Spinal Fusion Implants with Selectively Applied Bone Growth Promoting Agent

• US 20090048675A1
• Filed: 08/17/2007
• Published: 02/19/2009
• Est. Priority Date: 04/25/2007
• Status: Abandoned Application

• Current Assignee: Jmea Corporation
• Original Assignee: Jmea Corporation
• Inventors: Yeh, Jack Y., Bhatnagar, Mohit K.
• Application Number:
  US11/840,707
• Publication Number:
  US 20090048675A1
• Time in Patent Office: Days
• US Class Current: 623/17.160
• CPC Class Codes: A61B 17/0642 for bones, e.g. for osteosynthesis or connecting tendon to bone
• CPC Class Codes: A61B 17/70 Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
• CPC Class Codes: A61B 17/7002 Longitudinal elements, e.g. rods
• CPC Class Codes: A61B 17/701 Longitudinal elements with a non-circular, e.g. rectangular, cross-section A61B17/7005, A61B17/7007 take precedence
• CPC Class Codes: A61B 17/7044 also having plates, staples or washers bearing on the vertebrae
• CPC Class Codes: A61B 17/7059 Cortical plates A61B17/7007, A61B17/7058 take precedence
• CPC Class Codes: A61B 17/7064 Devices acting on, attached to, or simulating the effect of, vertebral facets; Tools therefor
• CPC Class Codes: A61B 17/7071 Implants for expanding or repairing the vertebral arch or wedged between laminae or pedicles; Tools therefor
• CPC Class Codes: A61B 17/7208 Flexible pins, e.g. ENDER pins
• CPC Class Codes: A61B 17/7233 with special means of locking the nail to the bone
• CPC Class Codes: A61B 17/7266 with fingers moving radially outwardly
• CPC Class Codes: A61B 17/80 Cortical plates , i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
• CPC Class Codes: A61B 17/809 with bone-penetrating elements, e.g. blades or prongs bone staples A61B17/0642; intramedullary nails with a plate at an end A61B17/7233
• CPC Class Codes: A61B 17/86 Pins or screws or threaded wires; nuts therefor A61B17/72 take precedence
• CPC Class Codes: A61B 17/864 hollow, e.g. with socket or cannulated
• CPC Class Codes: A61B 17/866 Material or manufacture
• CPC Class Codes: A61B 2017/0641 having at least three legs as part of one single body
• CPC Class Codes: A61F 2/30767 Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
• CPC Class Codes: A61F 2/4455 for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages intervertebral discs A61F2/442
• CPC Class Codes: A61F 2/446 having a circular or elliptical cross-section substantially parallel to the axis of the spine, e.g. cylinders or frustocones
• CPC Class Codes: A61F 2/4465 : having a circular or kidney shaped cross-section substantially perpendicular to the axis of the spine
• CPC Class Codes: A61F 2/447 : substantially parallelepipedal, e.g. having a rectangular or trapezoidal cross-section
• CPC Class Codes: A61F 2002/30205 : conical
• CPC Class Codes: A61F 2002/30286 : barrel-shaped
• CPC Class Codes: A61F 2002/30322 : differing in surface structures
• CPC Class Codes: A61F 2002/30448 : using adhesives
• CPC Class Codes: A61F 2002/30593 : hollow
• CPC Class Codes: A61F 2002/30769 : madreporic
• CPC Class Codes: A61F 2002/30772 : Apertures or holes, e.g. of circular cross section
• CPC Class Codes: A61F 2002/30787 : inclined obliquely with respect to each other
• CPC Class Codes: A61F 2002/30841 : Sharp anchoring protrusions for impaction into the bone, e.g. sharp pins, spikes
• CPC Class Codes: A61F 2002/3085 : with a threaded, e.g. self-tapping, bone-engaging surface, e.g. external surface
• CPC Class Codes: A61F 2002/30861 : having threads of increasing or decreasing height
• CPC Class Codes: A61F 2002/30906 : shot- sand- or grit-blasted
• CPC Class Codes: A61F 2002/30909 : Nets
• CPC Class Codes: A61F 2002/30919 : Sleeves
• CPC Class Codes: A61F 2002/3092 : having an open-celled or open-pored structure
• CPC Class Codes: A61F 2002/30925 : etched
• CPC Class Codes: A61F 2002/3093 : for promoting ingrowth of bone tissue
• CPC Class Codes: A61F 2220/005 : using adhesives
• CPC Class Codes: A61F 2230/0063 : Three-dimensional shapes
• CPC Class Codes: A61F 2230/0067 : conical
• CPC Class Codes: A61F 2250/0026 : differing in surface structures
• CPC Class Codes: A61F 2310/00796 : Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
• CPC Class Codes: A61F 2310/00976 : Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF

