SUBSTANCE SAMPLING AND/OR SUBSTANCE DELIVERY VIA SKIN

• US 20090036795A1
• Filed: 09/22/2006
• Published: 02/05/2009
• Est. Priority Date: 09/26/2005
• Status: Abandoned Application

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Duineveld, Paulus Cornelis, Voorhorst, Fokke Roelof, Sinnema, Anke, Schallig, Michel Allan Aurelius
• Application Number:
  US12/067,947
• Publication Number:
  US 20090036795A1
• Time in Patent Office: Days
• US Class Current: 600/570
• CPC Class Codes: A61B 10/0233 Pointed or sharp biopsy instruments
• CPC Class Codes: A61B 17/205 Vaccinating by means of needles or other puncturing devices
• CPC Class Codes: A61B 17/32053 Punch like cutting instruments, e.g. using a cylindrical or oval knife A61B17/326 takes precedence; trepans A61B17/1695; for use on the cornea A61F9/007
• CPC Class Codes: A61B 17/32093 for skin incisions
• CPC Class Codes: A61B 17/322 Skin grafting apparatus
• CPC Class Codes: A61B 2010/008 Interstitial fluid
• CPC Class Codes: A61B 2017/306 holding by means of suction
• CPC Class Codes: A61B 2090/064 for measuring force, pressure or mechanical tension
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/150068 by tissue compression, e.g. with specially designed surface of device contacting the skin area to be pierced
• CPC Class Codes: A61B 5/150099 by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
• CPC Class Codes: A61B 5/150175 Adjustment of penetration depth
• CPC Class Codes: A61B 5/150358 Strips for collecting blood, e.g. absorbent optical reagent test strips G01N21/8483; chemical reagent test strips G01N33/4875, G01N33/52
• CPC Class Codes: A61B 5/150389 Hollow piercing elements, e.g. canulas, needles, for piercing the skin
• CPC Class Codes: A61B 5/150442 Blade-like piercing elements, e.g. blades, cutters, knives, for cutting the skin
• CPC Class Codes: A61B 5/150977 Arrays of piercing elements for simultaneous piercing
• CPC Class Codes: A61B 5/157 Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: A61M 5/425 : Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means
• CPC Class Codes: A61M 5/427 : Locating point where body is to be pierced, e.g. vein location means using ultrasonic waves, injection site templates

Abstract

In a technique for substance sampling and/or substance delivery via the skin barrier, the skin is domed and then a portion removed. Typically a contact portion of the apparatus effects doming of the skin and a cutting, grazing or scraping arrangement removes a portion of the domed skin. The doming of the skin and hence the skin removal is closely controlled. Samples may be taken via the removed portion of the skin and/or substances delivered therethrough.

Claims

1. An apparatus for substance sampling and/or substance delivery via the skin barrier, the apparatus comprising means for doming and removing skin.

2. An apparatus according to claim 1, wherein the apparatus comprises contact means for contacting the skin, and including doming means for doming the skin;

and a skin removal arrangement arranged to pass adjacent and remove a layer of domed skin adjacent the doming means.

3. An apparatus according to claim 2, wherein the doming means comprises an aperture, the domed skin projecting through the aperture to be removed by means of the skin removal arrangement passing across the adjacent aperture.

4. An apparatus according to claim 3, wherein substance sampling and/or substance delivery is conducted via the dome forming aperture in the apparatus.

5. An apparatus according to claim 2, wherein the skin removal arrangement includes a blade or scraper element that passes across the doming means in a slice plane that is generally substantially parallel to the surface of the skin outside the domed skin zone.

6. An apparatus according to claim 1, including:

i) capture means for capturing a sample of fluid passing from the skin removal zone of the skin; and

/or

ii) assist means arranged to promote movement of the substance across the skin removal zone of the skin; and

/or

iii) analyser means for analysing a sampled substance; and

/or

iv) administration means for administration of a medicament via the opening in the skin; and

/or

v) securing means for securing to the body or a body part of an individual.

7. An apparatus according to claim 1, wherein the apparatus further includes a delivery or extraction conduit arranged to be inserted to penetrate into the opening of the skin.

8. An apparatus according to claim 1, including a non-invasive sampling arrangement for non-invasive sampling via the opening in the skin barrier without sampling of interstitial fluid.

9. An apparatus according to claim 1, including:

i) capture means for storage of a captured sample, the capture means (or one or more components thereof) being removable from the apparatus and disposable, to be replaced like for like; and

/or

ii) analyser means for analysing a sampled substance, he an analyser means (or one or more components thereof) being removable from the apparatus and disposable to be replaced like for like; and

/or

iii) administration means for administration of a medicament, the administration means (or one or more components thereof) being removable from the apparatus and disposable to be replaced like for like.

10. A method for sampling and/or substance delivery via the skin barrier, the method comprising doming the skin in a controlled manner and operating a skin removal arrangement to remove domed skin so forming an opening in the skin barrier;

and either sampling interstitial fluid or other substance present at the cut zone, and/or delivering a substance from externally of the skin through the cut zone.