Peptides and related compounds having thrombopoietic activity
First Claim
Patent Images
1. A compound that binds to an mpl receptor comprising the sequence:
-
X1-X2-X3-X4-G-P-T-L-X9-X10-W-L-X13-X14-X15-X16-X17-X18wherein X1-X4, X9-X10, and X13-X18 are each independently an amino acid, said compound having a binding affinity for the mpl receptor greater than that of the sequence;
X19-X20-1-E-G-P-T-L-R-Q-W-L-A-A-R-A-X21-X22,wherein X19-X20 and X21-X22 are each independently an amino acid, andphysiologically acceptable salts thereof.
0 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates generally to novel peptides and related compounds that have thrombopoietic activity. The compounds of the invention may be used to increase production of platelets or platelet precursors (e.g. megakaryocytes) in a mammal.
-
Citations
25 Claims
-
1. A compound that binds to an mpl receptor comprising the sequence:
-
X1-X2-X3-X4-G-P-T-L-X9-X10-W-L-X13-X14-X15-X16-X17-X18wherein X1-X4, X9-X10, and X13-X18 are each independently an amino acid, said compound having a binding affinity for the mpl receptor greater than that of the sequence;
X19-X20-1-E-G-P-T-L-R-Q-W-L-A-A-R-A-X21-X22,wherein X19-X20 and X21-X22 are each independently an amino acid, and physiologically acceptable salts thereof. - View Dependent Claims (3, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
-
-
2. A compound that binds to an mpl receptor comprising the sequence:
-
X1-X2-X3-X4-G-P-T-L-X9-X10-W-L-X13-X14-X15-X16-X17-X18wherein X1-X4, X9-X10, and X13-X18 are each independently an amino acid, said compound having a bioactivity greater than that of the sequence;
X19-X20-I-E-G-P-T-L-R-Q-W-L-A-A-R-A-X21-X22,wherein X19-X20 and X21-X22 are each independently an amino acid, and physiologically acceptable salts thereof. - View Dependent Claims (4)
-
-
5. A compound that binds to an mpl receptor comprising the sequence:
-
X1-X2-R-E-G-P-T-L-R-Q-W-L-X13-W-R-R-X17-X18wherein X1, X2, X13, X17 and X18 are each independently an amino acid.
-
-
6. A compound that binds to an mpl receptor comprising a sequence which is selected from the group consisting of SEQ ID NO 2 to SEQ ID NO 30, inclusive.
-
25. A compound that binds to an mpl receptor comprising the formula:
-
(V1)v-(TMP1)a-(V2)wwherein V1 and V2 are each an IgG1 Fc domain, provided that where v is one, w is zero and where v is zero, w is one and TMP1 is a peptide of SEQ ID NO 2 to 30;
a is an integer from one to twenty.
-
Specification