SYSTEM AND METHODS OF CHEMISTRY PATTERNING FOR A MULTIPLE WELL BIOSENSOR
First Claim
Patent Images
1. A biosensor, comprising:
- a base layer;
a first capillary disposed on the base layer configured to electrochemically determine a concentration of a first analyte in a blood sample, wherein the first capillary includes a first set of electrodes;
a second capillary disposed on the base layer configured to determine a value correlating to a second analyte in the blood sample, wherein the second capillary includes a second set of electrodes; and
a reagent layer disposed on the base layer, wherein the reagent layer is at least partially within the first capillary.
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Abstract
Methods and systems for measuring the concentration of an analyte in a blood sample and, more particularly, to methods of chemistry patterning reagent layers for multiple well biosensors. A first capillary is first configured to receive a dispensed reagent layer such that the reagent layer is distributed in a substantially uniform manner within the first capillary. The first capillary may also configured to isolate the first capillary from other capillaries present in the biosensor. After the reagent layer has been dispensed and dried, the first capillary may then be reconfigured to allow the first capillary to receive a blood sample.
34 Citations
76 Claims
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1. A biosensor, comprising:
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a base layer; a first capillary disposed on the base layer configured to electrochemically determine a concentration of a first analyte in a blood sample, wherein the first capillary includes a first set of electrodes; a second capillary disposed on the base layer configured to determine a value correlating to a second analyte in the blood sample, wherein the second capillary includes a second set of electrodes; and a reagent layer disposed on the base layer, wherein the reagent layer is at least partially within the first capillary. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A method for manufacturing a biosensor, comprising:
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at least partially forming a plurality of electrodes on a generally planar base layer; forming a first capillary on the base layer, wherein the first capillary includes a first set of at least one electrode selected from the plurality of at least partially formed electrodes; forming a second capillary on the base layer, wherein the second capillary includes a second set of at least one electrode selected from the plurality of at least partially formed electrodes; and forming a reagent layer on the base layer and at least partially within the first capillary. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
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52. A reel for manufacturing biosensors, comprising:
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a generally planar base layer including a plurality of at least partially formed electrodes; a first capillary on the base layer, wherein the first capillary includes a first set of electrodes selected from the plurality of at least partially formed electrodes and a reagent layer; a second capillary on the base layer, wherein the second capillary includes a second set of at least one electrode selected from the plurality of at least partially formed electrodes; and a reagent layer disposed on the base layer, wherein the reagent layer is at least partially within the first capillary. - View Dependent Claims (53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74)
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75. A method for manufacturing a plurality of test strips for a biosensor, comprising:
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forming a reel containing a base layer; forming a plurality of electrodes of the base layer; partially forming a test strip, wherein the test strip includes a first capillary on the base layer including at least one of the plurality of electrodes and the test strip further includes a second capillary on the base layer including at least one of the plurality of electrodes; and forming a reagent layer disposed on the base layer, wherein the reagent layer is at least partially within the first capillary.
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76. A test card for quality control analysis of biosensors, comprising:
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a base layer, wherein the base layer includes a plurality of electrodes; a plurality of partially formed test strips, wherein each test strip includes a first capillary on the base layer including at least one of the plurality of electrodes and each test strip further includes a second capillary on the base layer including at least one of the plurality of electrodes; and a reagent layer disposed on the base layer, wherein the reagent layer is at least partially within the first capillary.
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Specification