Lubricious coatings

• US 20090048537A1
• Filed: 01/31/2007
• Published: 02/19/2009
• Est. Priority Date: 01/31/2006
• Status: Abandoned Application

• Current Assignee: Angiotech Pharmaceuticals Incorporated
• Original Assignee: Angiotech Pharmaceuticals Incorporated
• Inventors: Kozlowski, Martin Jay, Lydon, Margaret, Jackson, Kristy, Copenhagen, Donald M., Avelar, Rui, Whitbourne, Richard J.
• Application Number:
  US12/162,556
• Publication Number:
  US 20090048537A1
• Time in Patent Office: Days
• US Class Current: 600/585
• CPC Class Codes: A61L 29/041 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 29/14 Materials characterised by their function or physical properties , e.g. lubricating compositions
• CPC Class Codes: C08L 33/08 Homopolymers or copolymers of acrylic acid esters

Abstract

Medical devices can include a lubricious coating that is slippery when wet.

Claims

1. A medical device comprising a surface coated with a first layer proximal to the surface, the first layer including an ethylene/acrylic acid copolymer.

2. The device of claim 1, wherein the first layer further includes an epoxy resin.

3. The device of claim 1, wherein the device is a blade device.

4. The device of claim 1, further comprising a second layer coated on the first layer, the second layer including an aromatic polycarbonate based polyurethane.

5. The device of claim 4, wherein the second layer further includes a cellulose based polymer.

6. The device of claim 4, further comprising a third layer coated on the second layer, the third layer including a polyvinyl pyrrolidone.

7. The device of claim 6, wherein the third layer further includes a cellulose based polymer.

8. The device of claim 7, wherein the first layer is coated on the surface by dip-coating with a solution comprising the ethylene/acrylic acid copolymer, an epoxy resin, tetrahydrofuran, dimethyl acetamide, anisole, and xylenes, and drying.

9. The device of claim 8, wherein the second layer is coated on the first layer by dip-coating with a solution comprising an aromatic polycarbonate based polyurethane, a nitrocellulose, dimethylacetamide, anisole, methyl ethyl ketone, and n-butanol, and drying.

10. The device of claim 9, wherein the third layer is coated on the second layer by dip-coating with a solution comprising a polyvinylpyrrolidone, a nitrocellulose, 4-butyrolactone, ethanol, benzyl alcohol, cyclohexanone, and isopropanol, and drying.

11. A medical device comprising a surface coated with a first layer proximal to the surface, the first layer including a cellulose based polymer, a urethane, a melamine resin, and a cross-linkable acrylic resin.

12. The device of claim 11, wherein the device is a guidewire.

13. The device of claim 11, further comprising a second layer coated on the first layer, the second layer including a nitrocellulose, a polyvinylpyrollidone, and a plasticizer.

14. The device of claim 13, wherein the plasticizer is a poly(alkylene oxide).

15. The device of claim 14, wherein the urethane is Tycel 7000, the melamine resin is Cymel 248-8, and the cross-linkable acrylic resin is Paraloid AT-746.

16. The device of claim 15, wherein the polyvinylpyrollidone is PVP K90, and the poly(alkylene oxide) is a polyethylene glycol 400.

17. A medical device comprising a surface coated with a first layer proximal to the surface, the first layer being coated on the surface by contacting the surface with a solution comprising ethanol, benzyl alcohol, cyclohexanone, tetrahydrofuran, a nitrocellulose, 4-butyrlactone, and a polyvinylpyrrolidone, and drying.

18. The device of claim 17, wherein the device is a catheter.

19. The device of claim 18, wherein the surface is a thermoplastic polyurethane elastomer.

20. The device of claim 19, wherein the thermoplastic polyurethane elastomer is a pellethane.

21. A medical device comprising a surface coating bonded to a surface of the device, wherein the coating swells when exposed to body fluids;

wherein the coating provides a substantial reduction in surface friction after swelling.

22. The medical device of claim 21, wherein the coating comprises multiple layers.

23. The medical device of claim 21, wherein the coating comprises a polyvinylpyrrolidone, a polyvinylpyrrolidone/vinyl acetate copolymer, and a polyethylene glycol.

24. The medical device of claim 23, wherein the coating further comprises a cellulose ester, a polyvinyl chloride, an acrylic polymer or copolymer, a polyurethane, a polyamide polymer, a polyimide polymer, or an epoxy resin.

25. The medical device of claim 23, wherein the polyvinylpyrrolidone has a molecular weight of at least 80 kDa.

26. The medical device of claim 23, wherein the polyvinylpyrrolidone has a molecular weight in the range of 90 kDa to 1,200 kDa.

27. The medical device of claim 23, wherein the cellulose ester is a nitrocellulose.

28. The medical device of claim 23, wherein the device is selected from the group consisting of a catheter, an arterial catheter, a short-term central venous catheter, a long-term central venous catheter, a peripheral venous catheter, a vascular port catheter, a dialysis device, a guide wire, an introducer, a knife, a needle, an amniocentesis needle, a biopsy needle, an infusion needle, an introducer needle, a suture needle, an obdurator, a pacemaker, a pacemaker lead, a penile prosthesis, a scalpel, a shunt, an arteriovenous shunt, a hydrocephalus shunt, a stent, a biliary stent, a coronary stent, a neurological stent, a urological stent, a vascular stent, a syringe, a trocar, a tube, a drain tube, an endotracheal tube, a gastroenteric tube, a nasogastric tube, an intermittent urinary catheter, a Foley catheter, a long-term urinary device, a tissue bonding urinary device, a urinary dilator, a urinary sphincter, a urethral inserts, and a wound drain.

