SENSING DEVICE, APPARATUS AND SYSTEM, AND METHOD FOR OPERATING THE SAME

• US 20090030293A1
• Filed: 02/10/2006
• Published: 01/29/2009
• Est. Priority Date: 02/11/2005
• Status: Abandoned Application

• Current Assignee: University Court of the University of Glasgow (University of Glasgow)
• Original Assignee: University Court of the University of Glasgow (University of Glasgow)
• Inventors: Cumming, David Robert Sime, Wood, Nicholas, Wang, Lei, Cooper, Jonathan Mark
• Application Number:
  US11/815,841
• Publication Number:
  US 20090030293A1
• Time in Patent Office: Days
• US Class Current: 600/302
• CPC Class Codes: A61B 1/00016 using wireless means
• CPC Class Codes: A61B 1/00036 Means for power saving, e.g. sleeping mode
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging
• CPC Class Codes: A61B 2560/0209 adapted for power saving
• CPC Class Codes: A61B 2560/0271 using a remote monitoring unit
• CPC Class Codes: A61B 5/0028 Body tissue as transmission medium, i.e. transmission systems where the medium is the human body
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/447 specially adapted for aiding the prevention of ulcer or pressure sore development, i.e. before the ulcer or sore has developed

Abstract

A sensing device, apparatus and system, and method for operating the same are provided. The sensing apparatus includes a first module and a second module. The first module includes a controller, a transmitter and an array of sensor elements. The controller is capable of activating one or more sensor elements in the array independently of others in the array, in order to obtain a sensor output from the array at different times by using different sensor elements in said array. The transmitter is configured to transmit sensor data derived from the sensor output from the first module to a receiver of the second module. Each sensor element is a biological sensor for detecting the presence of the same analyte in the environment in which the sensor array is to be deployed.

Claims

1. A sensing apparatus including a first module and a second module, said first module having a controller, a transmitter and an array of sensor elements, said controller being capable of activating one or more sensor elements in said array independently of others in the array, in order to obtain a sensor output from said array at different times by using different sensor elements in said array, said transmitter being configured to transmit sensor data, derived from said sensor output, from said first module to a receiver of said second module, wherein each sensor element is a biological sensor for detecting the presence of the same analyte in the environment in which the sensor array is to be deployed.

2. A sensing apparatus according to claim 1 wherein the first module is adapted:

(i) to be swallowable, for passage through the human or animal body;

(ii) to be implantable in the human or animal body;

or

(iii) to be placed at a surface location of the human or animal body (e.g. wound site)

3. A sensing apparatus according to claim 1 or claim 2 wherein each sensor element is activatable only once to attempt to detect the presence of said analyte in said environment.

4. A sensing apparatus according to any one of claims 1 to 3 wherein said sensor output corresponds to an analyte condition of at least one of:

analyte present;

analyte not present;

a quantitative measure of the concentration of analyte detected.

5. A sensing apparatus according to any one of claims 1 to 4 wherein said analyte is blood, or haemoglobin, or another component of blood or a degradation product of blood.

6. A sensing apparatus according to any one of claims 1 to 5 wherein activation of a sensor element in said array allows analyte present in the environment of the sensor element to catalyse a chemical reaction between a first reagent and a second reagent, detection of said chemical reaction by said sensor element determining the sensor element output.

7. A sensing apparatus according to claim 6 wherein each sensor element includes a reagent space containing at least said first reagent.

8. A sensing apparatus according to claim 7 wherein said reagent space also contains said second reagent.

9. A sensing apparatus according to claim 8 wherein said second reagent is in contact with said first reagent.

10. A sensing apparatus according to any one of claims 7 to 9, said reagent space being separated from an electrolyte space by a semi-permeable membrane, said electrolyte space having a working electrode, a counter electrode and optionally a reference electrode, said electrodes being in electrical contact with electrolyte in said electrolyte space.

11. A sensing apparatus according to any one of claims 7 to 10, said reagent space being exposable to said environment on activation of said sensor element.

12. A sensing apparatus according to claim 11, each sensor element including a cover member for covering said reagent space, said cover member being at least partially removable to allow exposure of said reagent space.

13. A sensing apparatus according to claim 12 wherein said cover member is at least partially removable by application of an electrical voltage to said cover member.

14. A sensing apparatus according to claim 13 wherein said electrical voltage triggers at least one of corrosion, dissolution, melting, sublimation and breakage of said cover member.

