Composite scaffolds and methods using same for generating complex tissue grafts
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Abstract
A composite scaffold for engineering a heterogeneous tissue is provided. The composite scaffold includes: (a) a first scaffold being capable of supporting formation of a first tissue type thereupon; and (b) a second scaffold being capable of supporting formation of a second tissue type thereupon; wherein the first scaffold and the second scaffold are arranged with respect to each other such that when the first scaffold supports the first tissue type and the second scaffold supports the second tissue type, a distance between any cell of the second tissue type and the first tissue type does not exceed 200 μm.
23 Citations
88 Claims
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1-64. -64. (canceled)
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65. A method of inducing the formation of a heterogeneous tissue, the method comprising:
- (a) providing a first scaffold being capable of supporting formation of a first tissue type thereupon;
(b) providing a second scaffold being capable of supporting formation of a second tissue type thereupon;
(c) embedding said first scaffold in said second scaffold thereby forming a composite scaffold, wherein said first scaffold and said second scaffold are arranged with respect to each other such that when said first scaffold supports said first tissue type and said second scaffold supports said second tissue type, a distance between any cell of said second tissue type and said first tissue type does not exceed 200 μ
m; and
(d) contacting said composite scaffold with cells of said first tissue type and cells of said second tissue type. - View Dependent Claims (66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88)
- (a) providing a first scaffold being capable of supporting formation of a first tissue type thereupon;
Specification