Coatings for promoting endothelization of medical devices
First Claim
1. A coating, on a medical device, configured to promote formation of a protective matrix layer of a body'"'"'s own tissue in situ and in vivo.
2 Assignments
0 Petitions
Accused Products
Abstract
A unique method and coatings are provided for promoting tissue encapsulation of medical devices, especially before antiproliferative drug therapy within a body of a patient in order to prevent excessive restenosis and while avoiding thrombosis (including late stage/stent thrombosis). The method involves delaying the activation of restenosis suppressing (i.e. antiproliferative) drugs in the vicinity of the medical device until a thin layer of geometrically streamlined tissue has deposited itself upon the device. Coatings of one or more layer that provide an aligned scaffolding (i.e. via aligned fibers or aligned grooves) may be used in the method to encourage tissue deposition and/or to delay elution of drug(s) stored beneath or within. The delay phase prior to degradation, erosion, and/or absorption of the coating to release an active drug should last until an optimal amount of controlled restenosis has provided a thin endothelial layer to encapsulate the device.
94 Citations
70 Claims
- 1. A coating, on a medical device, configured to promote formation of a protective matrix layer of a body'"'"'s own tissue in situ and in vivo.
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46. A stent for implantation in a narrowed region of a blood vessel is coated with:
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(i) a primer layer; (ii) a layer comprising at least one antiproliferative or immunosuppressant drug; and (iii) a layer comprising aligned elements for delaying an onset of release of the antiproliferative or immunosuppressant drug, wherein the aligned elements are selected from the group consisting of;
nanofibers, microfibers, nanogrooves, microgrooves, and any combination of the aforementioned elements.
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47. A method for delaying activation of an antiproliferative or an immunosuppressant drug around a medical device implanted within a body until after:
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(i) 5-60 days have elapsed from medical device implantation; and (ii) the medical device has been encapsulated by a thin layer of the body'"'"'s own tissue. - View Dependent Claims (48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67)
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- 68. A method of coating a drug eluting stent with tissue in vivo by intentionally allowing restenosis around the stent until a thin layer of tissue coats the stent.
Specification