NAPHTHYLPYRIMIDINE, NAPHTHYLPYRAZINE AND NAPHTHYLPYRIDAZINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM

• US 20090054392A1
• Filed: 08/19/2008
• Published: 02/26/2009
• Est. Priority Date: 08/20/2007
• Status: Abandoned Application

• Current Assignee: Wyeth LLC (Pfizer Inc.)
• Original Assignee: Wyeth (Pfizer Inc.)
• Inventors: Vera, Matthew Douglas, Rogers, John Francis JR., Molinari, Albert John, Mehlmann, John Francis, Lundquist, Joseph Theodore IV, Pelletier, Jeffrey Claude, Mann, Charles William, Hauze, Diane Barbara, Green, Daniel Michael, Felix, Luciana de Araujo
• Application Number:
  US12/194,235
• Publication Number:
  US 20090054392A1
• Time in Patent Office: Days
• US Class Current: 514/210.200
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 239/26 with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• CPC Class Codes: C07D 239/34 One oxygen atom
• CPC Class Codes: C07D 401/06 linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 403/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 451/02 containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
• CPC Class Codes: C07D 471/04 Ortho-condensed systems
• CPC Class Codes: C07D 471/10 Spiro-condensed systems
• CPC Class Codes: C07D 487/04 Ortho-condensed systems
• CPC Class Codes: C07D 487/08 Bridged systems

Abstract

The present invention relates to naphthylpyrimidine analogs, methods of making naphthylpyrimidine analogs, compositions comprising a naphthylpyrimidine analog, and methods for treating canonical Wnt-β-catenin cellular messaging system-related disorders comprising administering to a subject in need thereof an effective amount of a naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analog.

Claims

1. A compound of Formula (A):

2. The compound of claim 1, wherein R₇ is H or OR₁₁.

3. The compound of claim 1, wherein R₅ is 5-10-membered heteroaryl.

4. The compound of claim 3, wherein R₅ is 5-7-membered heteroaryl

5. The compound of claim 1, wherein Q is a bond or N(CH₂)_rR₈.

6. The compound of claim 5, wherein Q is a bond.

7. The compound of claim 1, wherein r is 0, 1 or 2.

8. The compound of claim 1, wherein R₈ is H.

9. The compound of claim 1, wherein Formula (A) is Formula (AI):

10. The compound of claim 1, wherein the 3- to 7-membered heterocycle formed by R₃ and R₄ is a 5, 6, or 7-membered heteroaryl.

11. The compound of claim 1, wherein the 3- to 7-membered heterocycle formed by R₅ and R₄ is a 5, 6, or 7-membered heteroaryl.

12. The compound of claim 1, wherein the 3- to 7-membered heterocycle formed by R₁₁ and R₁₂ is a 5, 6, or 7-membered heteroaryl.

13. The compound of claim 1, wherein 3- to 7-membered heterocycle formed by R₁₃ and R₁₄ is a 5, 6, or 7-membered heteroaryl.

14. The compound of claim 1, wherein the R₁₁ is Cl-C₆ alkyl optionally substituted with a 5-7 membered heteroaryl.

15. The compound of claim 1, wherein

16. The compound of claim 1, wherein

17. The compound of claim 16, wherein n=1 and m=1.

18. The compound of claim 16, wherein n=1 and m=0.

19. The compound of claim 16, where n=2 and m=0.

20. The compound of claim 16, wherein R₂ is CH₂OR₁₁.

21. The compound of claim 16, wherein R₃ is OR₁₁ or CH₂OR₁₁.

22. The compound of claim 16, wherein R₄ is OR₁₁.

23. The compound of claim 16, wherein R₅ is CN;

N R₁₁R₁₂;

C(S)N R₁₁R₁₂;

or alkyl optionally substituted with N R₁₁R₁₂, monocyclic heterocycle, or bicyclic heterocycle.

