Receptacles and Kits, Such as for Dry Powder Packaging

• US 20090032427A1
• Filed: 09/26/2006
• Published: 02/05/2009
• Est. Priority Date: 09/29/2005
• Status: Abandoned Application

• Current Assignee: Novartis Pharma AG (Novartis Ag)
• Original Assignee: Nektar Therapeutics
• Inventors: Cheu, Scot, Chan, Leo
• Application Number:
  US12/083,079
• Publication Number:
  US 20090032427A1
• Time in Patent Office: Days
• US Class Current: 206/438
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/0033 Details of the piercing or cutting means
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/005 the dosages being arranged on a cylindrical surface
• CPC Class Codes: A61M 15/0051 the dosages being arranged on a tape, e.g. strips
• CPC Class Codes: A61M 15/0061 using pre-packed dosages having an insert inside
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2209/06 Packaging for specific medical equipment

Abstract

A receptacle (100) includes a holder (5) forming a cavity (25) that holds a pharmaceutical (110), a lid (15), and adhesive (17) that forms a bond (20) between the holder (5) and the lid (15). As an example, the bond (20) has a shape that includes a protrusion (30) that facilitates removal of the lid (15) from the holder (5). A kit (60) includes a plurality of containers containing powder including amphotericin B and pharmaceutically acceptable excipient. The kit (60) also includes an aerosolization apparatus (1100) and instructions. As an example, the pharmaceutical composition is made from panicles including amphotericin B having a mass median diameter less than about 3 μm, such as from about 1.1 μm to about 1.9 μm.

Claims

1. A receptacle, comprising:

a holder forming a cavity that holds a pharmaceutical;

a lid; and

adhesive that forms a bond between the holder and the lid, wherein the bond has a shape, and wherein the shape comprises a protrusion that facilitates removal of the lid from the holder.

2. The receptacle of claim 1, wherein the protrusion comprises an arc, a substantially straight line, or both.

3. The receptacle of claim 1, wherein the holder includes a substantially flat surface, the lid includes substantially flat surface, and said adhesive forms a bond between said substantially flat surfaces of the holder and the lid.

4. The receptacle of claim 3, wherein the substantially flat surface of the lid comprises an unbonded portion that facilitates removal of the lid from the holder.

5. The receptacle of claim 1, wherein the lid comprises a raised portion.

8. The receptacle of claim 1, wherein the receptacle is made by bonding a holder comprising adhesive to a lid.

9. The receptacle of claim 1, wherein the holder comprises a laminate comprising thermoplastic.

11. The receptacle of claim 1, wherein the lid comprises a metal foil, a paper, a laminate comprising thermoplastic, and combinations thereof.

12. The receptacle of claim 1, wherein the receptacle contains a capsule containing the pharmaceutical.

13. The receptacle of claim 12, wherein the pharmaceutical comprises amphotericin B.

16. The receptacle of claim 12, wherein the pharmaceutical comprises a hormone.

17. The receptacle of claim 16, wherein the hormone comprises a parthyroid hormone, fragment thereof, derivative thereof, analogs thereof, and combinations thereof.

19. The receptacle of claim 12, wherein the pharmaceutical comprises an anti-infective.

20. The receptacle of claim 19, wherein the anti-infective is an antibiotic.

21. The receptacle of claim 20, wherein the antibiotic is amikacin, gentamicin, vancomycin, tobramycin, ciprofloxacin, and combinations thereof.

22. The receptacle of claim 20, wherein the antibiotic is tobramycin.

24. An array, comprising a plurality of the receptacles of claim 1, wherein the plurality of receptacles are attached to each other.

25. The array of claim 24, wherein the array comprises a one-dimensional array.

26. The array of claim 24, wherein the array comprises a two-dimensional array.

27. The array of claim 24, wherein adjacent receptacles are separated by perforations.

28. The array of claim 24, wherein adjacent receptacles are separate by at least one score cut.

29. The array of claim 24, further comprising a backing on which the receptacles are mounted, wherein the backing is separable from the receptacles.

6-7. -7. (canceled)

10. (canceled)

14-15. -15. (canceled)

18. (canceled)

23. (canceled)

30-43. -43. (canceled)

44. A kit, comprising:

a plurality of containers containing powder comprising amphotericin B and pharmaceutically acceptable excipient;

an aerosolization apparatus; and

instructions,

wherein the pharmaceutical composition is made from particles comprising amphotericin B having a mass median diameter less than about 3 μ

m.

45. The kit of claim 44, wherein the plurality of containers comprise capsules.

46-53. -53. (canceled)