Osmotic Devices and Methods for Diuretic Therapy

• US 20090012444A1
• Filed: 07/02/2007
• Published: 01/08/2009
• Est. Priority Date: 07/02/2007
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Mokelke, Eric A., Kane, Michael John, Shuros, Allan Charles
• Granted Patent: US 8,105,261 B2
• Time in Patent Office: Days
• US Class Current: 604/6.90
• CPC Class Codes: A61B 17/12031 complete occlusion
• CPC Class Codes: A61B 17/12036 partial occlusion
• CPC Class Codes: A61B 17/12099 characterised by the location of the occluder
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/1219 expandable in contact with liquids
• CPC Class Codes: A61F 2250/0003 having an inflatable pocket filled with fluid, e.g. liquid or gas

Abstract

Embodiments of the invention are related to devices and methods for modulating renal function, amongst other things. In an embodiment, the invention includes an implantable occlusive device including a wall member defining an enclosed volume, the wall member can include a semi-permeable membrane. The device can also include a solution comprising a solvent and a solute disposed within the enclosed volume of the wall member. The semi-permeable membrane can be permeable to the solvent and impermeable to the solute. The enclosed volume can be configured to expand and contract in response to changes in the osmolality of a bodily fluid. The device can include a positioning member configured to maintain the position of the implantable occlusive device relative to a lengthwise axis of a lymphatic vessel. In an embodiment, the invention includes a method of modulating renal function in a patient including implanting an occlusive device in the patient, the occlusive device comprising a semi-permeable membrane and configured to expand or contract based on the passage of a fluid across the semi-permeable membrane. Other aspects and embodiments are provided herein.

Claims

1. An implantable occlusive device comprising:

a wall member defining an enclosed volume, the wall member comprising a semi-permeable membrane;

a solution comprising a solvent and a solute, the solution disposed within the enclosed volume; and

a positioning member, the positioning member configured to maintain the position of the implantable occlusive device relative to a lengthwise axis of a lymphatic vessel;

the semi-permeable membrane permeable to the solvent and impermeable to the solute;

the enclosed volume configured to expand in response to decreases in osmolality of a bodily fluid and contract in response to increases in osmolality of a bodily fluid.

2. The implantable occlusive device of claim 1, the semi-permeable membrane comprising a biocompatible material.

3. The implantable occlusive device of claim 1, the solute comprising at least one of sodium chloride and potassium chloride.

4. The implantable occlusive device of claim 1, the semi-permeable membrane comprising a polymer.

5. The implantable occlusive device of claim 4, the semi-permeable membrane comprising polytetrafluoroethylene.

6. The implantable occlusive device of claim 1, the wall member comprising a membrane impermeable to both the solvent and the solute.

7. The implantable occlusive device of claim 1, the positioning member comprising a rigid support member disposed around an outer perimeter of the enclosed volume.

8. The implantable occlusive device of claim 7, the rigid support member comprising an annular shape.

9. The implantable occlusive device of claim 1, further comprising an osmolality sensor configured to sense the osmolality of the solution within the enclosed volume.

10. The implantable occlusive device of claim 1, further comprising a pressure sensor configured to sense the pressure within the enclosed volume.

11. The implantable occlusive device of claim 1, the positioning member comprising a lead body coupled to the wall member.

12. The implantable occlusive device of claim 11, further comprising a conductor disposed within the lead body.

13. The implantable occlusive device of claim 1, the positioning member comprising one or more appendages configured to engage an inside surface of a renal lymphatic vessel.

14. A method of modulating renal function in a patient comprising:

implanting an occlusive device in the patient, the occlusive device comprising a semi-permeable membrane, the occlusive device configured to expand or contract based on the passage of a fluid across the semi-permeable membrane; and

occluding a renal lymphatic vessel with the occlusive device.

15. The method of claim 14, comprising implanting the occlusive device inside a renal lymphatic vessel of the patient.

16. The method of claim 14, comprising implanting the occlusive device outside of a renal lymphatic vessel of the patient.

17. The method of claim 14, the occlusive device configured to expand in response to decreases in osmolality of a bodily fluid.

18. The method of claim 14, the occlusive device configured to expand in response to decreases in osmolality of a bodily fluid within a renal lymphatic vessel.

19. The method of claim 14, the occlusive device configured to contract in response to increases in osmolality of a bodily fluid.

20. The method of claim 14, the occlusive device configured to contract in response to increases in osmolality of a bodily fluid within a renal lymphatic vessel.

21. The method of claim 14, the occlusive device defining an enclosed volume.

22. The method of claim 21, further comprising inserting a solution comprising a solvent and a solute into the enclosed volume.

23. A method of treating a hypervolemic state including heart failure decompensation and/or hypertension comprising:

implanting an occlusive device in the patient, the occlusive device comprising a semi-permeable membrane, the occlusive device configured to expand or contract based on the passage of a fluid across the semi-permeable membrane; and

occluding a renal lymphatic vessel with the occlusive device.