IMPLANT AND SYSTEM OF AN IMPLANT AND A EXCITATION DEVICE

• US 20090017088A1
• Filed: 07/11/2008
• Published: 01/15/2009
• Est. Priority Date: 07/13/2007
• Status: Active Grant

• Current Assignee: Biotronik AG (Biotronik SE & Company KG)
• Original Assignee: Biotronik VI Patent AG (Biotronik SE & Company KG)
• Inventors: Klocke, Bjoern, Fringes, Matthias, Hofmann, Eugen
• Granted Patent: US 8,337,548 B2
• Time in Patent Office: Days
• US Class Current: 424/422
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2210/0071 thermoplastic
• CPC Class Codes: A61F 2250/0001 Means for transferring electromagnetic energy to implants
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

An implant comprising a body (1), at least one active pharmaceutical substance (4) and an element (5, 15, 35, 45, 55) deflectable in relation to the body, serving to release the at least one active pharmaceutical substance (4) during or after an external excitation of the deflection. Also disclosed is a system of such an implant and an excitation device (30, 70).

Claims

1. An implant, comprising:

a) a body;

b) at least one active pharmaceutical substance; and

c) an element which is deflectable in relation to the body and which serves to release the at least one active pharmaceutical substance after or during an external triggering of the deflection.

2. The implant of claim 1, wherein the deflection is vibration of the element which persists over a predetermined period of time.

3. The implant of claim 2, wherein the frequency of the external excitation signal is coordinated with the element so that the vibration of the deflectable element is at a resonant frequency.

4. The implant of claim 2, wherein the geometry or the mass of the deflectable element is coordinated with the frequency of the external excitation signal, so that the vibration of the deflectable element is at a resonant frequency.

5. The implant of claim 1, wherein the deflectable element is at least partially either ferromagnetic or permanently magnetic and the external excitation takes place by means of a signal of an alternating magnetic field.

6. The implant of claim 1, wherein the external excitation takes place by means of an ultrasonic signal, whereby the ultrasonic signal is coordinated with the deflectable element and the body so that the deflectable element is deflected relative to the body.

7. The implant of claim 1, wherein the deflectable element is designed to be plate-shaped and preferably has at least one opening.

8. The implant of claim 1, wherein a plurality of deflectable elements is arranged to float in a layer that is provided with the at least one active pharmaceutical substance, the layer preferably being formed by a film.

9. The implant of claim 1, wherein the layer comprises a degradable film.

10. The implant of claim 1, wherein the deflectable element is provided in a recess in the body, whereby the at least one active pharmaceutical substance is arranged above or below the deflectable element.

11. The implant of claim 10, wherein the deflectable element has through-openings which are closed in the state without external excitation and are at least temporarily open in the state with external excitation and thereby release the at least one active pharmaceutical substance.

12. The implant of claim 1, wherein the deflectable element is arranged in an opening passing through the body, the opening being closed on one side by a semipermeable membrane and closed on the other side by an impermeable plastic cover, whereby the deflectable element and the at least one active pharmaceutical substance are provided between the semipermeable membrane and the plastic cover in the opening.

13. The implant of claim 12, wherein the semipermeable membrane has a pore size of in a range of from approximately 0.5 μ

m to approximately 1 μ

m.

14. A system, comprising:

a) a first implant; and

b) an excitation device preferably formed as the second implant, whereby the excitation serves to provide external excitation of deflection of the deflectable element of the first implant.

15. The system of claim 14, wherein the excitation device generates either an alternating magnetic field or an ultrasonic signal.

16. The system of claim 15, wherein the alternating magnetic field is generated by the excitation device by means of an external induction coil.

17. The system of claim 14, wherein the excitation device has a sensor unit with which at least one bodily function is measured, whereby the excitation device is designed so that an excitation signal is delivered only when at least one function of the at least one measured bodily function is in a predetermined range.

18. A system, comprising:

a) a first implant having a body and at least one active pharmaceutical substance, wherein the implant has an element which is deflectable in relation to the body and which serves to release the at least one active pharmaceutical substance after or during an external triggering of the deflection; and

b) an excitation device preferably formed as the second implant, whereby the excitation serves to provide external excitation of deflection of the deflectable element of the first implant.