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Compositions and methods relating to glucagon receptor antibodies

  • US 20090041784A1
  • Filed: 09/20/2007
  • Published: 02/12/2009
  • Est. Priority Date: 09/20/2006
  • Status: Active Grant
First Claim
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1. An isolated antigen binding protein comprising an amino acid sequence selected from the group consisting of:

  • a. a light chain CDR3 comprising a sequence selected from the group consisting of;

    i. a light chain CDR3 sequence that differs by no more than a total of three amino acid additions, substitutions, and/or deletions from a CDR3 sequence selected from the group consisting of the light chain CDR3 sequences of L1-L23, SEQ ID NOs;

    72;

    74, 76, 78, 80, 83, 85, 87, 89, 91, 93, 95, 97, 100;

    ii. L Q X21 N S X22 P L T (SEQ ID NO;

         208); and

    iii. Q A W D S X23 T V X24 (SEQ ID NO;

    209);

    b. a heavy chain CDR3 sequence comprising a sequence selected from the group consisting of;

    i. a heavy chain CDR3 sequence that differs by no more than a total of four amino acid additions, substitutions, and/or deletions from a CDR3 sequence selected from the group consisting of the heavy chain CDR3 sequences of H1-H23, SEQ ID NOs;

    165, 167, 169, 171, 173, 175, 177, 179, 181, 183, 185, 187, 189, 191, 193, 195, 197, 199;

    ii. E X25 X26 X27 Y D I L T G Y X28 X29 Y Y G X30 D V (SEQ ID NO;

         210); and

    iii. X31 G G G F D Y (SEQ ID NO;

    211);

    orc. the light chain CDR3 sequence of (a) and the heavy chain CDR3 sequence of (b);

    wherein,X21 is a histidine residue, or a glutamine residue,X22 is an asparagine residue, an aspartate residue, or a tyrosine residue,X23 is an asparagine residue or a serine residue,X24 is an isoleucine residue or a valine residue,X25 is a lysine residue, a glutamate residue, or a proline residue,X26 is an aspartate residue, a threonine residue, a glutamine residue, or a proline residue,X27 is a histidine residue or a tyrosine residue,X28 is an asparagine residue, a histidine residue, an aspartate residue, or a phenylalanine residue,X29 is a tyrosine residue, a histidine residue, or an asparagine residue,X30 is a leucine residue or a methionine residue,X31 is a leucine residue or a methionine residue,and wherein said antigen binding protein specifically binds to the human glucagon receptor.

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