DEVICE AND METHODS FOR CALIBRATING ANALYTE SENSORS
First Claim
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1. A method of calibrating an analyte sensor, the method comprising:
- providing a vessel containing a first solution, wherein a sensing region of the sensor is in contact with said first solution;
obtaining a first calibration signal from the sensor;
adding an amount of a second solution into said vessel by means of a syringe, whereupon said sensor produces another calibration signal; and
calculating a calibration factor using said first calibration signal and any additional calibration signals, thereby calibrating the analyte sensor.
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Abstract
The present invention relates to methods and systems for multipoint calibration of an analyte sensor. More specifically, the methods can be used to calibrate glucose sensors.
612 Citations
48 Claims
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1. A method of calibrating an analyte sensor, the method comprising:
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providing a vessel containing a first solution, wherein a sensing region of the sensor is in contact with said first solution; obtaining a first calibration signal from the sensor; adding an amount of a second solution into said vessel by means of a syringe, whereupon said sensor produces another calibration signal; and calculating a calibration factor using said first calibration signal and any additional calibration signals, thereby calibrating the analyte sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A kit for multipoint calibration of an analyte sensor comprising:
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a vessel containing a calibration solution, wherein said vessel has a port; and a syringe for delivery of an analyte. - View Dependent Claims (14)
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15. A method of calibrating an analyte sensor, the method comprising:
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providing a vessel comprising at least two linearly adjacent chambers, wherein each chamber contains a solution, and wherein each chamber is separated from the chamber adjacent to it by a divider such that the solution in each chamber is substantially prevented from mixing with the solution in any other chamber;
wherein a sensing region of the sensor is in contact with the solution in one of the chambers;obtaining a first calibration signal from the sensor; moving the sensing region of the sensor into an adjacent chamber, thereby contacting the sensing region with the solution in said adjacent chamber, whereupon the sensor produces an additional calibration signal; and calculating a calibration factor using said first calibration signal and any additional calibration signals, thereby calibrating the analyte sensor. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23)
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24. A method of calibrating an analyte sensor, the method comprising:
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exposing the sensing region of the sensor to a solution, whereupon the sensor produces a first calibration signal; combining at least one timed-release capsule with said solution, wherein said timed-release capsule contains an analyte; allowing each timed-release capsule to release said analyte contained within it, whereupon the sensor produces another calibration signal; and calculating a calibration factor using said first calibration signal and any additional calibration signals, thereby calibrating said analyte sensor. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33)
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34. A method of calibrating an analyte sensor, the method comprising:
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obtaining a vessel containing a solution, wherein a sensing region of the sensor is in contact with said solution; and
wherein said vessel comprises at least one rupturable chamber containing an analyte, wherein said analyte is initially substantially separated from said solution;obtaining a first calibration signal from the sensor; rupturing each rupturable chamber, thereby releasing the analyte within it, whereupon the sensor produces another calibration signal; and calculating a calibration factor using said first calibration signal and any additional calibration signals, thereby calibrating said analyte sensor. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42)
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43. A ready-to-calibrate and deploy, sterilized analyte sensor kit, comprising:
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an analyte sensor comprising an elongate body having an indicator system disposed along a distal portion of the elongate body; and a calibration vessel comprising a sensor port through which the distal portion of the sensor is sealably retained within the vessel until retracted for use, and the vessel further comprising a calibration means in fluid communication with the vessel, wherein the sensor and vessel are pre-assembled, sterilized and sealed within a sterile package, ready for calibration and deployment. - View Dependent Claims (44)
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45. A ready-to-calibrate and deploy, sterilized analyte sensor kit, comprising:
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an analyte sensor comprising an elongate body having an indicator system disposed along a distal portion of the elongate body and an coupling member configured to interface with an analyte monitor comprising a calibration algorithm; a calibration apparatus comprising a calibration chamber sized to slidably receive and accommodate therein the distal portion of the elongate body of the sensor, an adjustable sealing means for sealing the distal portion within the calibration chamber, an infusion port fluidly coupled to the calibration chamber, and a fluid waste receptacle fluidly coupled to the calibration chamber; and wherein the analyte sensor is slidably engaged within the calibration apparatus, sterilized and sealed within a sterile package, ready for calibration and deployment. - View Dependent Claims (46, 47, 48)
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Specification