PREPARATION OF ANTIMICROBIAL CONTACT LENSES WITH REDUCED HAZE USING SWELLING AGENTS

• US 20090051060A1
• Filed: 03/26/2008
• Published: 02/26/2009
• Est. Priority Date: 03/30/2007
• Status: Abandoned Application

• Current Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Inventors: Li, Yongcheng, Beaton, Stephen R.
• Application Number:
  US12/055,654
• Publication Number:
  US 20090051060A1
• Time in Patent Office: Days
• US Class Current: 264/2.600
• CPC Class Codes: A61L 12/088 Heavy metals
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/106 Halogens or compounds thereof, e.g. iodine, chlorite
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

This invention relates to antimicrobial lenses containing metals and methods for their production.

Claims

1. A method of preparing an antimicrobial lens comprising, a metal salt, wherein said method comprises the steps of

(a) treating a cured lens, with a solution comprising salt precursor and a swelling agent,

(b) treating the lens of step (a) with solution comprising a swelling agent for an appropriate period of time, and

(c) treating the lens of step (b) with a solution comprising a metal agent and a swelling agent.

2. The method of claims 1 wherein the swelling agent is selected from the group consisting of extracting solvents as disclosed in U.S. Pat. No. 7,112,652.

3. The method of claim 1 wherein the swelling agent is aqueous isopropanol, or aqueous propylene glycol.

4. The method of claim 1 wherein the swelling agent is about 30% to about 70% aqueous isopropanol.

5. The method of claim 1 wherein the swelling agent is 50% aqueous isopropanol.

6. The method of claim 1 wherein the swelling agent is aqueous propylene glycol.

7. The method of claim 1 wherein the salt precursor is selected from the group consisting sodium chloride, sodium iodide, sodium bromide, sodium sulfide, lithium chloride, lithium iodide, lithium bromide, lithium sulfide, potassium bromide, potassium chloride, potassium sulfide, potassium iodide, rubidium iodide, rubidium bromide, rubidium chloride, rubidium sulfide, caesium iodide, caesium bromide, caesium chloride, caesium sulfide, francium iodide, francium bromide, francium chloride, francium sulfide, and sodium tetrachloro argentate

8. The method of claim 1 wherein the salt precursor is sodium iodide.

9. The method of claim 1 wherein the metal agent is selected from the group consisting of silver nitrate, silver triflate, or silver acetate, silver sulfate, silver tetrafluoroborate, silver sulfate, zinc acetate, zinc sulfate, copper acetate, and copper sulfate.

10. The method of claim 1 wherein the metal agent is silver nitrate.

11. The method of claim 1 wherein the appropriate time is about 10 to about 40 seconds.

12. The method of claim 1 wherein the appropriate time is about 20 to about 30 seconds.

13. The method of claim 1 wherein one or more of the solutions of steps (a), (b), and (c) comprise a dispersing agent.

14. The method of claim 13, wherein the dispersing agent is selected from the group consisting of polyvinylpyrrolidone, polyvinylalcohol and derivatives, glycerine, polyethylene oxide, poly(dimethyl acrylamide), poly(N-vinyl-N-methylacetamide), cysteine, methionine, sodium sulfide, sodium thiosulfate, and sodium thiocyanate.

15. The method of claim 13 wherein the dispersing agent is polyvinylpyrrolidone K90.

16. An antimicrobial lens comprising, a metal salt, made by a method comprise the steps of

(a) treating a cured lens, with a solution comprising salt precursor and a swelling agent,

(b) treating the lens of step (a) with solution comprising a swelling agent for an appropriate time, and

(c) treating the lens of step (b) with a solution comprising a metal agent and a swelling agent.

17. The antimicrobial lens of claim 16 wherein the swelling agent is aqueous isopropanol, or aqueous propylene glycol.

18. The antimicrobial lens of claim 16 wherein the swelling agent is about 30% to about 70% aqueous isopropanol.

19. The antimicrobial lens of claim 16 wherein the swelling agent is 50% aqueous isopropanol.

20. The antimicrobial lens of claim 16 wherein the swelling agent is aqueous propylene glycol.

21. The antimicrobial lens of claim 16 wherein the salt precursor is selected from the group consisting sodium chloride, sodium iodide, sodium bromide, sodium sulfide, lithium chloride, lithium iodide, lithium bromide, lithium sulfide, potassium bromide, potassium chloride, potassium sulfide, potassium iodide, rubidium iodide, rubidium bromide, rubidium chloride, rubidium sulfide, caesium iodide, caesium bromide, caesium chloride, caesium sulfide, francium iodide, francium bromide, francium chloride, francium sulfide, and sodium tetrachloro argentate

22. The antimicrobial lens of claim 16 wherein the salt precursor is sodium iodide.

23. The antimicrobial lens of claim 16 wherein the metal agent is selected from the group consisting of silver nitrate, silver triflate, or silver acetate, silver sulfate, silver tetrafluoroborate, silver sulfate, zinc acetate, zinc sulfate, copper acetate, and copper sulfate.

24. The antimicrobial lens of claim 16 wherein the metal agent is silver nitrate.

25. The antimicrobial lens of claim 16 wherein the appropriate time is about 10 to about 40 seconds.

26. The antimicrobial lens of claim 16 wherein the appropriate time is about 20 to about 30 seconds.

27. The antimicrobial lens of claim 16 wherein one or more of the solutions of steps (a), (b), and (c) comprise a dispersing agent.

28. The antimicrobial lens of claim 16, wherein the dispersing agent is selected from the group consisting of polyvinylpyrrolidone, polyvinylalcohol and derivatives, glycerine, polyethylene oxide, poly(dimethyl acrylamide), poly(N-vinyl-N-methylacetamide), cysteine, methionine, sodium sulfide, sodium thiosulfate, and sodium thiocyanate.

29. The antimicrobial lens of claim 16 wherein the dispersing agent is polyvinylpyrrolidone K90.

30. The antimicrobial lens of claim 16 wherein the swelling agent is selected from the group consisting of extracting solvents as disclosed in U.S. Pat. No. 7,112,652.