24. The compound of claim 16, wherein

25. The compound of claim 16, wherein

26. The compound of claim 25, wherein

27. The compound of claim 15, wherein

28. The compound of claim 1, wherein Formula (A) is

29. The compound of claim 1, wherein Formula (A) is Formula (I):

31. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is

tert-butyl {(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamate;

(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane-1-carbaldehyde;

1-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane;

1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-amine;

tert-butyl {1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}carbamate;

tert-butyl ({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)carbamate;

1-{1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl }methanamine;

tert-butyl ({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)carbamate;

1-{1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methanamine;

4-(2-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}ethyl)morpholine;

4-({4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}acetyl)morpholine;

N,N-dimethyl-2-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}ethanamine;

2-(4-methylpiperazin-1-yl)-4-(2-naphthyl)pyrimidine;

4-(2-naphthyl)-2-(4-pyridin-2-ylpiperazin-1-yl)pyrimidine;

4-(2-naphthyl)-2-(4-pyrimidin-2-ylpiperazin-1-yl)pyrimidine;

1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;

2-[4-(2-naphthyl)pyrimidin-2-yl]-1,2,3,4-tetrahydroisoquinoline;

(2-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}ethyl)amine;

N,N-dimethyl-3-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}propan-1-amine;

4-(2-naphthyl)-2-(4-pyridin-4-ylpiperazin-1-yl)pyrimidine;

4-(3-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}propyl)morpholine;

2-[4-(2-furoyl)piperazin-1-yl]-4-(2-naphthyl)pyrimidine;

tert-butyl {(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamate;

(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

N,N-dimethyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

N,N-diethyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

(3R)-N-methyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

(3S)-N-methyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

(3S)-N,N-dimethyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

(3R)-N,N-dimethyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

N-methyl-N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}acetamide;

{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanol;

2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethanol;

ethyl 1-[4-(2-naphthyl)pyrimidin-2-yl]piperidine-4-carboxylate;

ethyl {1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}acetate;

{(2S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-2-yl}methanol;

1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-ol;

4-[4-(2-naphthyl)pyrimidin-2-yl]morpholine;

{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-2-yl}methanol;

{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-3-yl}methanol;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-ol;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-3-ol;

{(2R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-2-yl}methanol;

4-(2-naphthyl)-2-pyrrolidin-1-ylpyrimidine;

4-(2-naphthyl)-2-piperidin-1-ylpyrimidine;

2-(4-methylpiperidin-1-yl)-4-(2-naphthyl)pyrimidine;

1-[4-(2-naphthyl)pyrimidin-2-yl]azepane;

tert-butyl {1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}carbamate;

tert-butyl 4-[4-(2-naphthyl)pyrimidin-2-yl]piperazine-1-carboxylate;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-amine;

4-(2-naphthyl)-2-piperazin-1-ylpyrimidine;

tert-butyl ({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-3-yl}methyl)carbamate;

({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-3-yl}methyl)amine;

(1R,5S,6s)-3-[4-(2-naphthyl)pyrimidin-2-yl]-3-azabicyclo[3.1.0]hexan-6-amine;

({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)amine;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidine-4-carboxamide;

8-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-dioxa-8-azaspiro[4.5]decane;

methyl 1-[4-(2-naphthyl)pyrimidin-2-yl]piperidine-4-carboxylate;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidine-3-carboxamide;

{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-3-yl}methanol;

{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-3-yl}methanol;

N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}acetamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)guanidine;

N-ethyl-4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane-1-carboxamide;

methyl 4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane-1-carboxylate;

ethyl 4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane-1-carboxylate;

1-acetyl-4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane;

1-[4-(2-naphthyl)pyrimidin-2-yl]-4-propionyl-1,4-diazepane;

1-[4-(2-naphthyl)pyrimidin-2-yl]-4-(trifluoroacetyl)-1,4-diazepane;

N,N-diethyl-4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane-1-carboxamide;

1-(methylsulfonyl)-4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane;

