Inhibition of pancretic cancer cell growth
First Claim
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1. A method comprising contacting a pancreatic adenocarcinoma cell with both a Hedgehog pathway inhibitor and a Wnt pathway inhibitor, under conditions suitable for retarding growth of said pancreatic adenocarcinoma cell.
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Abstract
The present invention relates to compositions and methods for inhibition of signal transduction pathways in cancer cells. In particular, the present invention provides methods and compositions comprising Wnt and Hedgehog pathway inhibitors for reducing proliferation of adenocarcinoma cells.
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26 Claims
- 1. A method comprising contacting a pancreatic adenocarcinoma cell with both a Hedgehog pathway inhibitor and a Wnt pathway inhibitor, under conditions suitable for retarding growth of said pancreatic adenocarcinoma cell.
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11. A method of treating cancer of the pancreas, comprising:
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a) providing a Hedgehog pathway inhibitor and a Wnt pathway inhibitor; and b) administering said Hedgehog pathway inhibitor and said Wnt pathway inhibitor to a subject diagnosed with cancer of the pancreas, under conditions suitable for retarding growth of said cancer. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A kit for treating pancreatic adenocarcinoma in a subject, comprising:
- a) a Hedgehog pathway inhibitor;
b) a Wnt pathway inhibitor; and
c) instructions for using said Hedgehog pathway inhibitor and said Wnt pathway inhibitor to treat pancreatic adenocarcinoma in a subject. - View Dependent Claims (25, 26)
- a) a Hedgehog pathway inhibitor;
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