Methods related to surgery

• US 20090010899A1
• Filed: 07/02/2008
• Published: 01/08/2009
• Est. Priority Date: 03/31/2005
• Status: Active Grant

• Current Assignee: Stemnion, Inc.
• Original Assignee: Stemnion, Inc.
• Inventors: Smith, Charlotte A., Palladino, Linda O., Marshall, Vivienne S., Clarke, Diana L., Robson, Martin C.
• Granted Patent: US 8,153,430 B2
• Time in Patent Office: Days
• US Class Current: 424/93.700
• CPC Class Codes: A61K 35/50 Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The invention is directed to methods related to surgery, for example gastrointestinal surgery. In particular, the invention is methods of treating fistulae, promoting accelerated healing of anastomoses and preventing failure of anastomoses. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination.

Claims

1. A method for treating fistulae in a patient in need thereof comprising administering to the patient a therapeutically effective amount of one or more compositions comprising ECS cells, conditioned media derived therefrom, cell lysate derived therefrom or cell products derived therefrom.

2. The method of claim 1 wherein the administration occurs during surgical intervention to treat the fistulae.

6. The method of claim 1, 3 or 4 wherein the ECS cells are AMP cells.

7. The method of claim 1, 3 or 4 wherein the conditioned media is ACCS or pooled ACCS.

8. The method of claim 1, 3 or 4 wherein the ECS cells, conditioned media derived therefrom, cell lysate derived therefrom or cell products derived therefrom are administered in combination with other agents or therapies.

9. The method of claim 1, 3 or 4 wherein the ECS cells are partially differentiated or fully differentiated.

10. The method of claim 6 wherein the AMP cells are partially differentiated or fully differentiated.

3. A method for promoting accelerated healing of anastomosis in a patient in need thereof comprising administering to the patient a therapeutically effective amount of one or more compositions comprising ECS cells, conditioned media derived therefrom, cell lysate derived therefrom or cell products derived therefrom.

5. The method of claim 3 or 4 wherein the administration occurs during the surgery to create the anastomosis.

4. A method for preventing failure of anastomosis in a patient in need thereof comprising administering to the patient a therapeutically effective amount of one or more compositions comprising ECS cells, conditioned media derived therefrom, cell lysate derived therefrom or cell products derived therefrom.