Abstract

A spinal fusion device including a selectively applied bone growth promoting agent is disclosed. In particular, a bone growth promoting agent is selectively applied to spinal implants, spinal plugs, spinal wedges and other implantable devices.

Claims

1. A spinal fusion device, comprising:

a spinal implant configured for insertion between two vertebrae;

the spinal implant including a first portion and a second portion along an outer surface;

a bone growth promoting agent; and

wherein the bone growth promoting agent is selectively applied to the first portion of the outer surface.

2. The spinal fusion device according to claim 1, wherein the bone growth promoting agent is selectively applied to an inner surface of the spinal implant.

3. The spinal fusion device according to claim 2, wherein the spinal implant includes a plurality of holes.

4. The spinal fusion device according to claim 3, wherein the plurality of holes are disposed on an outer surface of the spinal implant.

5. The spinal fusion device according to claim 3, wherein the plurality of holes includes small holes and large holes.

6. The spinal fusion device according to claim 2, wherein the bone growth promoting agent is selectively applied to at least one of the plurality of holes.

7. The spinal fusion device according to claim 1, wherein the spinal implant has a solid portion.

8. The spinal fusion device according to claim 1, wherein the spinal implant has a hollow portion.

9. The spinal fusion device according to claim 1, wherein the spinal implant has a latticed portion.

10. A spinal fusion device, comprising:

a spinal implant configured for insertion between two vertebrae;

the spinal implant including threading;

the threading including threading peaks and threading valleys;

a bone growth promoting agent; and

wherein the bone growth promoting agent is selectively applied to the threading peaks.

11. The spinal fusion device according to claim 10, wherein the threading peaks include an upper portion, a middle portion and a lower portion.

12. The spinal fusion device according to claim 11, wherein the bone growth promoting agent is selectively applied to a member of the group consisting essentially of the upper portion, the lower portion, the middle portion and the threading valleys.

13. The spinal fusion device according to claim 10, wherein the spinal implant includes a plurality of holes.

14. The spinal fusion device according to claim 13, wherein at least one of the plurality of holes penetrates from an outer surface of the spinal implant to an inner surface associated with a hollow central core.

15. The spinal fusion device according to claim 14, wherein at least one of the plurality of holes has a bottom.

16. A spinal fusion device, comprising:

a spinal plug configured for insertion between two vertebrae;

the spinal plug including a first portion and a second portion along an outer surface;

a bone growth promoting agent; and

wherein the bone growth promoting agent is selectively applied to the first portion of the outer surface.

17. The spinal fusion device according to claim 16, wherein the bone growth promoting agent is selectively applied to a portion of an inner surface of the spinal plug.

18. The spinal fusion device according to claim 16, wherein the spinal plug has a solid portion.

19. The spinal fusion device according to claim 16, wherein the spinal plug has a hollow portion.

20. The spinal fusion device according to claim 16, wherein the spinal plug has a latticed portion.

21. The spinal fusion device according to claim 16, wherein the spinal plug includes a plurality of holes.

22. The spinal fusion device according to claim 21, wherein the bone growth promoting agent is selectively applied to at least one of the holes.

23. The spinal fusion device according to claim 22, wherein the plurality of holes are disposed on a top side and a bottom side of the spinal plug.

