MICRONEEDLE ARRAYS FORMED FROM POLYMER FILMS
First Claim
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1. A transdermal delivery device, comprising:
- a polymer layer having microneedles projecting from a surface thereof, wherein the microneedles are compositionally homogenous with the polymer base layer.
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Abstract
The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer.
84 Citations
28 Claims
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1. A transdermal delivery device, comprising:
a polymer layer having microneedles projecting from a surface thereof, wherein the microneedles are compositionally homogenous with the polymer base layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of manufacturing a transdermal drug delivery device having a microneedle array, comprising:
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providing a substrate; applying a polymer solution to the substrate to form a base layer disposing an exposed surface of the base layer with a textured surface having elevated points protruding there from such that the elevated points contact the exposed surface of the base layer; distancing the textured surface from the exposed surface of the base layer such that the elevated points draw out tube-like projections from the exposed surface of the base layer; and drying the base layer having the tube-like projections to form microneedles cutting the base layer to form the transdermal drug delivery device. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method of administering an active agent transdermally, comprising,
providing a transdermal patch device having a polymer base layer with microneedles projecting from a surface thereof, wherein the microneedles are compositionally homogenous with the base polymer layer, wherein said transdermal patch device contains an active agent; - and
applying said transdermal patch to a skin surface of a subject. - View Dependent Claims (23, 24, 25, 26, 27, 28)
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Specification