiver to facilitate monitoring at least one of ingestion and digestion by the subject of the solid dosage form.

Claims

1. A radio frequency identification (RFID) tag device for monitoring at least one of ingestion and digestion by a subject of a solid dosage form, the RFID tag device comprising:

a substrate one of attachable to the solid dosage form and at least partially embedded into an outer surface of the solid dosage form; and

an RFID tag at least partially formed on the substrate, the RFID tag configured to generate a signal and transmit the generated signal to an external receiver to facilitate monitoring at least one of ingestion and digestion by the subject of the solid dosage form.

2. An RFID tag device in accordance with claim 1 further comprising at least one coating layer applied to at least a portion of the RFID tag.

3. An RFID tag device in accordance with claim 2 wherein the at least one coating layer is one of electrically conducting and electromagnetic shielding to alter the generated signal to facilitate detection of the RFID tag.

4. An RFID tag device in accordance with claim 2 wherein the at least one coating layer disassociates from the RFID tag to indicate ingestion of the solid dosage form.

5. An RFID tag device in accordance with claim 2 further comprising at least one interfacial layer deposited onto at least one of the RFID tag and the at least one coating layer.

6. An RFID tag device in accordance with claim 1 wherein the substrate is one of electrically conducting and electromagnetic shielding to alter the generated signal to facilitate detection of the RFID tag.

7. An RFID tag device in accordance with claim 6 wherein the substrate detaches from the RFID tag within a gastrointestinal system of the subject to facilitate indicating at least one of ingestion and digestion by the subject of the solid dosage form.

8. An RFID tag device in accordance with claim 1 wherein the RFID tag is at least partially formed directly on the solid dosage form.

9. A system for monitoring at least one of ingestion and digestion by a subject of a solid dosage form, the system comprising:

a substrate one of attached to the solid dosage form and at least partially embedded into an outer surface of the solid dosage form; and

a radio frequency identification (RFID) tag device at least partially formed on the substrate, the RFID tag device comprising an RFID tag configured to generate a signal and transmit the generated signal to an external receiver to facilitate monitoring at least one of ingestion and digestion by the subject of the solid dosage form.

10. A system in accordance with claim 9 further comprising at least one coating layer applied to at least a portion of the RFID tag.

11. A system in accordance with claim 10 wherein the at least one coating layer is one of electrically conducting and electromagnetic shielding to alter the generated signal to facilitate detection of the RFID tag.

12. A system in accordance with claim 10 wherein the at least one coating layer disassociates from the RFID tag to indicate ingestion of the solid dosage form.

13. A system in accordance with claim 9 wherein the substrate is one of electrically conducting and electromagnetic shielding to alter the generated signal to facilitate detection of the RFID tag.

14. A system in accordance with claim 13 wherein the substrate detaches from the RFID tag within a gastrointestinal system of the subject to facilitate indicating at least one of ingestion and digestion by the subject of the solid dosage form.

15. A system in accordance with claim 9 wherein the RFID tag is at least partially formed directly on the solid dosage form.

16. A system in accordance with claim 15 wherein the RFID tag is one of formed on the solid dosage form and at least partially embedded into the outer surface of the solid dosage form using one of an ink jetting, screen printing, impact printing, stamping, roll-to-roll printing, contact printing, spin coating, casting, gravure printing, roll coating, gap coating, rod coating, extrusion coating, dip coating, curtain coating, and air knife coating process.

17. A system in accordance with claim 9 wherein the substrate is wrapped around the solid dosage form.

18. A method for monitoring at least one of ingestion and digestion by a subject of a solid dosage form, the method comprising:

attaching a radio frequency identification (RFID) tag to a solid dosage form; and

detecting a change in a signal generated by the RFID tag after ingestion of the solid dosage form.

19. A method for manufacturing a solid dosage form for monitoring at least one of ingestion and digestion by a subject of the solid dosage form, the method comprising:

forming an antenna on a substrate;

forming a radio frequency identification (RFID) tag including the antenna, the RFID tag configured to receive interrogation signals from an external transmitter and generate a response signal that is transmitted to an external receiver such that the response signal can be monitored; and

attaching the substrate to the solid dosage form or partially embedding the substrate into an outer surface of the solid dosage form.

20. A method in accordance with claim 19 further comprising forming a coating layer on at least a portion of the RFID tag, wherein the coating layer is one of electrically conducting and electromagnetic shielding to alter the response signal such that if the RFID tag is interrogated before the solid dosage form enters a gastrointestinal system of the subject, a first response signal generated by the RFID tag is detectable to confirm that the solid dosage form has not entered the gastrointestinal system and such that if the RFID tag is interrogated after the solid dosage form enters the gastrointestinal system, the coating layer separates from the RFID tag such that a second response signal generated by the RFID tag is detectable to confirm that the solid dosage form has entered the gastrointestinal system.

21. A method in accordance with claim 19 wherein the substrate is one of electrically conducting and electromagnetic shielding to alter the response signal such that if the RFID tag is interrogated before the solid dosage form has dispersed in a gastrointestinal system of the subject, a first response generated by the RFID tag is detectable to confirm that the solid dosage form has not dispersed in the gastrointestinal system and such that if the RFID tag is interrogated after the solid dosage form has dispersed in the gastrointestinal system, the substrate separates from the RFID tag such that a second response signal generated by the RFID tag is detectable to confirm that the solid dosage form has dispersed in the gastrointestinal system.

22. A method in accordance with claim 19 further comprising depositing an interfacial layer on at least one of the substrate, the antenna and a coating layer formed on at least a portion of the RFID tag.

23. A method in accordance with claim 19 wherein the substrate is attached to the solid dosage form using a printing process.

24. A method in accordance with claim 19 wherein a portion of the antenna is formed directly on the solid dosage form.

25. A method in accordance with claim 19 wherein the antenna is one of formed on the solid dosage form and at least partially embedded into the outer surface of the solid dosage form using one of an ink jetting, screen printing, impact printing, stamping, roll-to-roll printing, contact printing, spin coating, casting, gravure printing, roll coating, gap coating, rod coating, extrusion coating, dip coating, curtain coating, and air knife coating process.

26. A method in accordance with claim 19 further comprising:

depositing a first material layer on the solid dosage form;

patterning the first material layer; and

depositing a conducting material layer on the solid dosage form.

27. A method in accordance with claim 26 further comprising removing at least a portion of the first material layer prior to depositing the conducting material layer.

28. A method in accordance with claim 26 wherein the first material layer is patterned using one of an ink jetting, screen printing, impact printing, stamping, roll-to-roll printing, contact printing, spin coating, casting, gravure printing, roll coating, gap coating, rod coating, extrusion coating, dip coating, curtain coating, air knife coating, and laser writing process.

29. A method in accordance with claim 26 further comprising curing the first material layer after depositing the first material layer on the solid dosage form using one of thermal radiation and electromagnetic radiation.

30. A method in accordance with claim 26 wherein the conducting material layer is deposited on the solid dosage form using one of an ink jetting, screen printing, impact printing, stamping, roll-to-roll printing, contact printing, spin coating, casting, gravure printing, roll coating, gap coating, rod coating, extrusion coating, dip coating, curtain coating, air knife coating, and laser writing process.

31. A method in accordance with claim 19 further comprising wrapping the antenna about at least a portion of the solid dosage form.

32. A method in accordance with claim 19 wherein the solid dosage form is directly patterned using one of a molding, embossing, and laser writing process, and the conducting material layer is deposited on the solid dosage form.

33. A method in accordance with claim 19 wherein attaching the substrate to the solid dosage form further comprises at least partially embedding the substrate into the outer surface of the solid dosage form.