SYSTEM AND METHOD FOR ANALYTE MEASUREMENT USING DOSE SUFFICIENCY ELECTRODES
First Claim
Patent Images
1. A method of determining a dose sufficiency in a test strip for performing a measurement on a biological fluid, comprising:
- providing a biological fluid test strip comprising;
a capillary fill chamber extending a length along the test strip,at least two measurement electrodes in operative communication with the chamber, andat least two dose sufficiency electrodes in operative communication with the chamber;
applying the biological fluid to the test strip;
applying a dose sufficiency test signal having an AC component to at least one of the dose sufficiency electrodes; and
measuring a response to the dose sufficiency test signal.
6 Assignments
0 Petitions
Accused Products
Abstract
A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.
-
Citations
70 Claims
-
1. A method of determining a dose sufficiency in a test strip for performing a measurement on a biological fluid, comprising:
-
providing a biological fluid test strip comprising; a capillary fill chamber extending a length along the test strip, at least two measurement electrodes in operative communication with the chamber, and at least two dose sufficiency electrodes in operative communication with the chamber; applying the biological fluid to the test strip; applying a dose sufficiency test signal having an AC component to at least one of the dose sufficiency electrodes; and measuring a response to the dose sufficiency test signal. - View Dependent Claims (2, 3, 4, 5, 6)
-
-
7. A method of determining a fill sufficiency in test strip for performing a measurement on a biological fluid comprising:
-
providing a biological fluid test strip including; a capillary fill chamber extending a length along the test strip from an intake opening to a terminus, a measurement zone in the chamber positioned intermediate the opening and the terminus, and at least two dose sufficiency electrodes in operative communication with the chamber the electrodes positioned intermediate the measurement zone and the terminus; introducing the biological fluid to the opening effective to cause the fluid to flow toward the terminus whereby the chamber is filled; applying a test signal having an AC component to at least one of the dose sufficiency electrodes; and detecting a response or an absence of the response to the test signal effective to indicate the fill sufficiency of the biological fluid. - View Dependent Claims (8, 9, 10)
-
-
11. A method of determining a dose sufficiency in a test strip for performing a measurement on a biological fluid, comprising:
-
providing a biological fluid test strip comprising; a fluid flow intake opening; a fluid flow terminus; at least two measurement electrodes disposed on the test strip between the opening and the terminus, the measurement electrodes defining a measurement zone; and at least two dose sufficiency electrodes defining a gap therebetween and located between the measurement zone and the terminus; applying the biological fluid to the test strip; applying a dose sufficiency test signal having an AC component to at least one of the dose sufficiency electrodes; and measuring a response to the dose sufficiency test signal. - View Dependent Claims (12, 13, 14, 15, 16, 17)
-
-
18. A method of determining a fill sufficiency in test strip for performing a measurement on a biological fluid comprising:
-
providing a biological fluid test strip, comprising; a fluid flow intake opening; a fluid flow terminus; a measurement zone positioned intermediate the opening and the terminus, and at least two dose sufficiency electrodes positioned intermediate the measurement zone and the terminus; introducing the biological fluid to the opening effective to cause the fluid to flow toward the terminus; applying a test signal having an AC component to at least one of the dose sufficiency electrodes; and detecting a response or an absence of the response to the test signal effective to indicate a volume sufficiency of the biological fluid. - View Dependent Claims (19, 20, 21, 22)
-
-
23. A method of determining dosage fill level in a test strip for performing a measurement on a biological fluid comprising:
-
providing a biological fluid test strip including; a capillary fill chamber extending a length along the test strip from an opening to a terminus, and at least two dose sufficiency electrodes in operative communication with the chamber the dose sufficiency electrodes positioned to define a gap between one another; dosing the test strip with a biological fluid effective to cause the biological fluid to begin to fill the chamber; applying a test signal having an AC component to at least one of the dose sufficiency electrodes; measuring a response to the test signal; determining the dosage fill level based upon the response. - View Dependent Claims (24, 25, 26, 27)
-
-
28. A method of determining a fill level of a biological fluid in a test strip for performing a measurement on the fluid comprising:
-
providing a test strip including a capillary fill chamber extending a length along the test strip from an opening to a terminus, and at least two dose sufficiency electrodes in operative communication with the chamber the dose sufficiency electrodes positioned to define a gap between one another; introducing the biological fluid to the opening effective to cause the fluid to flow toward the terminus whereby the chamber is filled; applying a test signal having an AC component to at least one of the dose sufficiency electrodes; and measuring a response to the test signal; determining the fill level of the biological fluid based upon the response wherein the response varies in relation to the fill level. - View Dependent Claims (29, 30, 31)
-
-
32. A system for performing a measurement on a biological fluid, the system comprising:
-
a test strip comprising; a capillary fill chamber extending a length along the test strip from an opening to a terminus; at least two measurement electrodes in operative communication with the chamber; and at least two dose sufficiency electrodes in operative communication with the chamber; wherein the dose sufficiency electrodes have first edges substantially parallel to the length of the capillary chamber and second edges substantially perpendicular to the length of the capillary fill chamber with the first edges being of greater length than the second edges; and a signal generator operable to apply a signal having an AC component to at least one of the dose sufficiency electrodes. - View Dependent Claims (33)
-
-
