SELF-SENSING STENTS, SMART MATERIALS-BASED STENTS, DRUG DELIVERY SYSTEMS, OTHER MEDICAL DEVICES, AND MEDICAL USES FOR PIEZO-ELECTRIC MATERIALS

• US 20090036975A1
• Filed: 12/12/2006
• Published: 02/05/2009
• Est. Priority Date: 12/12/2005
• Status: Abandoned Application

• Current Assignee: Virginia Commonwealth University
• Original Assignee: Virginia Commonwealth University
• Inventors: Ounaies, Zoubeida, Vetrovec, George, Ward, Kevin
• Application Number:
  US12/097,103
• Publication Number:
  US 20090036975A1
• Time in Patent Office: Days
• US Class Current: 623/1.180
• CPC Class Codes: A61B 2560/0214 of power generation or supply
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2300/424 Anti-adhesion agents
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61N 1/3785 generated by biological activity or substance, e.g. body movement

Abstract

A medically implantable stent comprising at least one piezo-electric material may be active, such as by one or more of: delivering an anti-coagulant or other therapeutic effect to a patient in which it is implanted; powering itself; and/or sending an outbound electronic signal to a remote device. When a stent can send such an outbound signal, a physician may non-invasively ascertain the condition of the tissue near the stent.

Claims

1. An anti-coagulative and/or antiadhesive stent comprising:

a stent implantable into a living patient, the stent comprising at least one negative-charge-producing surface, and the stent delivering an anticoagulant effect and/or an antiadhesive effect to the patient in which the stent is implanted.

2. The stent of claim 1, comprising at least one signal-producing component.

3. The stent of claim 2, wherein the signal-producing component produces a recordable signal.

4. The stent of claim 1, comprising a piezo-electric material.

5. The stent of claim 1, wherein the at least one negative-charge-producing surface comprises at least one piezo-electric material orientation of which is arranged to produce a certain negative charge.

6. The stent of claim 1, comprising a drug-eluting stent.

7. The stent of claim 1, comprising a smart stent.

8. The stent of claim 1, comprising a signal-transmitter transmitting an electrical signal a distance in a range of about 1 to 2 feet or more.

9. The stent of claim 1, comprising a recordable voltage output, wherein the recordable voltage output is proportional to at least one function or property of a tissue where the stent is situated.

10. The stent of claim 9, wherein the at least one function or property is selected from the group consisting of:

flow, pressure, force, and temperature.

11. The stent of claim 1, comprising at least one piezo-electric material and a recordable voltage output from interaction between the piezo-electric material and a material in contact with the piezo-electric material.

12. The stent of claim 1, comprising a self-powered stent.

13. The stent of claim 12, comprising at least one pharmaceutical substance or other substance releasable from the stent and a releasing mechanism for releasing the substance wherein the releasing mechanism is powered by interaction of a piezoelectric material with a tissue in which the stent is situated.

14. The stent of claim 1, comprising at least one selected from the group consisting of PVDF;

copolymers of PVDF with trifluoroethylene (TrFE), tetrafluoroethylene (TFE), PVDF carbon nanotube composites, PVDF nanoclay composites, lead-zirconium-titanate ceramic.

15. The stent of claim 1, comprising a voltage controller controlling application of voltage.

16. A method of producing an anticoagulant effect and/or an antiadhesive effect in a patient, comprising a step of:

implanting in the patient a stent comprising a negative-charge-producing surface.

17. The method of claim 16, wherein the stent comprises a piezo-electric material.

18. The method of claim 16, wherein the implanting step comprises implanting a drug-eluting stent.

19. The method of claim 16, wherein the implanting step comprises implanting a stent selected from the group consisting of a cardiac stent;

a coronary artery stent;

a vascular stent;

an airway stent;

a gastrointestinal stent; and

a urologic stent.

20. The method of claim 16, wherein the implanting step comprises implanting a smart stent.

21. The method of claim 16, wherein the stent comprises at least one selected from the group consisting of PVDF;

copolymers of PVDF with trifluoroethylene (TrFE), tetrafluoroethylene (TFE), PVDF carbon nanotube composites, PVDF nanoclay composites, and lead-zirconium-titanate ceramic.

23. The smart stent system of claim 21, wherein the receiver is wireless and is coupled either directly or wirelessly to a filter, an amplifier and a monitor.

22. A smart stent system, comprising:

(a) a smart stent implantable into a living patient, comprising a piezo-electric material and producing a recordable signal; and

(b) a signal receiver physically separate from the smart stent and receiving the recordable signal from the smart stent at a distance in a range of about 1 to 2 or more feet.

24. The smart stent system of claim 22, where in the monitor is selected from the group consisting of a computer and a person al digital assistant device.

25. The smart stent system of claim 22, wherein the smart stent comprises at least one passive component selected from the group consisting of:

a diode bridge to control voltage swings and a voltage regulator.

26. The smart stent system of claim 22, wherein the smart stent comprises a high density rechargeable battery, a filter, an amplifier, and an A/D converter (microcontroller).

27. The smart stent system of claim 22, wherein an electrical output of the piezoelectric material charges the battery and/or powers at least one component of the stent.

28. The smart stent system of claim 22, comprising a recordable voltage output sent by the stent, wherein the recordable voltage output is proportional to at least one function or property of a tissue where the stent is situated.

