COMBINATIONS FOR THE TREATMENT OF B-CELL PROLIFERATIVE DISORDERS
First Claim
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1. A method of treating a B-cell proliferative disorder, said method comprising administering to a patient a combination of an A2A receptor agonist and a PDE inhibitor in amounts that together are effective to treat said B-cell proliferative disorder.
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Abstract
The invention features compositions and methods employing combinations of an A2A receptor agonist and a PDE inhibitor for the treatment of a B-cell proliferative disorder, e.g., multiple myeloma.
42 Citations
34 Claims
- 1. A method of treating a B-cell proliferative disorder, said method comprising administering to a patient a combination of an A2A receptor agonist and a PDE inhibitor in amounts that together are effective to treat said B-cell proliferative disorder.
- 18. A kit comprising (i) a PDE inhibitor and (ii) an A2A receptor agonist in an amount effective to treat a B-cell proliferative disorder.
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19. A kit comprising (i) an A2A receptor agonist and (ii) a PDE inhibitor having activity against at least two of PDE 2, 3, 4, and 7.
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20. A kit comprising (i) an A2A receptor agonist and (ii) two or more PDE inhibitors that when combined have activity against at least two of PDE 2, 3, 4, and 7.
- 21. A kit comprising (i) an A2A receptor agonist, (ii) a PDE inhibitor, and (iii) an antiproliferative compound.
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26. A pharmaceutical composition comprising (i) a PDE inhibitor and (ii) an A2A receptor agonist in an amount effective to treat a B-cell proliferative disorder and (iii) a pharmaceutically acceptable carrier.
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27. A pharmaceutical composition comprising (i) an A2A receptor agonist and (ii) a PDE inhibitor having activity against at least two of PDE 2, 3, 4, and 7 and (iii) a pharmaceutically acceptable carrier.
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28. A pharmaceutical composition comprising (i) an A2A receptor agonist and (ii) two or more PDE inhibitors that when combined have activity against at least two of PDE 2, 3, 4, and 7 and (iii) a pharmaceutically acceptable carrier.
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29. A kit comprising:
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(i) a composition comprising an A2A receptor agonist and a PDE inhibitor; and (ii) instructions for administering said composition to a patient for the treatment of a B-cell proliferative disorder. - View Dependent Claims (33)
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30. A kit comprising:
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(i) an A2A receptor agonist; and (ii) instructions for administering said A2A receptor agonist with a PDE inhibitor to a patient for the treatment of a B-cell proliferative disorder.
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31. A kit comprising:
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(i) a PDE inhibitor; and (ii) instructions for administering said PDE inhibitor with an A2A receptor agonist to a patient for the treatment of a B-cell proliferative disorder.
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32. A kit comprising:
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(i) a PDE inhibitor; (ii) an A2A receptor agonist; and (iii) instructions for administering said PDE inhibitor and said A2A receptor agonist to a patient for the treatment of a B-cell proliferative disorder.
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34. A kit comprising:
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(i) two or more PDE inhibitors that when combined have activity against at least two of PDE2, 3, 4, and 7; (ii) an A2A receptor agonist; and (iii) instructions for administering said two or more PDE inhibitors and said A2A receptor agonist to a patient for the treatment of a B-cell proliferative disorder.
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Specification