Temperature-Adjusted Analyte Determination For Biosensor System
First Claim
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1. A method for determining an analyte concentration in a sample of a biological fluid, comprising:
- determining a sample temperature;
generating an output signal in response to a redox reaction of an analyte in the sample;
adjusting a correlation between analyte concentrations and output signals at a reference temperature in response to temperature; and
determining the analyte concentration from the temperature-adjusted correlation and the output signals at the sample temperature.
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Abstract
A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature.
40 Citations
32 Claims
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1. A method for determining an analyte concentration in a sample of a biological fluid, comprising:
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determining a sample temperature; generating an output signal in response to a redox reaction of an analyte in the sample; adjusting a correlation between analyte concentrations and output signals at a reference temperature in response to temperature; and determining the analyte concentration from the temperature-adjusted correlation and the output signals at the sample temperature. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 22, 23)
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13. A method for adjusting a correlation between analyte concentrations and output signals at a reference temperature in response to temperature, comprising:
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determining the correlations between analyte concentrations and output signals for a reference temperature and at least one other temperature; developing normalized temperature functions of slope and intercept for the correlation of the reference temperature; and adjusting the correlation of the reference temperature in response to the normalized temperature functions of slope and intercept. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21)
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24. A biosensor for determining an analyte concentration in a biological fluid, comprising:
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a measuring device having a processor connected to a sensor interface and a temperature sensor; a sensor strip having a sample interface on a base, where the sample interface is adjacent to a reservoir formed by the base; and where the processor adjusts a correlation between analyte concentrations and output signals at a reference temperature in response to a sample temperature from the temperature sensor, and where the processor determines an analyte concentration from the temperature-adjusted correlation in response to an output signal from the sample interface. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32)
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Specification