SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY
First Claim
1. A compound having structural Formula 1:
- or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein;
R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, and R18 are independently selected from the group consisting of hydrogen and deuterium;
R19, R20, and R21, are independently selected from the group consisting of —
CH3 and —
CD3;
provided that compounds of Formula 1 contain at least one deuterium atom; and
provided that deuterium enrichment in compounds of Formula 1 is at least about 1%.
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Accused Products
Abstract
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.
48 Citations
29 Claims
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1. A compound having structural Formula 1:
-
or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein; R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, and R18 are independently selected from the group consisting of hydrogen and deuterium; R19, R20, and R21, are independently selected from the group consisting of —
CH3 and —
CD3;provided that compounds of Formula 1 contain at least one deuterium atom; and provided that deuterium enrichment in compounds of Formula 1 is at least about 1%. - View Dependent Claims (2, 3, 4, 27, 28, 29)
or a pharmaceutically acceptable salt, solvate, or prodrug thereof.
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3. The compound as recited in claim 1, having a structural formula selected from the group consisting of:
or a pharmaceutically acceptable salt, solvate, or prodrug thereof.
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4. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1 together with a pharmaceutically acceptable carrier.
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27. The compound as recited in claim 1, wherein said compound of Formula 1 is a mixture of about 90% or more by weight of the (+)-enantiomer and about 10% or less by weight of the (−
- )-enantiomer.
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28. The compound as recited in claim 1, wherein said compound of Formula 1 is a mixture of about 90% or more by weight of the (−
- )-enantiomer and about 10% or less by weight of the (+)-enantiomer.
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29. The compound as recited in claim 1, wherein said compound of Formula 1 is a hydrochloride salt.
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5-26. -26. (canceled)
Specification