Bioresorbable knit

• US 20090036907A1
• Filed: 07/30/2007
• Published: 02/05/2009
• Est. Priority Date: 07/30/2007
• Status: Abandoned Application

• Current Assignee: Sofradim Production SAS (Medtronic Plc)
• Original Assignee: Sofradim Production SAS (Medtronic Plc)
• Inventors: Montanari, Suzelei, Bayon, Yves, Gravagna, Philippe, Meneghin, Alfredo, Therin, Michel
• Application Number:
  US11/881,837
• Publication Number:
  US 20090036907A1
• Time in Patent Office: Days
• US Class Current: 606/151
• CPC Class Codes: A61L 27/38 containing added animal cells organs or tissue containing native cells A61L27/36
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: D04B 21/12 characterised by thread material
• CPC Class Codes: D10B 2401/12 biodegradable
• CPC Class Codes: D10B 2403/0112 One smooth surface, e.g. laminated or coated
• CPC Class Codes: D10B 2403/0122 Smooth surfaces, e.g. laminated or coated
• CPC Class Codes: D10B 2403/0213 with apertures, e.g. with one or more mesh fabric plies
• CPC Class Codes: D10B 2509/08 Hernia repair mesh

Abstract

Bioresorbable three-dimensional prosthetic knits include a first porous face and a second porous face, the first face and the second face each containing yarns made of materials which undergo slow bioresorption and being opposite and separated from one another by the thickness of the knit and being connected to one another by a spacer. The spacer includes yarns made of materials which undergo slow bioresorption and yarns made of material which undergoes rapid bioresorption.

Claims

1. A bioresorbable three-dimensional prosthetic knit comprising a first face and a second face, said first face and said second face being opposite and separated from one another by the thickness of said knit and being connected to one another by a spacer, said first face and said second face being porous, said first face and said second face comprising yarns made of material which undergoes slow bioresorption, characterized in that said spacer comprises yarns made of material which undergoes slow bioresorption and yarns made of material which undergoes rapid bioresorption.

2. A knit according to claim 1 wherein said first face and said second face are identical.

3. A knit according to claim 1 wherein the yarns made of material which undergoes rapid bioresorption define a first network of yarns, said first network having a first density.

4. A knit according to claim 1 wherein the yarns made of material which undergoes slow bioresorption define a second network of yarns, this second network having a second density.

5. A knit according to claim 3 wherein said first network and said second network define pores which are interconnected with one another.

6. A knit according claim 1 wherein the yarns made of material which undergoes slow bioresorption are chosen from yarns made of material selected from the group consisting of poly(lactic acid) (PLA), polycaprolactones (PCLs), polydioxanones (PDOs), trimethylene carbonates (TMCs), polyvinyl alcohol (PVA), polyhydroxyalkanoates (PHAs), polyamides, polyethers, copolymers of these materials, and mixtures thereof.

7. A knit according to claim 1 wherein the yarns made of material which undergoes rapid bioresorption are chosen from yarns made of material selected from the group consisting of oxidized cellulose, poly(glycolic acid) (PGA), poly(lactic acid) (PLA), polysaccharides, polycaprolactones (PCLs), polydioxanones (PDOs), trimethylene carbonates (TMCs), polyvinyl alcohol (PVA), polyhydroxyalkanoates (PHAs), polyamides, polyethers, copolymers of these materials, and mixtures thereof.

8. A knit according claim 1 wherein the yarns made of material which undergoes rapid bioresorption are yarns made of regenerated and oxidized cellulose.

9. A knit according to claim 7 wherein the polysaccharides are selected from the group consisting of hyaluronic acid, alginic acid, poly(glucuronic acid), chitosan, soluble cellulose derivatives, salts of these compounds, derivatives thereof and mixtures thereof.

10. A knit according to claim 1 wherein the yarns made of material which undergoes slow bioresorption that are used for the spacer are monofilament yarns.

