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Methods and devices based upon a novel form of nucleic acid duplex on a surface

  • US 20090011949A1
  • Filed: 04/04/2008
  • Published: 01/08/2009
  • Est. Priority Date: 07/11/2001
  • Status: Active Grant
First Claim
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1. A biomolecular hybridization device comprising:

  • a substrate having a surface of functional groups permanently and covalently attached thereto; and

    an adsorbed monolayer of unmodified, single-stranded oligonucleotides all of which are 10 to about 24 bases in length as a saturated film of constrained oligonucleotides on the surface via direct non-covalent phosphate-surface adsorptive contact of substantially all phosphate groups of each oligonucleotide;

    wherein each constrained oligonucleotide base plane is presented from the surface in a manner effective to dissociably hybridize to a complementary single-stranded nucleic acid with asymmetric, non-helical base pairing without alteration of the oligonucleotide base plane presentation and without oligonucleotide phosphate group dissociation from the surface.

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