Broadband illuminator for oximetry, hemoglobin, met-hemoglobin, carboxy-hemoglobin, and other blood component monitoring

• US 20090048502A1
• Filed: 05/01/2008
• Published: 02/19/2009
• Est. Priority Date: 04/09/2002
• Status: Abandoned Application

• Current Assignee: JB IP Acquisitions LLC
• Original Assignee: JB IP Acquisitions LLC
• Inventors: Fierro, Michael R., Benaron, David A., Parachikov, Illian H.
• Application Number:
  US12/113,887
• Publication Number:
  US 20090048502A1
• Time in Patent Office: Days
• US Class Current: 600/328
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/14551 for measuring blood gases

Abstract

An ischemia detection system in two or more somatic measures, collected simultaneously or near-simultaneously, are provided for direct or computational comparison, in which light from light source A (103A) and source B (103B) is detected by a sensor (155), and a difference-weighted value is determined (167), thereby enhancing the value of the spectroscopic measurements over values taken individually and singly.

Claims

1-23. -23. (canceled)

24. A broadband method of spectroscopic monitoring in vivo comprising the steps of:

(a) placing an oximeter probe on, in or near a tissue site;

(b) illuminating the tissue site with broadband illumination from a broadband solid-state illumination source having a usable spectral bandwidth of at least 100 nm;

(c) monitoring broadband light returning from a monitored site; and

,

(d) determining a measure of hemoglobin oxygenation or other hemoglobin, tissue, or blood measures based upon said broadband light.

25. The method of claim 24 wherein said tissue site is selected from the list of tissue sites consisting of oropharynx, nasopharynx, esophagus, stomach, duodenum, ileum, colon, skin, and other tissue sites.

26. The method of claim 24 wherein said probe is selected from the list of probes consisting of probes for medical endoscopic use, targetable injection needles, catheters, needles, catheters with extendable needles, nibblers, devices with jaws, scissors, probes that measure colon oxygenation, probes that measure by pulse oximetry, probes that measure arterial oxygenation, probes that measure oxygen delivery to the body'"'"'s core organs, probes that measure in the gastrointestinal system at or in the oropharynx, nasopharynx, esophagus, stomach, duodenum, ileum, colon, or other gastrointestinal tissues.

29. The method of claim 24 wherein said step of determining comprises determining an oxygenation index over time during a medical intervention, wherein said intervention is further modified based upon the result of said step of determining.

30. The method of claim 29 wherein said medical intervention is a vascular procedure directed toward a coronary blood vessel, an arterial blood supply, or other blood vessels, said tissue site is the gastrointestinal mucosa, and said oxygenation index is a measure of ischemia.

31. The method of claim 29 wherein said medical intervention is a vascular tie off or other vascular procedure during which the local blood flow may change.

37. The method of claim 24, 27 or 36 wherein the broadband illumination source is a broadband LED.

38. The method of claim 37 wherein the broadband LED is a white LED

39. The method of claim 37 wherein the broadband LED is comprised of multiple discrete LEDs.

40. The method of claim 39 wherein the multiple LEDs operate in at least one wavelength band.

41. The method of claim 37 wherein the broadband illumination source is comprised to multiple light emitting elements, such as a combination of different light emitting diodes, to produce a spectrum of light.

42. The method of claim 24 or 27 wherein the step of monitoring includes the step of monitoring an AC component of broadband light returning from a monitored tissue site;

and wherein the step of determining includes the step of determining a pulse oximetry hemoglobin saturation or a measure of met-hemoglobin, carboxy-hemoglobin or other blood components, based at least in part upon said AC component of the returning light.

44. The method of claim 37 wherein the broadband LED contains a blue LED and a phosphor.

45. The method of claim 37, wherein the broadband LED contains an LED a fluorescent dye.

27. A broadband method of spectroscopic monitoring in vivo comprising the steps of:

(a) illuminating a tissue site with a broadband solid-state illumination source having at least a visible light portion with some wavelengths shorter than 700 nm;

(b) monitoring at least a portion of the broadband light returning from the tissue site; and

,

(c) determining an index of hemoglobin or other blood components based upon said returning light.

28. The method of claim 27 wherein said visible portion of broadband illumination comprises a portion of the visible spectral band from 500 nm to 600 nm.

43. The method of claim 27 wherein said broadband source emits useable light over a wavelength range of at least 100 nm or more.

