IONTOPHORETIC DRUG DELIVERY SYSTEM

• US 20090048556A1
• Filed: 08/15/2008
• Published: 02/19/2009
• Est. Priority Date: 08/17/2007
• Status: Active Grant

• Current Assignee: Isis Biopolymer, LLC
• Original Assignee: Isis Biopolymer, LLC
• Inventors: DURAND, Emma Amelia
• Granted Patent: US 7,945,320 B2
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/7023 Transdermal patches and similar drug-containing composite devices, e.g. cataplasms galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006
• CPC Class Codes: A61N 1/303 Constructional details electrodes for external use A61N1/0428
• CPC Class Codes: H05K 1/095 for polymer thick films, i.e. having a permanent organic polymeric binder
• CPC Class Codes: H05K 1/189 characterised by the use of a flexible or folded printed circuit H05K3/326 takes precedence
• CPC Class Codes: H05K 2201/10037 Printed or non-printed battery
• CPC Class Codes: H05K 3/321 by conductive adhesives

Abstract

The iontophoretic drug delivery system includes electrodes controlled by a microprocessor controller to drive charged molecules contained in a drug reservoir through the skin into the issues of a patient. The iontophoretic drug delivery system further includes an antenna connected to the programmable microprocessor. The antenna allows for the programming of the microprocessor and for the exchange of patient, drug, and treatment related information between the microprocessor and an external device. The iontophoretic drug delivery system is also provided with buttons to allow a patient to manually activate the drug delivery system. The iontophoretic drug delivery system is housed within a thin polyester film membrane.

Claims

1. An iontophoretic drug delivery system for driving charged drug molecules into a tissue, comprising:

a drug reservoir holding the charged drug molecules;

an electrode for driving the charged drug molecules into the tissue;

a microprocessor controller configured to control the electrode;

a wireless signal receiver coupled to the microprocessor controller, whereby the microprocessor controller is programmed by signals sent through the antenna; and

a battery coupled to the microprocessor controller.

2. The system of claim 1, wherein the drug reservoir comprising a gel pad.

3. The system of claim 1, wherein the drug reservoir comprising a membrane.

4. The system of claim 2, wherein the charged drug molecules are carried within the gel pad.

5. The system of claim 3, wherein the charged drug molecules are carried within the membrane.

6. The system of claim 1, wherein the microprocessor controller is connected to the electrodes with flexible printed wires.

7. The drug delivery system of claim 6, wherein the flexible printed wires are made of silver or silver chloride.

8. The drug delivery system of claim 6, wherein said microprocessor controller and electrodes are connected to the flexible printed wires with a conductive cement.

9. An iontophoretic drug delivery system driving charged drug molecules into a tissue, comprising:

a drug reservoir for holding the charged drug molecules;

an electrode for driving the charged drug molecules into the tissue;

a microprocessor controller configured to control the electrode; and

a high-tack adhesive placed around an outer edge of the iontophoretic drug delivery system and a low-tack adhesive placed in a center of the iontophoretic drug delivery system.

10. The system of claim 9, further comprising a wireless signal receiver coupled to the microprocessor controller, whereby the microprocessor controller is programmed by signals sent through the antenna.

11. The system of claim 9, further comprising a battery coupled to the microprocessor controller.

12. The system of claim 9, wherein the drug reservoir comprising a gel pad.

13. The system of claim 9, wherein the drug reservoir comprising a membrane.

14. The system of claim 12, wherein the charged drug molecules are carried within the gel pad.

15. The system of claim 13, wherein the charged drug molecules are carried within the membrane.

16. The system of claim 9, wherein the microprocessor controller is connected to the electrodes with flexible printed wires.

17. The drug delivery system of claim 16, wherein the flexible printed wires are made of silver or silver chloride.

18. The drug delivery system of claim 16, wherein said microprocessor controller and electrodes are connected to the flexible printed wires with a conductive cement.

19. The drug delivery system of claim 9, further comprising a moisture sensor detecting a level of moisture at an interface between said system and a patient'"'"'s skin.

20. An iontophoretic drug delivery system for driving charged drug molecules into a tissue, comprising:

a drug reservoir holding the charged drug molecule;

a tissue permeation enhancer configured to enhance permeation of the drug molecule into the tissue;

an electrode for driving the charged drug molecule into the tissue;

a microprocessor controller configured to control the electrode; and

a battery coupled to the microprocessor controller.

21. A drug delivery system according to claim 20, wherein the permeation enhancer is in the reservoir.

22. A drug delivery system according to claim 21, wherein the permeation enhancer is an excipient.