N,N-dimethyl-4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane-1-sulfonamide;

N,N-dimethyl-4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane-1-carboxamide;

4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane-1-carboxamide;

1-benzoyl-4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane;

1-[(4-methylphenyl)sulfonyl]-4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane;

N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}acetamide;

2,2,2-trifluoro-N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}acetamide;

N,N-dimethyl-N′

-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}urea;

N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}benzamide;

N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}urea;

N-ethyl-N′

-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}urea;

N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}methanesulfonamide;

4-methyl-N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}benzenesulfonamide;

N,N-dimethyl-N′

-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}sulfamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)acetamide;

2,2,2-trifluoro-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)acetamide;

N,N-dimethyl-N′

-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)urea;

methyl ({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)carbamate;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)urea;

N-ethyl-N′

-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)urea;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)methanesulfonamide;

4-methyl-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)benzenesulfonamide;

{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}formamide;

N,N-dimethyl-N′

-(2-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}ethyl)urea;

N-(2-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}ethyl)methanesulfonamide;

N-(2-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}ethyl)dicarbonimidic diamide;

N-ethyl-N′

-(2-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}ethyl)urea;

N-isopropyl-N′

-(2-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}ethyl)urea;

diethyl (2-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}ethyl)imidodicarbonate;

N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}acetamide;

2,2,2-trifluoro-N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}acetamide;

methyl {(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamate;

N,N-dimethyl-N′

-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}urea;

N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}pyrrolidine-1-carboxamide

N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}urea;

N,N-dimethyl-N′

-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}sulfamide;

N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methanesulfonamide;

4-methyl-N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}benzenesulfonamide;

N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}morpholine-4-carboxamide;

ethyl {(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamate;

N-isopropyl-N′

-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}urea;

N,N-diethyl-N′

-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}urea;

N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}guanidine;

4-chloro-N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}benzamide;

4-cyano-N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}benzamide;

N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}acetamide;

2,2,2-trifluoro-N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}acetamide;

N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}benzamide;

methyl {(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamate;

N,N-dimethyl-N′

-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}urea;

N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}pyrrolidine-1-carboxamide

N-ethyl-N′

-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}urea;

N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}urea;

N,N-dimethyl-N′

-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}sulfamide;

N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methanesulfonamide;

4-methyl-N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}benzenesulfonamide;

N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}morpholine-4-carboxamide;

ethyl {(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamate;

N-isopropyl-N′

-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}urea;

N,N-diethyl-N′

-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}urea;

4-chloro-N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}benzamide;

4-cyano-N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}benzamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)acetamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)benzamide;

methyl ({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)carbamate;

N,N-dimethyl-N′

-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)urea;

N-ethyl-N′

-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)urea;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)urea;

N,N-dimethyl-N′

-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)sulfamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)methanesulfonamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)formamide;

N-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)acetamide;

2,2,2-trifluoro-N-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)acetamide;

methyl (2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)carbamate;

N,N-dimethyl-N′

-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)urea;

N,N-diethyl-N′

-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)urea;

N-ethyl-N′

-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)urea;

N-isopropyl-N′

-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)urea;

N-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)urea;

N-cyclohexyl-N′

-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)urea;

N-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)pyrrolidine-1-carboxamide;

N-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)morpholine-4-carboxamide;

N,N-dimethyl-N′

-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)sulfamide;

N-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)methanesulfonamide;

benzyl (2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)carbamate;

N-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)-N′

-phenylurea;

N-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)benzamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)acetamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)acetamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide;

methyl ({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)carbamate;

N,N-dimethyl-N′

-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)urea;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)pyrrolidine-1-carboxamide

N-ethyl-N′

-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)urea;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)urea;

N,N-dimethyl-N′

-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)sulfamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)methanesulfonamide;

4-methyl-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzenesulfonamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)pyrimidin-2-amine;

di-tert-butyl {(Z)-[({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl) amino]methylylidene}biscarbamate;

di-tert-butyl ((E)-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}methylylidene)biscarbamate;

