MONITORING AND COMPENSATING FOR TEMPERATURE-RELATED ERROR IN AN ELECTROCHEMICAL SENSOR
First Claim
1. A method of compensating for temperature-related errors in an electrochemical sensor that outputs a current proportional to an analyte concentration when a voltage is applied to the sensor, the method comprising:
- measuring current output from the sensor;
lowering sensor voltage to a first voltage level below a reaction-sustaining threshold;
measuring an offset current corresponding to the first voltage level;
adjusting sensor voltage to a second voltage level below the reaction-sustaining threshold;
measuring an offset current corresponding to the second voltage level;
calculating a difference between the offset currents;
deriving a temperature compensation value based in part on the difference; and
adding the temperature compensation value to the measured current output to obtain an analyte concentration corrected for temperature.
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Abstract
A method for compensating for a temperature-related error in an electrochemical sensor without using separate sources of temperature measurement by measuring sensor current, temporarily lowering sensor voltage to a first level below a reaction-sustaining threshold, measuring a first offset current, adjusting sensor voltage to a second level below the threshold, measuring a second offset current, calculating a difference between the offset currents, deriving a temperature compensation value from the difference based on empirical data, and adding the value to the measured sensor current. A computer system may execute the method as an algorithm stored in memory, provide automatic control of the sensor, and provide continuous display of corrected output values.
137 Citations
25 Claims
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1. A method of compensating for temperature-related errors in an electrochemical sensor that outputs a current proportional to an analyte concentration when a voltage is applied to the sensor, the method comprising:
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measuring current output from the sensor; lowering sensor voltage to a first voltage level below a reaction-sustaining threshold; measuring an offset current corresponding to the first voltage level; adjusting sensor voltage to a second voltage level below the reaction-sustaining threshold; measuring an offset current corresponding to the second voltage level; calculating a difference between the offset currents; deriving a temperature compensation value based in part on the difference; and adding the temperature compensation value to the measured current output to obtain an analyte concentration corrected for temperature. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A system for compensating for temperature-related errors in an electrochemical sensor that outputs a current proportional to an analyte concentration when a voltage is applied to the sensor, comprising:
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a sensor having a working electrode; a potentiostat for adjusting voltage applied to the working electrode; a processor coupled to memory; and temperature compensation software stored in the memory and executable by the processor, wherein responsive to the processor executing the software, the potentiostat temporarily lowers the voltage of the working electrode below a reaction-sustaining threshold to obtain a temperature compensation value for correcting sensor output when the voltage of the working electrode is raised above the reaction-sustaining threshold. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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17. An apparatus for monitoring and compensating for temperature of an electrochemical sensors comprising:
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a sensor having a working electrode covered with a glucose oxidase enzyme; and a processor configured to transmit a first energization voltage that is below a reaction-sustaining threshold to the sensor, receive a first current value representing a temperature parameter measured by the sensor, determine a temperature compensation value based on the first current value, transmit a second energization voltage that is above the reaction-sustaining threshold to the sensor, and receive a second current value representing a sensor output. - View Dependent Claims (18, 19, 20)
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21. An apparatus for compensating for temperature of an electrochemical sensor, comprising:
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a flexible substrate; and an electrochemical sensor formed on the flexible substrate for sensing an analyte and outputting a signal that is used for compensating for temperature, wherein the analyte is hydrogen peroxide and the electrochemical sensor is coated with a glucose oxidase enzyme. - View Dependent Claims (22, 23, 24)
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25. A method for monitoring and compensating for temperature of an electrochemical sensor, comprising:
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transmitting a first energization voltage that is below a reaction-sustaining threshold to the sensor; receiving a first current value representing a temperature parameter measured by the sensor; determining a temperature compensation value based on the first current value; transmitting a second energization voltage that is above the reaction-sustaining threshold to the sensor; and receiving a second current value representing a sensor output.
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Specification