Scaffold-organized clusters and electronic devices made using such clusters

• US 20090047753A1
• Filed: 07/25/2008
• Published: 02/19/2009
• Est. Priority Date: 03/24/2000
• Status: Abandoned Application

• Current Assignee: Oregon State University (Oregon University System)
• Original Assignee: Oregon State University (Oregon University System), University of Oregon
• Inventors: Reed, Scott M., Hutchison, James E., Wybourne, Martin N.
• Application Number:
  US12/220,580
• Publication Number:
  US 20090047753A1
• Time in Patent Office: Days
• US Class Current: 438/99
• CPC Class Codes: B82Y 10/00 Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: G01N 33/54353 with ligand attached to the carrier via a chemical coupling agent coatings G01N33/54393
• CPC Class Codes: H10K 10/701 Organic molecular electronic devices
• CPC Class Codes: H10K 85/761 Biomolecules or bio-macromolecules, e.g. proteins, chlorophyl, lipids or enzymes

Abstract

A method for forming arrays of metal, alloy, semiconductor or magnetic clusters is described. The method comprises placing a scaffold on a substrate, the scaffold comprising, for example, polynucleotides and/or polypeptides, and coupling the clusters to the scaffold. Methods of producing arrays in predetermined patterns and electronic devices that incorporate such patterned arrays are also described.

Claims

1. A method for forming arrays of metal, alloy, semiconductor and/or magnetic clusters, comprising:

placing a scaffold on a substrate; and

coupling monodispersed clusters, selected from the group consisting of metal clusters, alloy clusters, semiconductor clusters, magnetic clusters, and combinations thereof, to the scaffold.

2. The method of claim 1, wherein coupling comprises contacting the scaffold with clusters having plural exchangeable ligands, where at least one of the ligands is exchanged for a functional group of the scaffold.

3. The method of claim 1, wherein coupling comprises contacting the scaffold with clusters having plural ligands, where at least one of the ligands is charged and is electrostatically attracted to a scaffold of opposite charge.

4. The method of claim 3, wherein the scaffold is positively charged polylysine and the plural ligands of the clusters include at least one having a negatively charged group.

5. The method of claim 4, wherein the negatively charged group is selected from the group consisting of carboxylate, sulfonate, and combinations thereof.

6. The method of claim 4, wherein the polylysine is poly-L-lysine.

7. The method of claim 3, wherein the scaffold is a polynucleotide having a negatively charged phosphate backbone and the plural ligands of the clusters include at least one having a positively charged group selected from the group consisting of protonated amine groups, quaternary ammonium groups, and combinations thereof.

8. The method of claim 1, wherein coupling comprises contacting the scaffold with clusters having plural ligands, where at least one of the ligands becomes associated with the scaffold through a hydrophobic interaction.

9. The method of claim 8, wherein the scaffold is a polynucleotide and the plural ligands of the clusters include at least one ligand that intercalates into the polynucleotide.

10. The method of claim 9, wherein the polynucleotide is DNA.

11. The method of claim 1, wherein placing the scaffold on the substrate comprises placing the scaffold on the substrate in a predetermined pattern.

12. The method of claim 11, wherein placing the scaffold on the substrate in a predetermined pattern comprises aligning the scaffold in an electric field created between electrodes on the substrate.

13. The method of claim 12, wherein the scaffold has an electric dipole moment that causes the scaffold to align in the electric field.

14. The method of claim 13, wherein the scaffold is a helical polynucleotide.

15. The method of claim 13, wherein the scaffold is a helical polypeptide.

16. The method of claim 15, wherein the helical polypeptide is in the form of an α

-helix.

17. The method of claim 16, wherein the polypeptide is polylysine.

18. The method of claim 11, wherein placing the scaffold on the substrate in a predetermined pattern comprises polymerizing monomers, oligomers, or polypeptides into larger polypeptides to form a scaffold between two electrodes on the surface of the substrate.

19. The method of claim 11, wherein placing the scaffold on the substrate in a predetermined pattern comprises anchoring the scaffold and inducing alignment of the anchored scaffold in a particular direction by fluid flow.

20. The method of claim 19, wherein the scaffold is attached to a first electrode and aligned by fluid flow, substantially in the direction of a second electrode.