4-[4-(2-naphthyl)pyrimidin-2-yl]piperazine-1-carboximidamide;

{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl 4-methylbenzenesulfonate;

2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl methanesulfonate;

2-[4-(2-azidoethyl)piperidin-1-yl]-4-(2-naphthyl)pyrimidine;

N,N-dimethyl-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanamine;

N-methyl-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanamine;

2-[4-(1H-imidazol-1-ylmethyl)piperidin-1-yl]-4-(2-naphthyl)pyrimidine;

4-(2-naphthyl)-2-[4-(pyrrolidin-1-ylmethyl)piperidin-1-yl]pyrimidine;

N-ethyl-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)ethanamine;

4-(2-naphthyl)-2-[4-(piperidin-1-ylmethyl)piperidin-1-yl]pyrimidine;

4-(2-naphthyl)-2-[4-(piperidin-1-ylmethyl)piperidin-1-yl]pyrimidine;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)ethanamine;

2-methyl-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)propan-1-amine;

2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethanamine;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-one;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidine-4-carbaldehyde;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidine-4-carboxylic acid;

4-methyl-1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-ol;

1-[4-(2-naphthyl)pyrimidin-2-yl]-4-(nitromethyl)piperidin-4-ol;

4-(aminomethyl)-1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-ol;

1-[4-(2-naphthyl)pyrimidin-2-yl]-4-(1-nitroethyl)piperidin-4-ol;

4-(2-naphthyl)-2-[4-(1-nitroethyl)piperidin-1-yl]pyrimidine;

4-(2-naphthyl)-2-[4-(nitromethyl)piperidin-1-yl]pyrimidine;

tert-butyl ((1S)-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)carbamate;

tert-butyl (1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)carbamate;

1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethanamine;

(1R)-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethanamine;

(1S)-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethanamine;

4-{[4-(2-naphthyl)pyrimidin-2-yl]methyl}-1,4-diazepane-1-carbaldehyde;

1-(1-{[4-(2-naphthyl)pyrimidin-2-yl]methyl}piperidin-4-yl)methanamine;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidine-4-carbonitrile;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidine-4-carbothioamide;

2-azetidin-1-yl-4-(2-naphthyl)pyrimidine;

2-azetidin-1-yl-4-(2-naphthyl)pyrimidine;

2-[4-(azidomethyl)piperidin-1-yl]-4-(2-naphthyl)pyrimidine;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidine-4-carboximidamide;

methyl [(tert-butoxycarbonyl)amino]{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-ylidene}acetate;

methyl [(tert-butoxycarbonyl)amino]{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}acetate;

methyl (2R)-[(tert-butoxycarbonyl)amino]{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}acetate;

methyl (2S)-[(tert-butoxycarbonyl)amino]{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}acetate;

methyl amino {1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}acetate;

methyl (2R)-amino {1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}acetate;

methyl (2S)-amino {1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}acetate;

(2R)-2-amino-2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethanol;

tert-butyl ((1R)-2-hydroxy-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)carbamate;

tert-butyl ((1S)-2-hydroxy-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)carbamate;

tert-butyl ((1R)-2-hydroxy-2-methyl-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}propyl)carbamate;

(1R)-1-amino-2-methyl-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4yl}propan-2-ol;

(4R)-5,5-dimethyl-4-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}-1,3-oxazolidin-2-one;

(4R)-4-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}-1,3-oxazolidin-2-one;

or

(1-(4-(naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanol.