24. The spinal fusion device according to claim 23, wherein the plurality of holes includes small holes and large holes.

25. A spinal fusion device, comprising:

a spinal wedge configured for insertion between two vertebrae;

the spinal wedge including a first portion and a second portion along an outer surface;

a bone growth promoting agent; and

wherein the bone growth promoting agent is selectively applied to the first portion of the outer surface.

26. The spinal fusion device according to claim 25, wherein the spinal wedge includes a hollow portion.

27. The spinal fusion device according to claim 25, wherein the spinal wedge includes a solid portion.

28. The spinal fusion device according to claim 25, wherein the spinal wedge includes a latticed portion.

29. The spinal fusion device according to claim 25, wherein the implantable device includes a plurality of holes.

30. The spinal fusion device according to claim 29, wherein the plurality of holes are disposed on a top side and a bottom side of the spinal wedge.

31. The spinal fusion device according to claim 29, wherein the plurality of holes includes small holes and large holes.

32. The spinal fusion device according to claim 29, wherein the bone growth promoting agent is selectively applied to at least one of the plurality of holes.

33. A spinal fusion device, comprising:

an implantable device configured for insertion between two vertebrae;

the implantable device including a first portion and a second portion along an outer surface;

a bone growth promoting agent; and

wherein the bone growth promoting agent is selectively applied to the first portion of the outer surface.

34. The spinal fusion device according to claim 33, wherein the implantable device includes teeth.

35. The spinal fusion device according to claim 33, wherein the implantable device includes a sloped top side.

36. The spinal fusion device according to claim 33, wherein the implantable device includes a sloped bottom side.

37. The spinal fusion device according to claim 36, wherein the implantable device includes a plurality of holes.

38. The spinal fusion device according to claim 37, wherein the plurality of holes are disposed on the sloped top side and the sloped bottom side.

39. The spinal fusion device according to claim 36, wherein the plurality of holes includes small holes and large holes.

40. The spinal fusion device according to claim 37, wherein the bone growth promoting agent is selectively applied to at least one of the plurality of holes.

41. A spinal fusion device, comprising:

an implantable device configured for insertion between two vertebrae;

the implantable device including a first portion and a second portion;

a bone growth promoting agent;

a lattice structure disposed within the implantable device; and

wherein the bone growth promoting agent is selectively applied to the first portion.

42. The spinal fusion device according to claim 41, wherein the first portion includes a portion of a shell of the implantable device.

43. The spinal fusion device according to claim 42, wherein the first portion also includes a portion of the lattice structure, wherein the bone growth promoting agent applied to both the shell and the lattice structure encourages bone growth into the lattice structure and bone integration with the lattice structure.

44. The spinal fusion device according to claim 41, wherein the first portion includes a portion of the lattice structure.

45. The spinal fusion device according to claim 41, wherein the lattice structure is removable from the spinal fusion device.

46. A spinal fusion device, comprising:

an implantable device including a surface associated with a vertebra;

the surface including a hole; and

wherein a bone growth promoting agent is selectively applied to a portion of the hole.

47. The spinal fusion device according to claim 46, wherein the hole extends through the surface.

48. The spinal fusion device according to claim 46, wherein the hole includes a bottom.

49. The spinal fusion device according to claim 46, wherein the hole is microscopic.

50. The spinal fusion device according to claim 46, wherein the hole is macroscopic.

51. A bone fusion device, comprising:

a body portion;

a first inserting portion extending from the body portion;

a second inserting portion extending from the body portion;

wherein the first inserting portion engages a first bone and wherein the second inserting portion engages a second bone; and

wherein a bone growth promoting agent is selectively applied to a portion of the bone fusion device.

52. The bone fusion device according to claim 51, wherein the bone fusion device includes at least one hole, and wherein the hole is microscopic.

53. The bone fusion device according to claim 51, wherein the bone fusion device includes at least one hole, and wherein the hole is macroscopic.

54. The bone fusion device according to claim 51, wherein the first bone is a vertebrae and wherein the second bone is an adjacent vertebrae.

55. The bone fusion device according to claim 51, wherein the bone fusion device includes at least two inserting portions.

56. The bone fusion device according to claim 55, wherein the bone fusion device includes at least four inserting portions.