MONOPOLAR ENERGY DELIVERY DEVICES AND METHODS FOR CONTROLLING CURRENT DENSITY IN TISSUE

• US 20090043301A1
• Filed: 08/08/2008
• Published: 02/12/2009
• Est. Priority Date: 08/09/2007
• Status: Abandoned Application

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Asthmatx, Inc. (Boston Scientific Corporation)
• Inventors: Phan, Huy, Jarrard, Jerry, Epstein, Scott
• Application Number:
  US12/188,782
• Publication Number:
  US 20090043301A1
• Time in Patent Office: Days
• US Class Current: 606/41
• CPC Class Codes: A61B 18/1206 Generators therefor
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2018/00023 closed, i.e. without wound contact by the fluid
• CPC Class Codes: A61B 2018/00065 porous
• CPC Class Codes: A61B 2018/00113 with foam
• CPC Class Codes: A61B 2018/0016 Energy applicators arranged in a two- or three dimensional array
• CPC Class Codes: A61B 2018/00214 Expandable means emitting energy, e.g. by elements carried thereon
• CPC Class Codes: A61B 2018/0022 Balloons
• CPC Class Codes: A61B 2018/00238 porous
• CPC Class Codes: A61B 2018/00541 Lung or bronchi
• CPC Class Codes: A61B 2018/1253 monopolar
• CPC Class Codes: A61B 2018/1472 for use with liquid electrolyte, e.g. virtual electrodes
• CPC Class Codes: A61B 2018/1861 with an instrument inserted into a body lumen or cavity, e.g. a catheter
• CPC Class Codes: A61B 2218/002 Irrigation

Abstract

Devices, systems and methods for providing energy to treat large areas of tissue. Several embodiments of the devices control resistance or other parameters to provide substantially uniform current density along a length of tissue with reduced edge effects.

Claims

1. An energy delivery device for use in a body conduit or cavity, the device comprising:

an elongated body having a proximal portion and a distal portion; and

an energy applicator at the distal portion of the elongated body, wherein the energy applicator has a proximal area, a distal area, and a medial area between the proximal and distal areas, and wherein the energy applicator is configured to deliver a first voltage at the proximal and distal areas and a second voltage greater than the first voltage at the medial area.

2. The device of claim 1, wherein the energy applicator further comprises an expandable member.

3. The device of claim 2, wherein the expandable member comprises a balloon through which a conductive fluid can pass, and wherein the proximal and distal areas have a first physical property configured to create a first resistance and the medial area has a second physical property configured to create a second resistance less than the first resistance.

4. The device of claim 2, wherein the expandable member comprises a balloon through which a conductive fluid can pass, and wherein the balloon has a first porosity at the proximal and distal areas and a second porosity greater than the first porosity at the medial area such that resistance is greater in the proximal and distal areas than in the medial area.

5. The device of claim 4, wherein the proximal and distal areas have first pores and the medial area has second pores larger than the first pores.

6. The device of claim 2, wherein the expandable member comprises a balloon through which a conductive fluid can pass, and wherein the balloon has a first wall thickness at the proximal and distal areas and the medial area has a second wall thickness less than the first wall thickness.

7. The device of claim 2, wherein the expandable member comprises a self-expanding foam element through which a conductive fluid can pass, and wherein the proximal and distal areas have a first physical property configured to create a first resistance and the medial area has a second physical property configured to create a second resistance less than the first resistance.

8. The device of claim 2, wherein the expandable member comprises a self-expanding foam element through which a conductive fluid can pass, and wherein the foam element has first foam segments with a first porosity at the proximal and distal areas and a second foam segment at the medial area with a second porosity greater than the first porosity such that resistance is greater at the proximal and distal areas than the medial area.

9. The device of claim 8, wherein the proximal and distal areas have first pores and the medial area has second pores larger than the first pores.

