MICROFLUIDIC RADIOSYNTHESIS SYSTEM FOR POSITRON EMISSION TOMOGRAPHY BIOMARKERS
First Claim
1. A microfluidic chip for radiosynthesis of a radiolabeled compound, comprising:
- a reaction chamber;
one or more flow channels connected to said reaction chamber;
one or more vents connected to said reaction chamber; and
one or more integrated valves to effect flow control in and out of said reaction chamber.
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Accused Products
Abstract
Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.
91 Citations
52 Claims
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1. A microfluidic chip for radiosynthesis of a radiolabeled compound, comprising:
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a reaction chamber; one or more flow channels connected to said reaction chamber; one or more vents connected to said reaction chamber; and one or more integrated valves to effect flow control in and out of said reaction chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. A portable device for automated radiosynthesis of a radiolabeled compound, comprising:
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a microfluidic chip; a reagent source comprising at least one reagent in fluid communication with said chip; a fluid delivery and removal network; a controller adapted to control the operation of said network; and localized radiation shielding for shielding one or more radiation critical components of said device. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
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51. A method for radiosynthesis of a radiolabeled compound, comprising;
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introducing one or more reagents into microfluidic chip, the chip comprising; a reaction chamber, one or more flow channels connected to said reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber; processing said reagent(s) to generate a radiolabeled compound; and collecting said radiolabeled compound.
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52. A program code embodied on a computer-readable medium, the program code comprising instructions for causing a controller to implement a method for radiosynthesis of a radiolabeled compound using a microfluidic chip, said method comprising:
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introducing one or more reagents into a reaction chamber; operating the synthesis system to process said reagent(s) responsive to a predetermined algorithm to generate a radiolabeled compound; and collecting said radiolabeled compound.
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Specification