Perfusion Assessment Based on Animated Perfusion Imaging

• US 20090028406A1
• Filed: 04/13/2006
• Published: 01/29/2009
• Est. Priority Date: 04/14/2005
• Status: Active Grant

• Current Assignee: Bracco Suisse SA
• Original Assignee: Bracco International B.V. (Bracco SPA)
• Inventors: Rognin, Nicolas, Frinking, Peter, Arditi, Marcel
• Granted Patent: US 8,036,437 B2
• Time in Patent Office: Days
• US Class Current: 382/131
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/13 Tomography A61B8/10, A61B8/12 take precedence; tomography for radiation diagnosis A61B6/02
• CPC Class Codes: A61B 8/463 characterised by displaying multiple images or images and diagnostic data on one display composite display in devices for short-range imaging with acoustic waves G01S7/52074
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61B 8/5238 for combining image data of patient, e.g. merging several images from different acquisition modes into one image for image registration algorithms G06T7/30
• CPC Class Codes: G01S 15/8977 using special techniques for image reconstruction, e.g. FFT, geometrical transformations, spatial deconvolution, time deconvolution
• CPC Class Codes: G06T 2207/30004 Biomedical image processing
• CPC Class Codes: G06T 7/20 Analysis of motion motion estimation for coding, decoding, compressing or decompressing digital video signals H04N19/43, H04N19/51

Abstract

An embodiment of a medical imaging system is proposed. The system includes means for providing a sequence of recorded input images each one offering a digital representation at a corresponding instant of a body part being perfused with a contrast agent, each input image including a plurality of visualizing values each one representing a corresponding portion of the body part, and means for associating each sequence of corresponding sets in the input images of at least one visualizing value with a model function of time; the system further includes means for generating a sequence of computed images at further instants, each computed image including a plurality of further visualizing values each one being determined by an instantaneous function-value which is calculated from the associated model function at the corresponding further instant, and means for displaying the sequence of computed images.

Claims

1. A medical imaging system including:

means for providing a sequence of recorded input images each one offering a digital representation at a corresponding instant of a body part being perfused with a contrast agent, each input image including a plurality of visualizing values each one representing a corresponding portion of the body part,

means for associating each sequence of corresponding sets in the input images of at least one visualizing value with a model function of time,

means for generating a sequence of computed images at further instants, each computed image including a plurality of further visualizing values each one being determined by an instantaneous function-value which is calculated from the associated model function at the corresponding further instant, and

means for displaying the sequence of computed images.

2. The system according to claim 1, wherein the means for generating the sequence of computed images includes means for selecting a reference region in the input images, means for generating a sequence of reference values at the further instants each one based on other instantaneous function-values being calculated from the model functions associated with the visualizing values of the reference region at the corresponding further instant, and means for setting each further visualizing value according to a combination of the instantaneous function-value and the reference value at the corresponding further instant.

3. The system according to claim 2, wherein the means for generating the sequence of reference values includes means for setting each reference value according to an average of the other instantaneous function-values at the corresponding further instant.

4. The system according to claim 2, wherein the means for setting each further visualizing value includes means for subtracting the reference value from the instantaneous function-value at the corresponding further instant.

5. The system according to claim 24, wherein each instantaneous function-value and/or each other instantaneous function-value corresponds to the value of the associated model function at the corresponding further instant.

6. The system according to claim 2, wherein each instantaneous function-value and/or each other instantaneous function-value corresponds to the integral of the associated model function at the corresponding further instant.

7. The system according to claim 1, wherein the means for determining the sequence of computed images includes means for setting each further visualizing value to the instantaneous function-value, the instantaneous function-value corresponding to the value of the associated model function at the corresponding further instant.

8. The system according to claim 1, wherein the means for generating the sequence of computed images includes means for setting each further visualizing value to the instantaneous function-value, the instantaneous function-value corresponding to the integral of the associated model function at the corresponding further instant.

9. The system according to claim 1, wherein each set of at least one visualizing value consists of a single pixel value, a single voxel value, a plurality of pixel values, or a plurality of voxel values.

10. The system according to claim 1, wherein the means for associating includes means for linearizing each input image to make each visualizing value thereof substantially proportional to a concentration of the contrast agent in the corresponding portion of the body part.

11. The system according to claim 1, further including:

means for generating a sequence of overlaid images by overlaying the sequence of computed images on the sequence of input images, and

means for displaying the sequence of overlaid images.

12. The system according to claim 11, wherein the means for generating the sequence of overlaid images includes means for resetting each further visualizing value not reaching a threshold value.

13. The system according to claim 11, wherein the means for generating the sequence of overlaid images includes:

means for estimating an indicator of a quality of each association, and

means for resetting each further visualizing value having the corresponding indicator not reaching a further threshold value.

14. The system according to claim 1, wherein the means for generating the sequence of computed images further includes means for removing an offset from the associated model function.

15. The system according to claim 1, wherein the means for generating the sequence of computed images further includes means for associating a plurality of predefined colors with corresponding ranges of values of the further visualizing values and means for replacing each further visualizing value with a representation of the corresponding color.

16. The system according to claim 1, wherein the means for providing the sequence of input images includes means for discarding at least one of the input images.

17. The system according to claim 11, wherein a rate of the sequence of input images is lower than a rate of the sequence of computed images.

18. The system according to claim 17, wherein the means for generating the sequence of overlaid images includes means for inserting at least one further input image into the sequence of input images to equalize the rate of the sequence of input images with the rate of the sequence of computed images, each computed image being overlaid on a corresponding input image.

19. The system according to claim 1, wherein the means for providing the sequence of input images includes means for acquiring the input images in succession from the body part.

20. The system according to claim 19, wherein the means for acquiring the input images includes means for transmitting ultrasound waves and for recording corresponding echo signals.

21. A medical imaging method including the steps of:

providing a sequence of recorded input images each one offering a digital representation at a corresponding instant of a body part being perfused with a contrast agent, each input image including a plurality of visualizing values each one representing a corresponding portion of the body part,

associating each sequence of corresponding sets in the input images of at least one visualizing value with a model function of time,

generating a sequence of computed images at further instants, each computed image including a plurality of further visualizing values each one being determined by an instantaneous function-value which is calculated from the associated model function at the corresponding further instant, and

displaying the sequence of computed images.

22. A computer program for performing the method of claim 21 when the computer program is executed on a data processing system.

23. A computer program product including a computer-usable medium embodying a computer program, the computer program when executed on a data processing system causing the system to perform a medical imaging method, wherein the method includes the steps of:

providing a sequence of recorded input images each one offering a digital representation at a corresponding instant of a body part being perfused with a contrast agent, each input image including a plurality of visualizing values each one representing a corresponding portion of the body part,

associating each sequence of corresponding sets in the input images of at least one visualizing value with a model function of time,

generating a sequence of computed images at further instants, each computed image including a plurality of further visualizing values each one being determined by an instantaneous function-value which is calculated from the associated model function at the corresponding further instant, and

displaying the sequence of computed images.