15. A sensing apparatus according to any one of claims 6 to 14 wherein said first reagent comprises alpha guaiaconic acid or derivative thereof.

16. A sensing apparatus according to any one of claims 6 to 15 wherein the second reagent is a mediator capable of oxidising the first reagent in the presence of a catalyst.

17. A sensing apparatus according to any one of claims 1 to 16 wherein said sensor array is provided at an outer surface of said first module, so as to be provided in contact with the environment in which the first module is to be deployed.

18. A sensing apparatus according to any one of claims 1 to 17 wherein said array includes at least four sensor elements.

19. A sensing apparatus according to any one of claims 1 to 18, wherein said array includes at least nine sensor elements.

20. A sensing apparatus according to any one of claims 1 to 19 wherein said controller is operable to activate said sensor elements at predetermined time intervals.

21. A sensing apparatus according to any one of claims 1 to 20 wherein the sensor array of the first module forms a first sensor and the first module further includes a second sensor, said second sensor being operable to measure a parameter of the environment in which the first module is to be deployed.

22. A sensing apparatus according to claim 21 wherein the output of the second sensor is used by the controller to determine the time at which a sensor element of the sensor array is activated.

23. A sensing apparatus according to claim 21 or claim 22 wherein the first module further includes a third sensor, said third sensor being operable to measure a parameter of the environment in which the first module is to be deployed, different to the parameter measured by the second sensor.

24. A sensing apparatus according to claim 23 wherein the output of both the second and third sensors is used by the controller to determine the time at which a sensor element of the sensor array is activated.

25. A sensing apparatus according to claim 23 or 24 wherein the second and third sensors are selected from:

a pH sensor, a temperature sensor, a dissolved oxygen sensor, a conductivity sensor, a biochemical sensor, an optical sensor and an acoustic sensor.

26. A method of operating a sensing apparatus including a first module and a second module, said first module having a controller, a transmitter and an array of sensor elements, the method including the steps of:

(i) said controller activating at least one sensor element in said array independently of others in the array, so as to obtain a sensor output from said at least one sensor element at a first time t1;

(ii) said controller activating at least one further sensor element in said array independently of others in the array, so as to obtain a sensor output from said at least one further sensor element at time t2, different to t1; and

(iii) transmitting sensor data from said first module to a receiver of said second module,

wherein each sensor element is a biological sensor for detecting the presence of the same analyte in the environment in which the sensor array is to be deployed.

27. A method according to claim 26, further including the step of the controller activating said sensor elements sequentially at different times t so as to obtain a sequence of sensor outputs from said array, corresponding to the detection or absence of said analyte in said environment at said different times t.

28. A method according to claim 26 or claim 27 wherein each sensor element is activated a maximum of one time only, to attempt to detect the presence of said analyte.

29. A sensing device designed for passage through the digestive system of a human or animal body, or implantation into a human or animal body, the device having a first sensor for measuring a first parameter, electronic circuitry or software for calibrating the first sensor in accordance with a calibration routine and a transmitter for transmitting data derived from the first sensor'"'"'s output to an external device, wherein said circuitry is configured to calibrate the sensor by varying the gain of a variable gain amplifier connected to the sensor and/or by varying an offset voltage applied to the sensor or by varying an offset voltage applied to an amplifier connected to the sensor.

30. A sensing device according to claim 29 wherein the device is a swallowable capsule.

31. A sensing device according to claim 29 or claim 30 wherein the calibration routine is a routine for optimising the dynamic range of the sensor.

32. A sensing device according to any one of claims 29 to 31 wherein the calibration routine comprises the step of determining a relationship between the sensor output and the actual physical value of the measured parameter.

33. A sensing device according to any one of claims 29 to 32 wherein the calibration routine is a routine in which the sensor or surrounding circuitry is adjusted until the sensor has zero output.

34. A sensing device according to any one of claims 29 to 32 wherein said calibration routine is a routine for compensating for drift of said first sensor output over time, the compensation being carried out in accordance with a model of sensor drift over time.

35. A sensing device according to claim 34 wherein the model of sensor drift over time is a predetermined model stored in a memory.

36. A sensing device according to claim 34 wherein the model of sensor drift is calculated while the sensor is in use, by extrapolating previous data points measured by the sensor.

37. A sensing device according to any one of claims 34 to 36 wherein the sensor output is adjusted at regular intervals according to said model in order to compensate for sensor drift.

38. A sensing device according to any one of claims 29 to 32 wherein the calibration routine is a routine in which the sensor output is adjusted such that it indicates the value of the sensed parameter relative to specified reference value.