33. A compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is:

1-{1-[2-(2-naphthyl)pyrimidin-4-yl]piperidin-4-yl}methanamine;

1-{1-[6-(2-naphthyl)pyrimidin-4-yl]piperidin-4-yl}methanamine;

1-{1-[5-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanamine;

1-{1-[6-(2-naphthyl)pyrazin-2-yl]piperidin-4-yl}methanamine;

1-{1-[5-(2-naphthyl)pyridazin-3-yl]piperidin-4-yl}methanamine;

1-{1-[4-(2-naphthyl)pyrimidin-2-yl]-1,2,3,4-tetrahydroquinolin-4-yl}methanamine;

1-{(4S)-1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}methanamine;

1-{(4R) 1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}methanamine;

1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-amine;

N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}acetamide;

2,2,2-trifluoro-N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}acetamide;

N,N-dimethyl-N′

-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}urea;

N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}benzamide;

N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}urea;

N-ethyl-N′

-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}urea;

N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}methanesulfonamide;

4-methyl-N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}benzenesulfonamide;

N,N-dimethyl-N′

-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}sulfamide;

{(1S,4R)-2-[4-(2-naphthyl)pyrimidin-2-yl]-2-azabicyclo[2.2.1]heptane-5,5-diyl}dimethanamine;

1-{(1R,4R,5R)-2-[4-(2-naphthyl)pyrimidin-2-yl]-2-azabicyclo[2.2.1]hept-5-yl}methanamine;

1-{(1R,4R,5S)-2-[4-(2-naphthyl)pyrimidin-2-yl]-2-azabicyclo[2.2.1]hept-5-yl}methanamine;

1-{(1S,4S,5S)-2-[4-(2-naphthyl)pyrimidin-2-yl]-2-azabicyclo[2.2.1]hept-5-yl}methanamine;

1-{(1S,4S,5R)-2-[4-(2-naphthyl)pyrimidin-2-yl]-2-azabicyclo[2.2.1]hept-5-yl}methanamine;

1-{8-[4-(2-naphthyl)pyrimidin-2-yl]-8-azabicyclo[3.2.1]oct-3-yl}methanamine;

1-{8-[4-(2-naphthyl)pyrimidin-2-yl]-8-azabicyclo[3.2.1]oct-3-yl}methanamine;

2-[4-(2-naphthyl)pyrimidin-2-yl]-2, 8-diazaspiro[4.5]decane;

N,N,N′

-trimethyl-N′

-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethane-1,2-diamine;

(3aR* ,6aS)-2-[4-(2-naphthyl)pyrimidin-2-yl]octahydropyrrolo[3,4-c]pyrrole;

5-(4-naphthalen-2-ylpyrimidin-2-yl)octahydropyrrolo [3,4-b]pyrrole;

1-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)piperidin-4-ol;

(3S)-1-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)piperidin-3-ol;

(3R)-1-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)piperidin-3-ol;

(3S)-1-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)pyrrolidin-3-ol;

(3R)-1-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)pyrrolidin-3-ol;

(3S,3′

R)-1′

-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′

-bipyrrolidin-3-ol;

2-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}octahydro-2H-pyrido[1,2-a]pyrazine;

(3S,3′

R)-1′

-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′

-bipyrrolidin-3-amine;

3-(methyl {(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)propan-1-ol;

N,N-dimethyl-N′

-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethane-1,2-diamine;

N,N′

-dimethyl-N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethane-1,2-diamine;

(3R,3′

R)-1′

-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′

-bipyrrolidin-3-ol;

(3R,3′

R)-1′

-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′

-bipyrrolidin-3-amine;

(1S,4S)-2-methyl-5-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}-2,5-diazabicyclo[2.2.1]heptane;

5-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}octahydropyrrolo[3,4b]-pyrrole;

N,N,N′

-trimethyl-N′

-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}propane-1,3-diamine;

(3R,3′

S)-1′

-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′

-bipyrrolidin-3-ol;

(3S,3′

S)-1′

-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′

-bipyrrolidin-3-ol;

N,N-dimethyl-N′

-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethane-1,2-diamine;

N,N,N′

-trimethyl-N′

-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethane-1,2-diamine

3-(methyl{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)propan-1-ol;

5-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}octahydropyrrolo[3,4-b]pyrrole;

