TRACKABLE IMPLANTABLE SENSOR DEVICES, SYSTEMS, AND RELATED METHODS OF OPERATION

• US 20090018403A1
• Filed: 07/09/2008
• Published: 01/15/2009
• Est. Priority Date: 07/12/2007
• Status: Abandoned Application

• Current Assignee: VTQ IP Holding Corporation
• Original Assignee: Sicel Technologies, Inc.
• Inventors: Mann, Gregory Glenwood, Black, Robert D.
• Application Number:
  US12/170,112
• Publication Number:
  US 20090018403A1
• Time in Patent Office: Days
• US Class Current: 600/300
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61B 6/508 for non-human patients
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61N 5/1048 Monitoring, verifying, controlling systems and methods

Abstract

An implantable biocompatible sensor unit includes a sensor body of a biocompatible material configured for in vivo placement proximate a tumor treatment site. The sensor body includes at least one sensor element are configured to provide data corresponding to treatment of the tumor treatment site. The sensor body further includes a transmitter coil and associated electronic components configured for wireless transmittal of the data to a spatially remote receiver. In addition, the sensor body includes a high-atomic weight member that is configured to be detectable by an imaging modality. The sensor unit is configured to be inductively powered to wirelessly transmit the data to the remote receiver while remaining implanted proximate the tumor treatment site. Related medical systems and methods of operation are also discussed.

Claims

1. An implantable biocompatible sensor unit, comprising:

a sensor body comprising a biocompatible material and having at least one sensor element configured for in vivo placement proximate a tumor treatment site and configured to provide data corresponding to treatment thereof;

a transmitter coil and associated electronic components within the sensor body configured for wireless transmittal of the data to a spatially remote receiver; and

a high-atomic weight member within the sensor body configured to be detectable by an imaging modality,

wherein the sensor unit is configured to be inductively powered to wirelessly transmit the data to the remote receiver while remaining implanted proximate the tumor treatment site.

2. An implantable biocompatible sensor unit according to claim 1, further comprising:

a second high-atomic weight member within the sensor body configured to be detectable by the imaging modality and axially spaced apart from the first high-atomic weight member.

3. An implantable biocompatible sensor unit according to claim 2, wherein the at least one sensor element comprises first and second axially spaced apart sensor elements configured to respectively provide radiation data to the remote receiver to define a radiation dose gradient measurement proximate the tumor treatment site based on the radiation data and an orientation of the sensor body determined from detection of the first and second high-atomic weight members.

4. An implantable biocompatible sensor unit according to claim 1, wherein at least a portion of the transmitter coil comprises the high-atomic weight member.

5. An implantable biocompatible sensor unit according to claim 1, wherein the high-atomic weight member comprises a clip snugly residing against a substantially cylindrical antenna core extending within at least a portion of the sensor body and at least partially through the transmitter coil.

6. An implantable biocompatible sensor unit according to claim 5, wherein the sensor body comprises a substantially cylindrically shaped body having opposing first and second ends, and wherein the clip is substantially cylindrical and resides within the first end of the sensor body.

7. An implantable biocompatible sensor unit according to claim 6, wherein the clip further comprises an axially extending gap configured to separate long edges of the clip.

8. An implantable biocompatible sensor unit according to claim 5, wherein the transmitter coil comprises insulated gold wire.

9. An implantable biocompatible sensor unit according to claim 8, wherein the transmitter coil is located at a first end of the sensor body, and wherein the clip is located at a second end of the sensor body axially spaced apart from the first end.

10. An implantable biocompatible sensor unit according to claim 1, wherein the high-atomic weight member comprises at least one of gold and/or platinum.

11. An implantable biocompatible sensor unit according to claim 1, wherein the sensor element is configured to detect beta, photon, and/or gamma radiation.

12. An implantable biocompatible sensor unit according to claim 1, wherein the sensor body is configured to periodically output the data over time to provide substantially real-time data of the internal condition of a tumor or tissue proximate thereto.

13. A medical system for patients undergoing treatment for cancer, the system comprising:

at least one wireless implanted sensor unit configured for in vivo placement proximate a tumor treatment site, the at least one sensor unit being configured to provide data including at least one sensed internal parameter, the at least one sensor unit including a high-atomic weight member held in a biocompatible housing and configured to be visualized as a fiducial marker by an imaging modality, wherein the at least one sensor unit is configured to be inductively powered to wirelessly transmit the data; and

an external reader configured to inductively power the at least one sensor unit and configured to receive the data from the at least one sensor unit,

wherein the system is configured to dynamically monitor selected in vivo parameters associated with one or more of dose and/or processing of a therapy administered to the tumor treatment site based on the data from the at least one sensor unit.

14. A system according to claim 13, wherein the high-atomic weight member is detectable in images generated using computed tomography (CT), megavolt (MV) radiation therapy, and/or other imaging modalities.

15. A system according to claim 13, wherein the at least one wireless implanted sensor unit further comprises a second high-atomic weight member held in the biocompatible housing axially spaced apart from the first high-atomic weight member and configured to be detected by the imaging modality.

16. A system according to claim 15, wherein the system is configured to define an orientation of the sensor body using spatial data derived from detection of the first and second high-atomic weight members by the imaging modality.

17. A system according to claim 16, wherein the at least one sensor unit comprises first and second axially spaced apart sensor elements configured to respectively provide radiation data to the external reader to define a radiation dose gradient measurement based on the orientation of the sensor unit.

18. A system according to claim 13, wherein the high-atomic weight member comprises a clip snugly residing against a substantially cylindrical antenna core extending within at least a portion of the sensor unit.

19. A system according to claim 13, wherein the system is configured to dynamically adjust administration of the therapy to thereby improve localized delivery of radiation dose responsive to detection of the high-atomic weight member in the sensor unit.

20. A method for treating a patient for cancer, the method comprising:

positioning at least one wireless sensor unit including at least one sensor element and a high-atomic weight member therein in the body of the patient proximate a tumor treatment site;

determining a position of the sensor unit proximate to the tumor treatment site using an imaging modality based on the high-atomic weight member;

administering a radiation therapy to the patient based on the determined position;

detecting in vivo a signal from the at least one sensor unit corresponding to the dose of the administered therapy proximate the tumor treatment site;

relaying the signal to a location external of the patient'"'"'s body; and

dynamically adjusting administration of the therapy to thereby improve the localized delivery of radiation dose based on changes in the determined position.

21. A method according to claim 20, wherein the sensor unit includes a second high-atomic weight member therein axially spaced apart from the first high-atomic weight member, wherein the at least one sensor element comprises first and second axially spaced apart sensor elements, and further comprising:

determining an orientation of the sensor body using spatial data derived from the determined position of the first and second high-atomic weight members by the imaging modality; and

defining a radiation dose gradient measurement based on the signal from the sensor unit and the determined orientation of the sensor body.