29. The smart stent system of claim 22, wherein the stent comprises at least one piezo-electric material, and the system comprises a recordable voltage output from interaction between the piezo-electric material and a material in contact with the piezo-electric material.

30. The smart stent system of claim 22, wherein the stent is self-powered.

31. The smart stent system of claim 22, comprising within the stent at least one substance releasable from the stent, further comprising a releasing mechanism for releasing the substance wherein the releasing mechanism is powered by interaction of a piezoelectric material with a tissue in which the stent is situated.

32. The smart stent system of claim 22, comprising a stent selected from the group consisting of:

a negative-charge-producing stent;

an anticoagulant stent;

an antiadhesive stent;

a positive-charge producing stent;

a positive-charge-producing stent;

a procoagulant stent; and

a proadhesive stent.

33. A stent comprising:

a piezo-electric material, the stent being self-powered without needing a separate power source when the stent is implanted in a living patient.

34. The stent of claim 33, wherein the stent interferes with undesirable clotting in a patient in which the stent has been implanted.

35. The stent of claim 33, comprising a signal-sender which sends an electronic signal to a location external from the stent, the signal comprising clotting-related information.

36. The stent of claim 33, comprising a recordable voltage output, wherein the recordable voltage output is proportional to at least one function or property of a tissue where the stent is situated.

37. The stent of claim 33, comprising at least one piezo-electric material and a recordable voltage output from interaction between the piezo-electric material and a material in contact with the piezo-electric material.

38. The stent of claim 33, further comprising at least one substance releasable from the stent, and a releasing mechanism for releasing the substance wherein the releasing mechanism is powered by interaction of a piezoelectric material with a tissue in which the stent is situated.

39. The stent of claim 33, comprising a stent selected from the group consisting of:

a negative-charge-producing stent;

an anticoagulant stent;

an antiadhesive stent;

a positive-charge producing stent;

a positive-charge-producing stent;

a procoagulant stent; and

a proadhesive stent.

40. A method of constructing a smart stent system, comprising the steps of:

(a) forming an implantable self-powered stent structure comprising at least one piezo-electric material, and implantable into a patient, the stent structure formed to produce a signal comprising a recordable voltage output proportional to at least one function or property of a tissue where the stent is to be situated;

(b) constructing a receiving device that receives the recordable voltage output produced by the stent structure, wherein the receiving device may be separate from the implantable stent structure.

41. The method of claim 40, further comprising:

forming in the stent a reservoir for holding a releasable pharmaceutical or other substance and having a release mechanism powered by power generated by the piezo-electric material which power may be used directly or stored or converted before being used to power the release mechanism.

42. The method of claim 40, comprising:

arranging orientation of the at least one piezo-electric material to produce a certain negative charge or positive charge.

43. A drug delivery system, comprising:

a container comprising at least one piezo-electric material, the container comprising a cavity for holding an amount of a drug to be released into a patient, wherein the container is implantable in a living patient.

44. The drug delivery system of claim 43, comprising a drug.

45. The drug delivery system of claim 43, further comprising an electronic signal that is based on an interaction of the piezo-electronic material with a tissue of the patient and that is outbound to a remote device.

46. The drug delivery system of claim 43, comprising a remote control system by which a physician may remotely control at least one parameter relating to release of the drug contained in the container.

47. The drug delivery system of claim 46, wherein the parameter controlled is selected from the group consisting of:

number of apertures through which the drug may release;

size of apertures through which the drug is released;

shape of apertures through which the drug releases.

48. A method of myocardial monitoring, pulmonary artery monitoring, carotid artery monitoring, or cerebral artery monitoring in a patient, comprising:

(a) implanting in the patient a stent, (b) receiving from the stent electronic signals.

49. The method of claim 48, wherein the receiving step comprises receiving from the stent electronic signals relevant to one selected from the group consisting of:

myocardial function, myocardial pressure, myocardial temperature, pulmonary artery function, pulmonary artery pressure, pulmonary artery flow, pulmonary artery temperature, carotid artery function, carotid artery pressure, carotid artery flow, cerebral artery function, cerebral artery pressure, cerebral artery flow and cerebral artery temperature in the patient.

50. The method of claim 49, wherein the stent comprises at least one piezo-electric material.

51. The method of claim 49, wherein the stent is self-powered.

52. An energy-harvesting device comprising:

an energy harvesting structure comprising at least one piezoelectric material situatable in a region of a biologic structure; and

at least one energy conversion or storage component receiving energy from an interaction of the at least one piezoelectric material with a biologic structure.

53. The energy-harvesting device of claim 53, comprising a stent.

54. The energy-harvesting device of claim 53, comprising a piezoelectric film.

55. The energy-harvesting device of claim 53, comprising a wrapping wrappable around an artery or other biologic structure.

56. The energy-harvesting device of claim 53, wherein the biologic structure is within a living patient.

57. The energy-harvesting device of claim 53, further comprising a monitoring component whereby at least one function of the biologic structure is reportable via an electronic signal.

58. The energy-harvesting device of claim 53, wherein at least one selected from the group consisting of flow, pressure and temperature of the biologic structure is reported via an electronic signal to a device outside a patient in which the biologic structure is situated.

59. An energy-harvesting method, comprising:

situating at least one piezo-electric material on, in or near a biologic structure whereby a piezo-electric interaction occurs in which energy is generated; and

converting the energy generated from the piezo-electric interaction into a storable energy and/or an energy useable as power.