MODIFIED CARBOCYANINE DYES AND THEIR CONJUGATES
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Abstract
Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
107 Citations
23 Claims
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2-1. The method of claim 1, wherein R12 is alkyl.
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20. A method for forming a dye-conjugate of a protein, peptide, or a nucleic acid polymer, said method comprising:
combining a dye solution comprising a compound of the formula;
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21. A kit for fluorescent labeling of a biological sample, comprising:
a dye solution comprising a compound having the formula; - View Dependent Claims (22)
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23. A composition comprising a compound having the formula:
Specification