Nucleic Acid Hybridization Device
First Claim
1. A nucleic acid hybridization device, comprising:
- (1) an oscillation generating unit;
(2) a spacer attached to the top of the oscillation generating unit and wraps around to form a tank, and the tank is loaded with a transmission solution;
(3) a loading plate having a loading face was paved with at least one nucleic acid probe, and the flip side of the loading face is a transmission face, which covers on the spacer to form a closed space, and is attached with the transmission solution;
(4) an attaching layer; and
(5) a reaction body connected to the loading plate with the attaching layer, the nucleic acid probes are paved to surround the inside of the reaction body, the reaction solution sits between the reaction body and the loading plate.
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Abstract
The present invention relates to a hybridization device coupled by means of vibration to shorten the time needed for hybridization. This hybridization device of the present invention comprises an oscillation generating unit; a spacer attached to the top of the oscillation generating unit, which wraps around to form a tank, and the tank is loaded with a transmission solution; a loading plate having a loading face was paved with at least one nucleic acid probe, and the flip side of the loading face is a transmission face, which covers on top of the spacer to form a closed space, and is attached with the transmission solution. The vibration generated by the oscillation generating unit can be propagated to the loading plate through the transmission solution to promote the effective mixing of the nucleic acid to be analyzed and the probe, further to shorten the time needed for nucleic acid hybridization and to increase the detection sensitivity.
6 Citations
14 Claims
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1. A nucleic acid hybridization device, comprising:
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(1) an oscillation generating unit; (2) a spacer attached to the top of the oscillation generating unit and wraps around to form a tank, and the tank is loaded with a transmission solution; (3) a loading plate having a loading face was paved with at least one nucleic acid probe, and the flip side of the loading face is a transmission face, which covers on the spacer to form a closed space, and is attached with the transmission solution; (4) an attaching layer; and (5) a reaction body connected to the loading plate with the attaching layer, the nucleic acid probes are paved to surround the inside of the reaction body, the reaction solution sits between the reaction body and the loading plate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification