Biodegradable Elastomers
First Claim
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1. An porous elastomeric composition comprising a cross-linked polyester for the proliferation of cells, the cross-linked polyester comprising:
- a polymeric unit of the general formula (-A-B—
)n cross-linked between at least a portion of the A components of the polyester, at least a portion of the cross-links forming a dioic acid ester;
wherein,A represents a substituted or unsubstituted ester,B represents a substituted or unsubstituted acid ester comprising at least two acid ester functionalities; and
n represents an integer greater than 1;
a hydrophilic polyol present in the range between about 10% to about 35% by weight with respect to the polyester; and
cells within at least a portion of the elastomeric composition.
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Abstract
The present inventions in various aspects provide elastic polymers compositions for encapsulation of cells. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked in the presence of glycerol and a population of cells to form elastic porous polymer scaffolds suitable for cell encapsulation and/or proliferation.
81 Citations
50 Claims
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1. An porous elastomeric composition comprising a cross-linked polyester for the proliferation of cells, the cross-linked polyester comprising:
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a polymeric unit of the general formula (-A-B—
)n cross-linked between at least a portion of the A components of the polyester, at least a portion of the cross-links forming a dioic acid ester;
wherein,A represents a substituted or unsubstituted ester, B represents a substituted or unsubstituted acid ester comprising at least two acid ester functionalities; and
n represents an integer greater than 1;a hydrophilic polyol present in the range between about 10% to about 35% by weight with respect to the polyester; and cells within at least a portion of the elastomeric composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. An porous elastomeric composition comprising a cross-linked polyester, the cross-linked
polyester comprising: -
a polymeric unit of the general formula (-A-B—
)n cross-linked between at least a portion of the A components of the polyester, the cross-link forming a link comprising at least a portion of the general formula -(D)k-C—
;
whereinA represents a substituted or unsubstituted ester, B represents a substituted or unsubstituted acid ester comprising at least two acid ester functionalities; C represents a substituted or unsubstituted dioic acid ester; D represents one or more of a substituted or unsubstituted ester; n represents an integer greater than 1; and k represents an integer greater than 0; and a hydrophilic polyol present in the range between about 10% to about 35% by weight with respect to the polyester; and cells within at least a portion of the elastomeric composition. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A method for forming an elastomeric material, comprising the steps of:
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(a) reacting a first component comprising two or more functionalities of the general formula —
OR, where R of each group is independently hydrogen or alkyl, with a second component comprising two or more acid ester functionalities to form a mixture of pre-polymers having a molecular weight in the range between about 300 Da and about 75,000 Da;(b) reacting the mixture of pre-polymers with an acrylate to form a mixture of acrylated pre-polymers; (c) adding between about 10% to about 35% of a hydrophilic polyol by weight with respect to the mixture of acrylated pre-polymers to form a polyol-acrylated pre-polymer mixture; (d) adding a population of cells to the polyol-acrylated pre-polymer mixture to form a cell-polymer mixture; (e) irradiating the cell-polymer mixture with ultraviolet light to cross-link at least a portion of the acrylated pre-polymers and form a biodegradable elastomeric material;
wherein the cell-polymer mixture is not heated above about 45°
C. during irradiation. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
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Specification