32. A broadband optical spectroscopy system comprising:

(a) a broadband, solid-state illumination source for illuminating a target region having at least a visible light portion with at least some wavelengths shorter than 700 nm;

(b) an optical collector for collecting broadband light returning from said target region and for transmitting a collected signal to a spectroscopic monitor; and

(c) oximetry monitoring means for receiving and analyzing collected broadband light as a function of wavelength, said receiving and analyzing including at least a portion of received visible light, and for determining an oxygen saturation index of hemoglobin in said target region based upon said monitored visible light.

34. The oximeter system of claim 32 or 33 wherein said saturation or index determination is performed at least in part using collected light in at least a portion of the visible violet to green spectrum from 400 to 600 nm.

35. The oximeter system of claim 32 or 33 wherein said saturation or index determination is performed at least in part using collected light in at least a portion of the green to orange spectral band from 500 to 600 nm.

50. The system of claim 32, 33, or 36 wherein said system is selected from the group of systems consisting of spectrophotometers, oximeters, systems that perform pulse oximetry, microdevices, a microchip, a lab-on-a-chip, or other small optical device with space and size constraints, disposable optical devices, or other optical spectroscopy devices and systems.

52. The system of claim 32 or 33, wherein the system is a medical device configured for use in oximetry.

53. The system of claim 52 wherein the system is medical device is an oximeter probe.

54. The system of claim 52 wherein the system is a medical device configured for use in monitoring met-hemoglobin, carboxy-hemoglobin, and other blood components.

57. The system of claim 52 wherein the broadband source is incorporated into a pulse oximeter.

58. The system of claim 32 or 33 wherein the monitoring comprises monitoring an AC component of broadband light returning from a monitored tissue site;

and wherein the determining comprises determining a pulse oximetry hemoglobin saturation or a measure of met-hemoglobin, carboxy-hemoglobin or other blood components, based at least in part upon said AC component of the returning light.

33. A broadband optical spectroscopy system comprising:

(a) a broadband, solid-state illumination source, said source having a usable spectral bandwidth of at least 100 nm for illuminating a target region;

(b) an optical collector for collecting broadband light returning from said target region and for transmitting a collected signal to a spectroscopic monitor; and

,

(c) spectroscopic monitoring means for receiving and analyzing collected broadband light, and for determining an index or measure of hemoglobin or other blood components in said target region based upon said monitored light.

51. The system of claim 33 or 36 wherein the system is a medical device selected from the group of devices consisting of probes for medical endoscopic use, targetable injection needles, catheters, needles, catheters with extendable needles, nibblers, devices with jaws, scissors, probes that measure colon oxygenation, probes that measure by pulse oximetry, probes that measure arterial oxygenation, probes that measure oxygen delivery to the body'"'"'s core organs, probes that measure in the gastrointestinal system including could reasonably include the oropharynx, nasopharynx, esophagus, stomach, duodenum, ileum, colon, or other gastrointestinal tissues.

36. A broadband spectroscopy method for monitoring in vivo comprising the steps of:

(a) illuminating a tissue with a broadband solid-state illumination source having a usable spectral bandwidth of at least 100 nm;

(b) monitoring broadband light returning from a monitored site, wherein the monitoring includes the step of monitoring an AC component of broadband light returning from a monitored tissue site; and

,

(c) determining a pulse oximetry hemoglobin oxygenation index, or a measure of met-hemoglobin, carboxy-hemoglobin or other blood components, based upon said monitoring, where the step of determining is based at least in part upon said AC component of the returning light.

46. The method of claim 36 wherein the broadband source operates to produce at least a portion of its illumination in the infrared spectrum.

47. The method of claim 36 wherein the broadband source operates to produce at least a portion of its illumination in the ultraviolet spectrum.

48. The method of claim 36 wherein a target signal is enhanced, produced, or detected, at least in part, by one or more of the following methods:

light absorbance, polarization, optical rotation, scattering, fluorescence, Raman effects, phosphorescence, fluorescence decay, re-emission, use of a contrast agent, dye-shift, or other known spectroscopy techniques.

49. The method of claim 36 wherein said determining involves a solution of multiple simultaneous spectroscopic equations.

55. The method of claim 36 wherein the broadband source light is pulsed.

56. The method of claim 36, wherein the broadband source light is analyzed as time-resolved, frequency-resolved, or spatially-resolved.