MICROFABRICATED CARDIAC SENSOR WITH TACTILE FEEDBACK AND METHOD AND APPARATUS FOR CALIBRATING THE SAME USING A PLURALITY OF SIGNALS

• US 20090030332A1
• Filed: 10/03/2008
• Published: 01/29/2009
• Est. Priority Date: 01/26/2005
• Status: Abandoned Application

• Current Assignee: Stuart O. Schecter
• Original Assignee: Stuart O. Schecter
• Inventors: SCHECTER, Stuart O.
• Application Number:
  US12/245,058
• Publication Number:
  US 20090030332A1
• Time in Patent Office: Days
• US Class Current: 600/508
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/02 Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/1076 for measuring dimensions inside body cavities, e.g. using catheters A61B3/1005 takes precedence
• CPC Class Codes: A61B 5/1107 Measuring contraction of parts of the body, e.g. organ, muscle apparatus for measuring work or force in general G01L
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 5/7455 characterised by tactile indication, e.g. vibration or electrical stimulation
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula

Abstract

A plurality of sensor data acquired from the heart using novel microfabricated sensors is compared to analogous data derived by conventional imaging modalities extrinsic to the heart. The cross-correlation of corresponding signals facilitates the development of sensor nanotechnologies including a catheter for performing ablation of cardiac arrhythmias and a biocompatible electrical interface with monitoring capabilities. Cross-correlation of data acquired with differing techniques enables system calibration and design, as well as, validation of the data acquired with next generation sensors. In a preferred mode of the invention, novel cardiac nanosensors enable an operator to differentiate one individual patient'"'"'s cardiac tissue mechanical properties from others by using a sense of touch much as clinicians today use auditory cues with a stethoscope.

Claims

1. A method for calibrating a catheter with a microfabricated transducer arranged and constructed to sense the physical activity of the heart comprising the steps of:

inserting said catheter about the heart;

making a set of measurements taken from said catheter through said microfabricated transducer; and

comparing said measurements with analogous data obtained from external means.

2. The method of claim 1 wherein said calibration is based on cross-correlation of data acquired by intra-cardiac and extra-cardiac measurements.

3. The method of claim 1 wherein said cardiac sensor senses the motion of the sensor responsive to the properties of the local environment.

4. The method of claim 1, wherein said calibration is based on a cross-correlation of data acquired by intra-cardiac and extra-cardiac measurements where said data is transmitted via wireless communication.

9. The method of claim 1 where said analogous extra-cardiac diagnostic modality is one or more of ultrasound, multi-dimensional cardiac navigational systems, electric and electromagnetic fields, radiographic assessment.

10. The method of claim 1, where said cardiac sensor is composed of proprioceptive whiskers provided with strain gauges for the determination of at least two orthogonal components of movement of local tissues and fluid flow.

5. A method of making a cardiac sensor comprising:

providing an elongated catheter constructed and arranged for insertion about the heart; and

attaching a cardiac motion sensor at said distal end, said cardiac sensor providing tactile feedback based on local conditions at said motion sensor.

6. The method of claim 5 further comprising calibrating said cardiac sensor based at least in part, on comparisons to analogous data acquired from extra-cardiac diagnostic modalities where said cardiac sensor data is combined with data acquired by alternate methods from a first patient.

7. The method of claim 5 where said motion sensor is a piezoelectric sensor.

8. The method of claim 5 wherein where said sensor is a piezoelectric sensor made using nanotechnology manufacturing techniques.

11. The method of claim 5 where said cardiac sensor is microfabricated using nanotechnology and composed of a biocompatible electrical interface with monitoring capabilities that is capable of one or more of pacing, defibrillation, and energy harvesting.

12. The method of claim 5 wherein the motion sensed by the cardiac sensor is communicated to the operator using tactile and/or force feedback.

13. As in claim 12 where said tactile feedback includes at least one of a representation of;

periodic vibrations, texture, sensations of enclosure, blood flow, saturation, stiffness, thickness, spring effect, deadband, inertia, damper effects, constant force, ramp force and friction.

22. The method of claim 5, where said cardiac sensor is composed of proprioceptive whiskers provided with strain gauges for the determination of at least two orthogonal components of movement of local tissues and fluid flow.

14. A method for designing a haptic control system contained within the handle of a catheter or virtual catheter for a cardiac sensor comprising providing an elongated catheter with a distal end, and providing said distal end with a microfabricated sensor that generates signals indicative of one or more dimensional motion sensed by said sensor;

and providing a response element that simulates the real time multi-dimensional motion of the distal end.

15. The method of claim 14 further comprising providing a dampening and/or release mechanism that mitigates the force generated on vascular or cardiac tissue as to prevent tissue damage.

16. A method of constructing an cardiac sensor comprising providing an elongated member having a distal end arranged and constructed for insertion about the heart and providing said distal end with a piezoelectric sensor generating an electrical signal proportional to the degree of sensor deformation along multiple vectors, wherein said electrical signal provides tactile feedback.

17. The method of claim 16 wherein said piezoelectric sensor includes carbon nanoconductors.

18. The method of claim 17 wherein said carbon nanoconductors are hybrid conductors including conventional electrical conductors.

19. An intra-cardiac delivery system comprising a needle arranged and constructed for puncturing the interatrial septum, said needle including an element having piezoelectric properties and generating an electrical signal related to a force upon the distal aspect of the needle.

20. A handheld delivery system comprising a needle having a piezoelectric sensor generating an electric signal related to a force applied to a tip of the needle and a haptic control system having a stimulator receiving said electrical signal and generating sensory signals corresponding to said force.

21. The system of claim 20, where said haptic control system is calibrated based on analogous data acquired from one or more of;

radiographic techniques, piezoelectric properties, electric and electromagnetic fields, extra-cardiac navigational systems, ultrasound technology.