34. A system for performing a measurement on a biological fluid, the system comprising:
-
a test strip comprising; a capillary fill chamber extending a length along the test strip from an opening to a terminus; a measurement zone in the chamber positioned intermediate the opening and the terminus, and at least two dose sufficiency electrodes in operative communication with the chamber the electrodes positioned intermediate the measurement zone and the terminus; wherein the dose sufficiency electrodes have a first axis substantially parallel to the length of the capillary chamber and a second axis substantially perpendicular to the length of the capillary fill chamber with the first axis being of greater length than the second axis; and a signal generator operable to apply a signal having an AC component to at least one of the dose sufficiency electrodes. - View Dependent Claims (35)
-
-
36. A system for performing a measurement on a biological fluid, the system comprising:
-
a test strip comprising; a fluid flow path extending a length along the test strip from an opening to a terminus; at least two measurement electrodes in operative communication with the fluid flow path; and at least two dose sufficiency electrodes in operative communication with the fluid flow path; wherein the dose sufficiency electrodes have first edges substantially parallel to the length of the fluid flow path and second edges substantially perpendicular to the length of the fluid flow path with the first edges being of greater length than the second edges; and a signal generator operable to apply a signal having an AC component to at least one of the dose sufficiency electrodes. - View Dependent Claims (37, 38)
-
-
39. A system for performing a measurement on a biological fluid, the system comprising:
-
a test strip comprising; a fluid flow path extending a length along the test strip from an opening to a terminus; a measurement zone in the chamber positioned intermediate the opening and the terminus, and at least two dose sufficiency electrodes in operative communication with the fluid flow path, the electrodes positioned intermediate the measurement zone and the terminus; wherein the dose sufficiency electrodes have a first axis substantially parallel to the length of the fluid flow path and a second axis substantially perpendicular to the length of the fluid flow path with the first axis being of greater length than the second axis; and a signal generator operable to apply a signal having an AC component to at least one of the dose sufficiency electrodes. - View Dependent Claims (40, 41)
-
-
42. A method for performing a measurement on a biological fluid, the method comprising the steps of:
-
a) providing a test strip comprising; a capillary fill chamber extending a length along the test strip from an opening to a terminus; at least two measurement electrodes in operative communication with the chamber; and at least two dose sufficiency electrodes in operative communication with the chamber; wherein the dose sufficiency electrodes have first edges substantially parallel to the length of the capillary chamber and second edges substantially perpendicular to the length of the capillary fill chamber with the first edges being of greater length than the second edges; and b) applying a signal having an AC component to at least one of the dose sufficiency electrodes. - View Dependent Claims (43)
-
-
44. A method for performing a measurement on a biological fluid, the method comprising the steps of:
-
a) providing a test strip comprising; a capillary fill chamber extending a length along the test strip from an opening to a terminus; a measurement zone in the chamber positioned intermediate the opening and the terminus, and at least two dose sufficiency electrodes in operative communication with the chamber the electrodes positioned intermediate the measurement zone and the terminus; wherein the dose sufficiency electrodes have a first axis substantially parallel to the length of the capillary chamber and a second axis substantially perpendicular to the length of the capillary fill chamber with the first axis being of greater length than the second axis; and b) applying a signal having an AC component to at least one of the dose sufficiency electrodes. - View Dependent Claims (45)
-
-
46. A method for performing a measurement on a biological fluid, the method comprising the steps of:
-
a) providing a test strip comprising; a fluid flow path extending a length along the test strip from an opening to a terminus; at least two measurement electrodes in operative communication with the fluid flow path; and at least two dose sufficiency electrodes in operative communication with the fluid flow path; wherein the dose sufficiency electrodes have first edges substantially parallel to the length of the fluid flow path and second edges substantially perpendicular to the length of the fluid flow path with the first edges being of greater length than the second edges; and b) applying a signal having an AC component to at least one of the dose sufficiency electrodes. - View Dependent Claims (47, 48)
-
-
49. A method for performing a measurement on a biological fluid, the method comprising the steps of:
-
a) providing a test strip comprising; a fluid flow path extending a length along the test strip from an opening to a terminus; a measurement zone in the chamber positioned intermediate the opening and the terminus, and at least two dose sufficiency electrodes in operative communication with the fluid flow path, the electrodes positioned intermediate the measurement zone and the terminus; wherein the dose sufficiency electrodes have a first axis substantially parallel to the length of the fluid flow path and a second axis substantially perpendicular to the length of the fluid flow path with the first axis being of greater length than the second axis; and b) applying a signal having an AC component to at least one of the dose sufficiency electrodes. - View Dependent Claims (50, 51)
-
-
52. A system for performing a measurement on a biological fluid, the system comprising:
-