11. A knit according to claim 10 wherein the count of the monofilament yarns made of material which undergoes slow bioresorption ranges from 200 to 500 dtex.

12. A knit according to claim 1 wherein the yarns made of material which undergoes rapid resorption are multifilament yarns.

13. A knit according to claim 1 wherein the count of the multifilament yarns made of material which undergoes rapid bioresorption ranges from 50 to 300 dtex.

14. A knit according to claim 1 wherein said knit has a two-dimensional porosity of less than or equal to 20%.

15. A knit according to claim 1 wherein said network of yarns which undergo slow bioresorption has a three-dimensional porosity of greater than or equal to 80%.

16. A knit according to claim 1 wherein said three-dimensional knit has a thickness ranging from approximately 2 mm to 6 mm.

17. A knit according to claim 1 wherein said knit is isoelastic.

18. A knit according to an claim 1 wherein said knit has a mechanical strength in the longitudinal direction, measured according to ISO standard 13934-1, ranging from 50 to 300 N.

19. A knit according to claim 1 wherein said knit has a mechanical strength in the transverse direction, measured according to ISO standard 13934-1, ranging from 50 to 300 N.

20. A knit according to claim 18 wherein said knit has a mechanical strength in the longitudinal direction, measured according to ISO standard 13934-1, ranging from 100 to 250 N.

21. A knit according to claim 19 wherein said knit has a mechanical strength in the transverse direction, measured according to ISO standard 13934-1, ranging from 75 to 200 N.

22. A knit according to claim 1 wherein said knit has an elongation at 50 N in the longitudinal direction, measured according to ISO standard 13934-1, ranging from 10% to 50%.

23. A knit according to claim 1 wherein said knit has an elongation at 50 N in the transverse direction, measured according to ISO standard 13934-1, ranging from 10% to 50%.

24. A knit according to claim 1 wherein at least a part of the yarns constituting said three-dimensional knit are coated with a bioresorbable coating.

25. A knit according to claim 24, characterized in that said coating is chosen from collagen, polysaccharides and mixtures thereof.

26. A knit according to claim 1 further comprising one or more active compounds selected from the group consisting of antiseptics, anti-inflammatories, growth factors, sulphated polysaccharides such as fucans, extracellular matrix proteins such as fibronectin, laminin, elastin, glycosaminoglycans or proteoglycans, and mixtures thereof.

27. A knit according to claim 1 further comprising a bioresorbable film on at least one of its faces.

28. A knit according to claim 27 wherein the film comprises at least one collagen.

29. A knit according to claim 27 wherein the film comprises oxidized collagen, polyethylene glycol and glycerol.

30. A knit according to claim 1 which is seeded with live cells.

31. A knit according to claim 30 which is seeded with cells selected from the group consisting of:

striated muscle cells, smooth muscle cells, endothelial cells, epithelial cells, mesothelial cells, fibroblasts, myofibroblasts, and stem cells of each of the above cell types, and combinations thereof.

32. A tissue engineering support that comprises at least one knit according to claim 1.

33. A tissue engineering support according to claim 32 seeded with live cells.

34. A tissue engineering support according to claim 33 which is seeded with cells selected from the group consisting of:

striated muscle cells, smooth muscle cells, endothelial cells, epithelial cells, mesothelial cells, fibroblasts, myofibroblasts, and stem cells of each of the above cell types, and combinations thereof.

35. Use of a knit according to claim 1 for culturing live cells.

36. A process for manufacturing a knit according to claim 1 in which at least part of the yarns made of material which undergoes rapid bioresorption are made of oxidized cellulose, characterized in that it comprises at least the following steps:

a^o) the knit is produced on a knitting machine with yarns, at least part of the yarns being made of nonoxidized cellulose,

b^o) the knit produced in step a^o) is submitted to an oxidation step.

37. A process according to claim 36 wherein the oxidation step is carried out with NO₂.

38. A process according to claim 36 wherein the oxidation step is carried out with sodium periodate.