10. The device of claim 2, wherein the expandable member comprises a self-expanding foam element through which a conductive fluid can pass, and wherein the foam element has first foam segments with a first thickness at the proximal and distal areas and a second foam segment at the medial area with a second thickness less than the first thickness.

11. The device of claim 2, wherein the expandable member comprises a balloon or foam element through which a conductive fluid can pass and the energy applicator further comprises a conductive emitter within the expandable member having first outlets in the proximal and distal areas and second outlets in the medial area, and wherein the first and second outlets are configured to provide different fluid flow characteristics through the balloon or foam element in the medial area compared to the proximal and distal areas.

12. The device of claim 2, wherein the energy applicator further comprises an energy conductor at the expandable member.

13. The device of claim 12, wherein the energy conductor comprises a first electrode at the proximal and distal areas, a first resistor having a first resistance coupled to the first electrodes, a second electrode at the medial area, and a second resistor having a second resistance less than the first resistance coupled to the second electrode.

14. The device of claim 2, wherein the expandable member comprises a conductive foam element or metallic array having a first resistance at the proximal and distal areas and a second resistance less than the first resistance at the medial area.

15. An energy delivery device for use in a body conduit or cavity, the device comprising:

an elongated body having a proximal portion and a distal portion;

an expandable member at the distal portion of the elongated body; and

an energy conductor at the expandable member, wherein the expandable member and the energy conductor are configured to vary an electrical conductivity along an axial length of the energy conductor so as to achieve a substantially uniform current density along a length of tissue.

16. The device of claim 15, wherein the expandable member and the energy conductor are configured to provide a first voltage at proximal and distal areas of the expandable member and a second voltage greater than the first voltage at a medial area of the expandable member.

17. The device of claim 15, wherein the energy conductor comprises first conductive segments at proximal and distal areas of the expandable member, a second conductive segment at a medial area of the expandable member, first resistors coupled to the first conductive segments, and a second resistor coupled to the second conductive segment, wherein the first resistors have a higher resistance than the second resistor.

18. The device of claim 15, wherein the energy conductor comprises a conductive fluid and the expandable member comprises one of a non-conductive balloon or foam element through which the conductive fluid can pass, wherein the one of the balloon or foam element has proximal and distal areas and a medial area between the proximal and distal areas, and wherein the medial area is configured to deliver a different amount of energy than the proximal and distal areas.

19. The device of claim 18, wherein the one of the balloon or foam element has first pores with first diameters at the proximal and distal areas and second pores with second diameters greater than the first diameters at the medial area.

20. The device of claim 18, wherein the one of the balloon or foam element has a first thickness at the proximal and distal areas and a second thickness at the medial area, and wherein the first thickness is greater than the second thickness.

21. The device of claim 18, further comprising a fluid conduit connected to the one of the balloon or foam element for the delivery of the conductive fluid.

22. A method for treating an internal airway in a lung of a patient, the method comprising:

positioning an elongated body of a treatment device in a lung airway of a patient;

expanding an energy applicator at a distal portion of the elongated body to contact a wall of the lung airway; and

delivering energy to the wall of the airway by varying an electrical conductivity along an axial length of the energy applicator so as to reduce edge effects along a length of target tissue.

23. The method of claim 22, wherein delivering comprises applying a first voltage to proximal and distal areas of the energy applicator and a second voltage greater than the first voltage to a medial area of the energy applicator.

24. The method of claim 22, wherein delivering comprises passing a conductive fluid through the energy applicator.

25. The method of claim 22, wherein delivering comprising applying current in a monopolar fashion.

26. The method of claim 22, wherein delivering comprises circumferentially and longitudinally heating tissue.

27. The method of claim 22, wherein expanding comprises inflating, self-expanding, or mechanically actuating the energy applicator.

28. The method of claim 22, wherein the target tissue comprises smooth muscle tissue.

29. The method of claim 22, further comprising cooling a tissue layer adjacent the target tissue.

30. The method of claim 29, wherein the adjacent layer comprises epithelial tissue.