Biosensor Detection By Means Of Droplet Driving, Agitation, and Evaporation
First Claim
1. A method for improving sensor detection of target molecules in a sample within a fluidic system comprising the steps of breaking the sample into a series of discrete droplets and moving each discrete droplet over a sensing site of a sensor thereby improving detection by furnishing multiple signals from the sensor.
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Abstract
Methods of improving microfluidic assays are disclosed. Assays can be improved (better signal to noise ratio) by using sessile drop evaporation as an analyte concentration step (enhanced signal) and repeated passes of wash droplets as a means to reduce non-specific binding (noise reduction). In addition multiple massively parallel analyses improve the statistical precision of the analyses.
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Citations
13 Claims
- 1. A method for improving sensor detection of target molecules in a sample within a fluidic system comprising the steps of breaking the sample into a series of discrete droplets and moving each discrete droplet over a sensing site of a sensor thereby improving detection by furnishing multiple signals from the sensor.
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13. A method for improving sensor detection of target molecules in a sample within a fluidic system comprising the steps of:
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breaking the sample into a series of discrete droplets; providing a plurality of sensing sites in parallel; and moving each discrete droplet over each sensing site of the plurality thereby improving statistical accuracy of detection.
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Specification