N,N,N′

-trimethyl-N′

-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}propane-1,3-diamine;

2-(ethyl{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethanol;

2-[(3S)-3-(1H-imidazol-1-yl)pyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

(3S)-N-cyclohexyl-N-methyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

(3S)-N-(tert-butyl)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

4-(2-naphthyl)-2-[(3S)-3-piperazin-1-ylpyrrolidin-1-yl]pyrimidine;

4-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}morpholine;

4-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperazin-2-one;

1-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}azepane;

(3′

S)-1′

-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′

-bipyrrolidine;

4-(2-naphthyl)-2-[(3S)-3-piperidin-1-ylpyrrolidin-1-yl]pyrimidine;

2-[(3S)-3-(4-methylpiperazin-1-yl)pyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

(1-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-3-yl)methanol;

(1-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-4-yl)methanol;

1-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-3-ol;

(3S)-N-(2-morpholin-4-ylethyl)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

1-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-4-ol;

(3R,3′

S)-N,N-dimethyl-1′

-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′

-bipyrrolidin-3-amine;

(3S,3′

S)-N,N-dimethyl-1′

-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′

-bipyrrolidin-3-amine;

(3R)-1-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-3-ol;

(3S)-1-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-3ol;

2-(ethyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethanol;

2-[(3R)-3-(1H-imidazol-1-yl)pyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

(3R)-N-cyclohexyl-N-methyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

(3R)-N-(tert-butyl)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

4-(2-naphthyl)-2-[(3R)-3-piperazin-1-ylpyrrolidin-1-yl]pyrimidine;

4-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}morpholine;

4-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperazin-2-one;

1-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}azepane;

(3′

R)-1′

-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′

-bipyrrolidine;

4-(2-naphthyl)-2-[(3R)-3-piperidin-1-ylpyrrolidin-1-yl]pyrimidine;

2-[(3R)-3-(4-methylpiperazin-1-yl)pyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

(1-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-3-yl)methanol;

(1-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-4-yl)methanol;

1-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-3-ol;

(3R)-N-(2-morpholin-4-ylethyl)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

1-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-4-ol;

(3R,3′

R)-N,N-dimethyl-1′

-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′

-bipyrrolidin-3-amine;

(3S,3′

R)-N,N-dimethyl-1′

-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′

-bipyrrolidin-3-amine;

(3R)-1-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-3-ol;

(3S)-1-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-3-ol;

{1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methanol;

1-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)azepane;

4-(2-naphthyl)-2-[3-(piperidin-1-ylmethyl)pyrrolidin-1-yl]pyrimidine;

4-(2-naphthyl)-2-[3-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]pyrimidine;

2-[3-(azetidin-1-ylmethyl)pyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

4-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)morpholine;

4-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)thiomorpholine;

N-ethyl-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)ethanamine;

2-methyl-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)propan-2-amine;

2-[ethyl({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl) amino]ethanol;

2-{3-[(4-methylpiperazin-1-yl)methyl]pyrrolidin-1-yl}-4-(2-naphthyl)pyrimidine;

4-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)piperazin-2-one;

2-[3-(1H-imidazol-1-ylmethyl)pyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

2-[3-(chloromethyl)pyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

N,N-dimethyl-1-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methanamine;

4-(2-naphthyl)-2-[(3S)-3-(piperidin-1-ylmethyl)pyrrolidin-1-yl]pyrimidine;

4-(2-naphthyl)-2-[(3S)-3-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]pyrimidine;

N-methyl-1-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methanamine;

N-methyl-N-({(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)cyclohexanamine;

1-({(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)piperidin-2-one;

tert-butyl 4-({(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)piperazine-1-carboxylate;

2-methyl-N-({(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)propan-2-amine;

2-[ethyl({(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)amino]ethanol;

2-{(3S)-3-[(4-methylpiperazin-1-yl)methyl]pyrrolidin-1-yl}-4-(2-naphthyl)pyrimidine;

