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ANTIVIRAL OLIGONUCLEOTIDES TARGETING HBV

  • US 20090042827A1
  • Filed: 07/10/2008
  • Published: 02/12/2009
  • Est. Priority Date: 09/13/2002
  • Status: Active Grant
First Claim
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1. An antiviral pharmaceutical composition comprising a therapeutically effective amount of at least one pharmacologically acceptable antiviral oligonucleotide of at least 30 nucleotides in length, and a pharmaceutically acceptable carrier, wherein said composition targets a hepatitis virus selected from the group consisting of HBV and HCV, wherein said oligonucleotide comprises at least one phosphorothioate linkage, is not complementary to any portion of a genome sequence of a virus or of a viral mRNA, and the antiviral activity of said oligonucleotide occurs principally by a sequence independent mode of action.

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