a test strip comprising; a capillary fill chamber extending a length along the test strip from an opening to a terminus; at least two measurement electrodes in operative communication with the chamber; and at least two dose sufficiency electrodes in operative communication with the chamber; wherein the dose sufficiency electrodes have first edges substantially parallel to the length of the capillary chamber and second edges substantially perpendicular to the length of the capillary fill chamber with the first edges being of greater length than the second edges; and a circuit operable to; a) apply a signal to at least one of the dose sufficiency electrodes; b) measure a response to the signal; and c) compare the response to a predetermined threshold to indicate whether the biological fluid substantially fills the capillary fill chamber, wherein the threshold is configured and adapted to prevent false indications of the biological fluid substantially filling the capillary fill chamber. - View Dependent Claims (53)
-
-
54. A system for performing a measurement on a biological fluid, the system comprising:
-
a test strip comprising; a capillary fill chamber extending a length along the test strip from an opening to a terminus; a measurement zone in the chamber positioned intermediate the opening and the terminus, and at least two dose sufficiency electrodes in operative communication with the chamber the electrodes positioned intermediate the measurement zone and the terminus; wherein the dose sufficiency electrodes have a first axis substantially parallel to the length of the capillary chamber and a second axis substantially perpendicular to the length of the capillary fill chamber with the first axis being of greater length than the second axis; and a circuit operable to; a) apply a signal to at least one of the dose sufficiency electrodes; b) measure a response to said signal; and c) compare the response to a predetermined threshold to indicate whether the biological fluid substantially fills the measurement zone, wherein the threshold is configured and adapted to prevent false indications of the biological fluid substantially filling the measurement zone. - View Dependent Claims (55)
-
-
56. A system for performing a measurement on a biological fluid, the system comprising:
-
a test strip comprising; a fluid flow path extending a length along the test strip from an opening to a terminus; at least two measurement electrodes in operative communication with the fluid flow path; and at least two dose sufficiency electrodes in operative communication with the fluid flow path; wherein the dose sufficiency electrodes have first edges substantially parallel to the length of the fluid flow path and second edges substantially perpendicular to the length of the fluid flow path with the first edges being of greater length than the second edges; and a circuit operable to; a) apply a signal to at least one of the dose sufficiency electrodes; b) measure a response to the signal; and c) compare the response to a predetermined threshold to indicate whether the biological fluid substantially fills the fluid flow path, wherein the threshold is configured and adapted to prevent false indications of the biological fluid substantially filling the fluid flow path. - View Dependent Claims (57, 58)
-
-
59. A system for performing a measurement on a biological fluid, the system comprising:
-
a test strip comprising; a fluid flow path extending a length along the test strip from an opening to a terminus; a measurement zone in the chamber positioned intermediate the opening and the terminus, and at least two dose sufficiency electrodes in operative communication with the fluid flow path, the electrodes positioned intermediate the measurement zone and the terminus; wherein the dose sufficiency electrodes have a first axis substantially parallel to the length of the fluid flow path and a second axis substantially perpendicular to the length of the fluid flow path with the first axis being of greater length than the second axis; and a circuit operable to; a) apply a signal to at least one of the dose sufficiency electrodes; b) measure a response to said signal; and c) compare the response to a predetermined threshold to indicate whether the biological fluid substantially fills the measurement zone, wherein the threshold is configured and adapted to prevent false indications of the biological fluid substantially filling the measurement zone. - View Dependent Claims (60, 61)
-
-
62. A method of determining dose sufficiency in a test strip for performing a measurement on a biological fluid comprising:
-
providing a biological fluid test strip, comprising; a capillary fill chamber extending a length along the test strip from an intake opening to a terminus, at least two measurement electrodes disposed in the capillary fill chamber between the opening and the terminus, the measurement electrodes defining a measurement zone, and at least two dose sufficiency electrodes defining a gap therebetween and in operative communication with the capillary fill chamber, the electrodes located between the measurement zone and the terminus; applying the biological fluid to the opening, whereby the fluid flows from the opening toward the terminus, the flow including a flow front selected from one of a concave, a convex and a substantially flat flow front; applying a test signal to at least one of the dose sufficiency electrodes; determining the presence or absence of a response to the test signal above a predetermined threshold, wherein the predetermined threshold is set to indicate whether the biological fluid substantially fills the measurement zone, wherein the threshold is configured and adapted to prevent false indications of the biological fluid substantially filling the measurement zone. - View Dependent Claims (63, 64, 65)
-
-
66. A method of determining dose sufficiency in a test strip for performing a measurement on a biological fluid comprising:
-
providing a biological fluid test strip, comprising; a fluid flow intake opening, a fluid flow terminus, at least two measurement electrodes disposed on the test strip between the opening and the terminus, the measurement electrodes defining a measurement zone, and at least two dose sufficiency electrodes defining a gap therebetween and located between the measurement zone and the terminus; applying the biological fluid to the opening, whereby the fluid flows from the opening toward the terminus, the flow including a flow front selected from one of a concave, a convex and a substantially flat flow front; applying a test signal to at least one of the dose sufficiency electrodes; determining the presence or absence of a response to the test signal above a predetermined threshold, wherein the predetermined threshold is set to indicate whether the biological fluid substantially fills the measurement zone, wherein the threshold is configured and adapted to prevent false indications of the biological fluid substantially filling the measurement zone. - View Dependent Claims (67, 68, 69, 70)
-
Specification