39. A sensing device according to any one of claims 29 to 32 wherein the calibration routine is a routine in which the sensor is exposed to a known stimulus and the sensor output is adjusted until it is equal to a predetermined value or within a predetermined range specified for said known stimulus.

40. A sensing device according to claim 39 wherein the sensing device is provided in casing containing a liquid or gel having a known value for the physical parameter which the first sensor is designed to measure, and wherein said calibration routine is configured to calibrate the sensor with reference to the sensor'"'"'s output in response to measuring said liquid or gel.

41. A sensing device according to any one of claims 29 to 40 wherein the sensing device is configured to transmit calibration data to an external device.

42. A sensing device according to any one of claims 29 to 41 wherein the sensing device is configured to carry out said calibration autonomously without reference to instructions or data from an external electronic device.

43. A sensing device according to any one of claims 29 to 41 wherein said sensing device has a receiver for receiving control instructions and/or calibration data from an external device and is configured to carry out said calibration with reference to said control instructions and/or calibration data received from an external device.

44. A sensing device according to any one of claims 29 to 43 wherein the first sensor is a pH sensor, a temperature sensor, a blood sensor, a dissolved oxygen sensor, a conductivity sensor, a biochemical sensor, an optical sensor or an acoustic sensor.

45. A sensing device according to any one of claims 29 to 44 wherein the first sensor comprises an ISFET.

46. A sensing device according to any one of claims 29 to 45 wherein the sensing device'"'"'s transmitter is a radio transmitter, an induced magnetic field transmitter or an acoustic transmitter.

47. A sensing device according to any one of claims 29 to 46, further comprising a second sensor for measuring a second parameter different to said first parameter, and wherein the calibration routine is configured to adjust the output of said first sensor on the basis of a reading from said second sensor.

48. A sensing device according to claim 47, further comprising a controller for switching on the first sensor when the output from the second sensor displays a predetermined characteristic, or switching on the first sensor a set period of time after the output from the second sensor displays said predetermined characteristic.

49. A sensing device according to claim 47 or claim 48 wherein said first sensor is a blood sensor and said second sensor is a pH sensor.

50. A sensing device according to claim 48 wherein the controller is configured to switch on said first sensor autonomously without input from an external device.

51. A sensing device according to any one of claims 29 to 50, further comprising a processor configured to detect a characteristic event in the first sensor output indicating that the sensing device is at a particular location in the body and to store in a memory and/or transmit to an external device, location data indicating the location of the sensing device.

52. A sensing device according to claim 51 wherein the first sensor is a pH sensor.

53. A sensing device according to claim 51 or claim 52 wherein the processor is configured to detect that the sensing device has left the small bowel and entered the large bowel when the output from the first sensor indicates that the pH has switched from an acidic pH to an alkaline pH.

54. A system for measuring a parameter comprising a first module in the form of a sensing device according to any one of claims 29 to 53 and a second module comprising a receiver for receiving data transmitted by said first module'"'"'s transmitter.

55. A system according to claim 54 wherein said first module further comprises a receiver for receiving instructions and/or data from said second module;

said second module further comprises a transmitter for sending instructions and/or data to said second module and a processor and wherein said processor of the second module is configured to send calibration instructions and/or calibration data to said first module and said first module is configured to calibrate the first sensor on the basis of said received instructions and/or data.

59. A system according to claim 56 having a sensing device according to claim 48 wherein the controller is configured to carry out said adjustment of the output of the first sensor, on the basis of the second sensor reading, in response to instructions sent by the second module.

56. A system for measuring a parameter comprising a first module in the form of a sensing device for use in a human or animal body having a first sensor for measuring a first parameter and a transmitter for transmitting measurements made by said first sensor and calibration data generated by said first module to a second module;

the second module comprising a receiver for receiving data output by said first module'"'"'s transmitter, and a processor for processing said data, wherein said second module'"'"'s processor is configured to calibrate the measurements made by the first sensor in accordance with a calibration routine and on the basis of calibration data sent by said first module.

57. A system according to claim 56 wherein said calibration routine is a routine for compensating for drift of said first sensor output over time, the compensation being carried out in accordance with a model of sensor drift over time.

58. A system according to claim 56 wherein the calibration routine is a routine for relating the first sensor output to an actual physical value of the measured parameter.