(3S)-N,N-dimethyl-1-({(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)pyrrolidin-3-amine;

2-[(3R)-3-(1H-imidazol-1-ylmethyl)pyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

(3R)-N,N-dimethyl-1-({(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)pyrrolidin-3-amine;

N,N-dimethyl-1-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methanamine;

4-(2-naphthyl)-2-[(3R)-3-(piperidin-1-ylmethyl)pyrrolidin-1-yl]pyrimidine;

4-(2-naphthyl)-2-[(3R)-3-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]pyrimidine;

N-methyl-1-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methanamine;

N-methyl-N-({(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)cyclohexanamine;

1-({(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)piperidin-2-one;

tert-butyl 4-({(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)piperazine-1-carboxylate;

2-methyl-N-({(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)propan-2-amine;

2-[ethyl({(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)amino]ethanol;

2-{(3R)-3-[(4-methylpiperazin-1-yl)methyl]pyrrolidin-1-yl}-4-(2-naphthyl)pyrimidine;

(3S)-N,N-dimethyl-1-({(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)pyrrolidin-3-amine;

2-[(3S)-3-(1H-imidazol-1-ylmethyl)pyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

(3R)-N,N-dimethyl-1-({(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)pyrrolidin-3-amine;

N,N-dimethyl-1-[4-(2-naphthyl)pyrimidin-2-yl]-L-prolinamide;

4-(2-naphthyl)-2-[(2S)-2-(piperidin-1-ylcarbonyl)pyrrolidin-1-yl]pyrimidine;

4-(2-naphthyl)-2-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]pyrimidine;

N-tert-butyl-1-[4-(2-naphthyl)pyrimidin-2-yl]-L-prolinamide;

N-ethyl-N-(2-hydroxyethyl)-1-[4-(2-naphthyl)pyrimidin-2-yl]-L-prolinamide;

2-{(2S)-2-[(4-methylpiperazin-1-yl)carbonyl]pyrrolidin-1-yl}-4-(2-naphthyl)pyrimidine;

(3S)-N,N-dimethyl-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]-L-prolyl}pyrrolidin-3-amine;

(3R)-N,N-dimethyl-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]-L-prolyl}pyrrolidin-3-amine;

N,N-dimethyl-1-[4-(2-naphthyl)pyrimidin-2-yl]-D-prolinamide;

4-(2-naphthyl)-2-[(2R)-2-(piperidin-1-ylcarbonyl)pyrrolidin-1-yl]pyrimidine;

4-(2-naphthyl)-2-[(2R)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]pyrimidine;

N-methyl-1-[4-(2-naphthyl)pyrimidin-2-yl]-D-prolinamide;

N-tert-butyl-1-[4-(2-naphthyl)pyrimidin-2-yl]-D-prolinamide;

2-{(2R)-2-[(4-methylpiperazin-1-yl)carbonyl]pyrrolidin-1-yl}-4-(2-naphthyl)pyrimidine;

(3S)-N,N-dimethyl-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]-D-prolyl}pyrrolidin-3-amine;

(3R)-N,N-dimethyl-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]-D-prolyl}pyrrolidin-3-amine;

(3′

S)-1′

-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′

-bipyrrolidin-2-one;

(3′

R)-1′

-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′

-bipyrrolidin-2-one;

tert-butyl {(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamate;

2-[(3R)-3-methoxypyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

2-[(3S)-3-methoxypyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

2,2,2-trifluoro-N-(2-{(2S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-2-yl}ethyl)acetamide;

2,2,2-trifluoro-N-(2-{(2R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-2-yl}ethyl)acetamide;

(3R)-N-methyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

(3S)-N-methyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

(3R)-N,N-dimethyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]-N-(2,2,2-trifluoroethyl)pyrrolidin-3-amine;

N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}-N-(2,2,2-trifluoroethyl)acetamide;

2-{(2R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-2-yl}ethanamine;

2-{(2S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-2-yl}ethanamine;

2-{1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethanamine;