29. The device of claim 21, wherein the surface coating includes a first layer proximal to the device surface, the first layer including an ethylene/acrylic acid copolymer.

30. The device of claim 29, wherein the first layer further includes an epoxy resin.

31. The device of claim 29, wherein the device is selected from the group consisting of a catheter, an arterial catheter, a short-term central venous catheter, a long-term central venous catheter, a peripheral venous catheter, a vascular port catheter, a dialysis device, a guide wire, an introducer, a knife, a needle, an amniocentesis needle, a biopsy needle, an infusion needle, an introducer needle, a suture needle, an obdurator, a pacemaker, a pacemaker lead, a penile prosthesis, a scalpel, a shunt, an arteriovenous shunt, a hydrocephalus shunt, a stent, a biliary stent, a coronary stent, a neurological stent, a urological stent, a vascular stent, a syringe, a trocar, a tube, a drain tube, an endotracheal tube, a gastroenteric tube, a nasogastric tube, an intermittent urinary catheter, a Foley catheter, a long-term urinary device, a tissue bonding urinary device, a urinary dilator, a urinary sphincter, a urethral inserts, and a wound drain.

32. The device of claim 29, wherein the surface of the device comprises a metal or metal alloy.

33. The device of claim 32, wherein the metal or metal alloy is gold, nitinol, nickel, platinum, stainless steel, tantalum, or titanium.

34. The device of claim 21, wherein the surface of the device comprises a polymer or copolymer selected from a silicone, a polyethylene, a polypropylene, a polyester, a polytetrafluoroethylene, a polyamide, a polyimide, and a styrene/isobutylene copolymer.

35. The device of claim 29, further comprising a second layer coated on the first layer, the second layer comprising a polyurethane, a poly(vinyl chloride), a polyamide, an acrylate polymer or copolymer, a polyimide, a polyester, a polycarbonate urethane, an aliphatic urethane, an aromatic urethane, or a cellulose ester.

36. The device of claim 29, further comprising a third layer coated on the second layer, the third layer including a polyvinylpyrrolidone, a polyethylene glycol, a polyethylene oxide, or a polyvinylpyrrolidone/vinyl acetate copolymer.

37. The device of claim 36, wherein the third layer further comprises a cellulose ester, a polyamide, an acrylic polymer/copolymer, an epoxy resin, a melamine resin, a formaldehyde resin, a urethane, or a cross-linkable acrylic resin.

38. The device of claim 37, wherein the cellulose ester comprises cellulose nitrate, and the urethane comprises aliphatic urethanes, aromatic urethanes and polycarbonate urethanes.

39. A medical device having a surface coated with a first layer proximal to the surface, the first layer comprising a cellulose ester, a urethane, a melamine resin, a formaldehyde resin, and a cross-linkable acrylic resin.

40. The device of claim 39, further comprising a second layer coated on the first layer, the second layer comprising a nitrocellulose, an aliphatic urethane, an aromatic urethane and a polycarbonate urethane.

41. The device of claim 39, wherein the device is selected from the group consisting of a catheter, an arterial catheter, a short-term central venous catheter, a long-term central venous catheter, a peripheral venous catheter, a vascular port catheter, a dialysis device, a guide wire, an introducer, a knife, a needle, an amniocentesis needle, a biopsy needle, an infusion needle, an introducer needle, a suture needle, an obdurator, a pacemaker, a pacemaker lead, a penile prosthesis, a scalpel, a shunt, an arteriovenous shunt, a hydrocephalus shunt, a stent, a biliary stent, a coronary stent, a neurological stent, a urological stent, a vascular stent, a syringe, a trocar, a tube, a drain tube, an endotracheal tube, a gastroenteric tube, a nasogastric tube, an intermittent urinary catheter, a Foley catheter, a long-term urinary device, a tissue bonding urinary device, a urinary dilator, a urinary sphincter, a urethral inserts, and a wound drain.

42. The device of claim 39, wherein the surface comprises a metal or a metal alloy.

43. The device of claim 42, wherein the metal or metal alloy is gold, nitinol, nickel, platinum, stainless steel, tantalum, or titanium.

44. A method of making a medical device, comprising forming a first layer on a surface of the device, the first layer including an ethylene/acrylic acid copolymer.

45. The method of claim 44, further comprising forming a second layer on the first layer, the second layer including an aromatic polycarbonate based polyurethane.

46. The method of claim 45, further comprising forming a third layer on the second layer, the third layer including a polyvinyl pyrrolidone.

47. The method of claim 44, wherein forming the first layer includes contacting the surface of the device with a solution comprising the ethylene/acrylic acid copolymer, an epoxy resin, tetrahydrofuran, dimethyl acetamide, anisole, and xylenes, and drying.

48. The method of claim 44, wherein forming the second layer includes contacting the first layer with a solution comprising an aromatic polycarbonate based polyurethane, a nitrocellulose, dimethylacetamide, anisole, methyl ethyl ketone, and n-butanol, and drying.

49. The method of claim 44, wherein forming the third layer includes contacting the second layer with a solution comprising a polyvinylpyrrolidone, a nitrocellulose, 4-butyrolactone, ethanol, benzyl alcohol, cyclohexanone, and isopropanol, and drying.