Biotin-binding receptor molecules
First Claim
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1. A method for enhancing action of a drug on a cell when administered to the cell, wherein the drug is modified by biotinylation and wherein the cell is transduced to express a fusion protein comprising a membrane-spanning domain of an endocytotic receptor and an extracellular domain that comprises biotin-binding activity.
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Abstract
The subject invention pertains to a transmembrane protein capable of binding to biotinylated molecules, the protein comprising a cytoplasmic domain, a membrane-spanning domain and an extracellular domain, wherein the extracellular domain comprises biotin-binding activity, and methods of use. The protein can be expressed in a cell, thereby targeting a biotinylated drug.
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10 Claims
- 1. A method for enhancing action of a drug on a cell when administered to the cell, wherein the drug is modified by biotinylation and wherein the cell is transduced to express a fusion protein comprising a membrane-spanning domain of an endocytotic receptor and an extracellular domain that comprises biotin-binding activity.
- 6. A method for treating a disease in a patient, said method comprising administering to said patient a biotinylated molecule useful in the treatment of said disease, wherein said biotinylated molecule is targeted to a target site comprising a fusion protein comprising a membrane-spanning domain of an endocytotic receptor and an extracellular domain that comprises biotin-binding activity, and wherein said biotinylated molecule exerts its effect on said target site.
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