60. Apparatus for gathering data comprising:

a first module suitable for placement inside or passage through a human or animal body, the first module comprising a first clock, at least one sensor, a power supply for supplying power to said first clock and said at least one sensor and a transmitter for transmitting sensor data from said at least one sensor; and

a second module comprising a second clock, a receiver and a processor configured to receive data sent from said first module'"'"'s transmitter, estimate the first clock'"'"'s clock rate and compensate the received sensor data for variations in the power of said first module'"'"'s power source by adjusting the sensor data on the basis of said estimated first clock rate.

61. Apparatus according to claim 60 wherein the first module'"'"'s transmitter is a radio transmitter and the second module'"'"'s receiver is a radio receiver.

62. Apparatus according to claim 60 or claim 61 wherein the first module is a swallowable capsule or an implant device for insertion into the large bowel having an aperture for allowing passage of body fluids.

63. Apparatus according to any one of claims 60 to 62 wherein the first module'"'"'s at least one sensor outputs a series of sensor values each corresponding to a sensor reading taken at a respective time, and wherein for each respective sensor value, the second module'"'"'s processor estimates the first clock'"'"'s clock rate at the time when said sensor value was taken and adjusts each respective sensor value to compensate for variations in power from said first module'"'"'s power supply.

64. Apparatus according to any one of claims 60 to 63 wherein the clock rate of the first clock is estimated on the basis of the rate at which data from the first module is received by the second module.

65. Apparatus according to any one of claims 60 to 64 wherein the compensation is carried out on the basis of a predetermined relationship between the sensor and the voltage supplied by the power supply and a predetermined relationship between the clock rate of the first clock and the voltage supplied to the first clock by the power supply.

66. Apparatus according to any one of claims 60 to 65 wherein the sensor data is transmitted by the transmitter according to a protocol in which said data is split into one or more data packets, each data packet having a fixed predetermined length and wherein each data packet is separated from other data packets by a period of no signal transmission, having a fixed predetermined length.

67. Apparatus according to claim 66 wherein each data packet has a start sequence of one or more bits marking the start of the data packet and a stop sequence of one or more bits marking the end of the data packet.

68. Apparatus according to any one of claims 60 to 67 wherein signal transmission from said first module to said second module is asynchronous.

69. Apparatus according to any one of claims 60 to 68 wherein the at least one sensor is selected from a temperature sensor, a camera, a blood sensor, a pH sensor, a dissolved oxygen sensor, a conductivity sensor and a pressure sensor.

70. Apparatus according to any one of claims 60 to 69 wherein the first module does not have a regulator for regulating the voltage output from the first module'"'"'s power supply.

71. Apparatus according to any one of claims 60 to 70 wherein the first clock is a low Q clock having a value of Q less than 20.

72. Apparatus according to any one of claims 60 to 71 wherein the first module'"'"'s transmitter transmits according to a CDMA system and wherein there are a plurality of said first modules, each transmitting on a different channel.

73. Apparatus according to any one of claims 60 to 72 wherein the processor is configured to pre-process the analogue signal from the receiver to generate a probability histogram to determine a voltage threshold to distinguish 0s and 1s in the analogue signal.

74. Apparatus according to any one of claims 60 to 73 wherein the first module has a first sensor and a second sensor and the second module'"'"'s processor is configured to adjust the sensor values in the sensor data from the first sensor based on the sensor values in sensor data from the second sensor.

75. Apparatus according to claim 74 wherein said second sensor is a temperature sensor.

76. Apparatus according to any one of claims 60 to 75 wherein the first module does not have a receiver for receiving data from an external device.

77. Apparatus according to any one of claims 60 to 76 wherein the first module has an exterior casing with one or more grooves for channeling fluids towards one or more openings in the exterior casing.

78. Apparatus according to any one of claims 60 to 77 wherein the first module is a swallowable capsule and comprises an exterior casing having at least one helical groove, protrusion or indentation for causing the capsule to rotate as it passes through the intestinal tract.

79. A method of transmitting and receiving data in a system comprising a first module having a first clock, at least one sensor, a power supply for supplying power to said first clock and said at least one sensor and a transmitter for transmitting sensor data from said at least one sensor and a second module comprising a second clock, a receiver and a processor;

the method comprising the steps of transmitting sensor data based on the output of said at least one sensor to the second module'"'"'s receiver; and

using the second module'"'"'s processor to estimate the first clock'"'"'s clock rate and compensating the received sensor data for variations in the power of said first module'"'"'s power supply by adjusting the sensor data on the basis of said estimated first clock rate.