MULTI-RESERVOIR MEDICAL DEVICE HAVING PROTECTED INTERIOR WALLS

• US 20090024113A1
• Filed: 08/18/2008
• Published: 01/22/2009
• Est. Priority Date: 11/15/2004
• Status: Abandoned Application

• Current Assignee: MicroCHIPS Inc.
• Original Assignee: MicroCHIPS Inc.
• Inventors: Maloney, John M., Uhland, Scott A., Santini, John T. JR., Sheppard, Norman F. JR., Sbiaa, Zouhair
• Application Number:
  US12/193,523
• Publication Number:
  US 20090024113A1
• Time in Patent Office: Days
• US Class Current: 604/890.100
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: B01L 2200/12 Specific details about manufacturing devices
• CPC Class Codes: B01L 2300/0819 Microarrays; Biochips
• CPC Class Codes: B01L 2400/0677 phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
• CPC Class Codes: B01L 3/50853 with covers or lids

Abstract

An implantable medical device is provided for controlled delivery or exposure of reservoir contents. The device may include a substrate; a plurality of discrete reservoirs in the substrate, wherein the reservoirs have interior walls and at least one opening in the substrate; reservoir contents disposed in the reservoirs; a reservoir cap closing the at least one opening of each of the reservoirs to seal the reservoir contents in each of the reservoirs; and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo, wherein the interior walls of the reservoirs comprise a material to protect the substrate in vivo. For example, to enhance the resistance of the substrate to etching in vivo, the interior sidewalls of the reservoirs may include a protective coating (such as gold, platinum, carbon, silicon carbide, silicon dioxide, or platinum silicide), or the sidewalls may include a doped silicon.

Claims

1. An implantable medical device for the controlled delivery or exposure of reservoir contents comprising:

a substrate;

a plurality of discrete reservoirs in the substrate, wherein the reservoirs have interior walls and at least one opening in the substrate;

reservoir contents disposed in the reservoirs;

a reservoir cap closing the at least one opening of each of the reservoirs to seal the reservoir contents in each of the reservoirs; and

control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo,

wherein the interior walls of the reservoirs comprise a material to protect the substrate in vivo.

2. The device of claim 1, wherein the interior walls have at least one protective layer of the material coated thereon.

3. The device of claim 2, wherein the protective layer comprises gold, platinum, diamond-like carbon, silicon carbide, silicon dioxide, or platinum silicide.

4. The device of claim 1, wherein the interior walls comprise silicon doped with a dopant to enhance the resistance of the silicon to etching in vivo.

5. The device of claim 4, wherein the silicon is doped with boron.

6. The device of claim 1, wherein the substrate comprises a silicon wafer.

7. The device of claim 1, wherein the substrate comprises a polymer.

8. The device of claim 1, wherein the reservoirs are micro-reservoirs.

9. The device of claim 1, wherein the reservoir contents comprise a drug.

10. The device of claim 1, wherein the reservoir contents comprise a sensor or sensor component.