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Peptides and related compounds having thrombopoietic activity

  • US 20090011497A1
  • Filed: 02/19/2008
  • Published: 01/08/2009
  • Est. Priority Date: 10/11/2001
  • Status: Abandoned Application
First Claim
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1. A compound that binds to an mpl receptor comprising the sequence:


  • X1-X2-X3-X4-G-P-T-L-X9-X10-W-L-X13-X14-X15-X16-X17-X18wherein X1-X4, X9-X10, and X13-X18 are each independently an amino acid, said compound having a binding affinity for the mpl receptor greater than that of the sequence;


    X19-X20-1-E-G-P-T-L-R-Q-W-L-A-A-R-A-X21-X22,wherein X19-X20 and X21-X22 are each independently an amino acid, andphysiologically acceptable salts thereof.

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