Membrane Active Heteropolymers
First Claim
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1. A membrane active heteropolymer having the general structure comprising:
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-(A)-(B)-(C)-wherein, A contains a pendent cationic functional group, B contains a first hydrophobic pendant group and C contains a second hydrophobic pendent group and B and C are different.
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Abstract
The present invention is directed to a class of membrane active polymers useful for cellular delivery of compounds. Conjugation of the described membrane active polymers to targeting, anti-opsonization, and anti-aggregation agents provides polymers suitable for in vivo delivery. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
41 Citations
26 Claims
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1. A membrane active heteropolymer having the general structure comprising:
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-(A)-(B)-(C)-wherein, A contains a pendent cationic functional group, B contains a first hydrophobic pendant group and C contains a second hydrophobic pendent group and B and C are different. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification