Methods for Treating Body Tissue

• US 20090023648A1
• Filed: 10/23/2007
• Published: 01/22/2009
• Est. Priority Date: 05/05/1995
• Status: Abandoned Application

• Current Assignee: Spine Wave Incorporated
• Original Assignee: Protein Polymer Technologies, Inc.
• Inventors: Stredonsky, Edwin R., Cappello, Joseph
• Application Number:
  US11/877,557
• Publication Number:
  US 20090023648A1
• Time in Patent Office: Days
• US Class Current: 514/1.100
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61L 24/106 Fibrin; Fibrinogen
• CPC Class Codes: A61L 24/108 Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07K 14/001 by chemical synthesis
• CPC Class Codes: Y10S 530/81 Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier

Abstract

Methods of treating body tissue including repairing defects in body tissue as well as augmenting body tissue. Body tissue defects are repaired by injecting a polymeric adhesive composition through an injector into the region of the defect and allowing the adhesive composition to cure to repair the defect or to form an implant that adheres to at least one surface tissue in the region of the defect. Body tissue is augmented by filling a defect void with a polymeric adhesive composition and allowing it to cure.

Claims

1. A method of repairing a defect in a body tissue, the method comprising:

positioning an injector proximate to a defect in a body tissue;

injecting a curable polymeric adhesive composition through the injector into a region of the defect; and

allowing the adhesive composition to cure at the site of the defect, thereby repairing at least a portion of the defect.

2. The method of claim 1, wherein the curable polymeric adhesive composition repairs at least a portion of the defect by adhering to tissue during curing.

3. The method of claim 1, wherein the curable polymeric adhesive composition comprises a curable polymer and a chemical crosslinker.

4. The method of claim 3, wherein the chemical crosslinker is pre-mixed with the curable polymer before the injecting step.

5. The method of claim 1, further comprising injecting a chemical crosslinker into a region of the defect.

6. The method of claim 3, wherein the chemical crosslinker is selected from the group consisting of dialdehydes, diisocyanates, acid anhydrides, diamines and combinations thereof.

7. The method of claim 3, wherein the chemical crosslinker is hexamethylene diisocyanate (HMDI).

8. The method of claim 1, wherein the curable polymeric adhesive composition comprises a curable protein copolymer solution.

9. The method of claim 1, wherein the curable polymeric adhesive composition comprises repeating blocks of amino acid sequence.

10. The method of claim 1, wherein the curable polymeric adhesive composition comprises a network of polymer chains including repeating elastin-like and fibroin-like sequences.

11. The method of claim 10, wherein the repeating fibroin-like sequences of the polymer chains of the curable polymeric adhesive composition comprise the sequence:

GAGAGS (SEQ ID NO;

1).

12. The method of claim 10, wherein the repeating elastin-like sequences of the polymer chains of the curable polymeric adhesive composition comprise the sequence:

GVGVP (SEQ ID NO;

2).

13. The method of claim 10, wherein the repeating elastin-like sequences of the polymer chains of the curable polymeric adhesive composition comprise the sequence:

GKGVP (SEQ ID NO;

3), wherein the K serves as a crosslinking site.

14. The method of claim 10, wherein the curable polymeric adhesive composition is cured by chemically crosslinking the elastin-like sequences.

15. The method of claim 1, wherein the polymeric adhesive composition has a lap shear tensile strength of at least about 250 g/cm² when cured.

16. The method of claim 15, wherein the polymeric adhesive composition has said lap shear tensile strength of at least about 300 g/cm² within a cure time of about 5 to about 30 minutes.

17. The method of claim 1, wherein the polymeric adhesive composition has a lap shear tensile strength of about 100 g/cm² to about 4000 g/cm² when cured.

18. The method of claim 1, wherein the defect is a hole or void in the body tissue.

19. The method of claim 1, wherein the curable polymeric adhesive composition further comprises a drug.

20. The method of claim 1, wherein the adhesive composition is bioresorbable.

21. The method of claim 1, wherein the injector is selected from the group consisting of syringe, catheter and cannula.

22. The method of claim 1, wherein said injection is done to augment tissue mass.