N-methyl-N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}acetamide;

N-ethyl-N,N′

-dimethyl-N′

-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethane-1,2-diamine;

N,N′

-dimethyl-N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}-N′

-propylethane-1,2-diamine;

N-isopropyl-N,N′

-dimethyl-N′

-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethane-1,2-diamine;

N-benzyl-N,N′

-dimethyl-N′

-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethane-1,2-diamine;

N-methyl-N-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]acetamide;

2,2,2-trifluoro-N-methyl-N-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]acetamide;

N-methyl-N-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]propanamide;

N,2-dimethyl-N-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]propanamide;

N-methyl-N-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]methanesulfonamide;

b 1,1-diethyl-3-methyl-3-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidine-3-yl}amino)ethyl]urea;

methyl methyl[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]carbamate;

N-methyl-N-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]ethanesulfonamide;

N,N,N′

-trimethyl-N′

-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]sulfamide;

N-methyl-N-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]benzamide;

N-methyl-N-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]benzenesulfonamide;

tert-butyl ({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)carbamate;

1-{1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methanamine;

methyl ({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)carbamate;

2,2,2-trifluoro-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)acetamide;

N,N-dimethyl-N′

-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)urea;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)urea;

N-ethyl-N′

-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)urea;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)methanesulfonamide;

4-methyl-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)benzenesulfonamide;

tert-butyl {2-[1-(4-naphthalen-2-ylpyrimidin-2-yl)azetidin-3-yl]ethyl}carbamate;

2-[1-(4-naphthalen-2-ylpyrimidin-2-yl)azetidin-3-yl]ethanamine;

tert-butyl [(trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]oxy}cyclohexyl)methyl]carbamate;

1-(trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]oxy}cyclohexyl)methanamine;

tert-butyl ({cis-4-[(4-naphthalen-2-ylpyrimidin-2-yl)oxy]cyclohexyl}methyl)carbamate;

1-{cis-4-[(4-naphthalen-2-ylpyrimidin-2-yl)oxy]cyclohexyl}methanamine;

N-[trans-4-(aminomethyl)cyclohexyl]-N-methyl-4-(2-naphthyl)pyrimidin-2-amine;

benzyl [(cis-4-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)methyl]carbamate;

N-[cis-4-(aminomethyl)cyclohexyl]-N-methyl-4-(2-naphthyl)pyrimidin-2-amine;

1-{4-[4-(2-naphthyl)pyrimidin-2-yl]phenyl}methanamine;

1-[trans-4-(4-naphthalen-2-ylpyrimidin-2-yl)cyclohexyl]methanamine;

1-{cis-4-[4-(2-naphthyl)pyrimidin-2-yl]cyclohexyl}methanamine;

1-{1-[4-(6-methoxy-2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanamine;

1-{1-[4-(6-propoxy-2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanamine;

1-{1-[4-(6-isobutoxy-2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanamine;

6-{2-[4-(aminomethyl)piperidin-1-yl]pyrimidin-4-yl}-2-naphthyl acetate;

6-{2-[4-(aminomethyl)piperidin-1-yl]pyrimidin-4-yl}-2-naphthol;

2,2,2-trifluoro-N-({1-[4-(6-hydroxy-2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)acetamide;

2,2,2-trifluoro-N-({1-[4-(6-methoxy-2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)acetamide;

1-(1-{4-[6-(2-thienyl)-2-naphthyl]pyrimidin-2-yl}piperidin-4-yl)methanamine;

1-(1-{4-[6-(2-methoxyphenyl)-2-naphthyl]pyrimidin-2-yl}piperidin-4-yl)methanamine;

1-(1-{4-[6-(4-methoxyphenyl)-2-naphthyl]pyrimidin-2-yl}piperidin-4-yl)methanamine;

1-{1-[4-(6-phenyl-2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanamine;

2,2,2-trifluoro-N-({1-[4-(6-formyl-2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)acetamide;

1-{1-[4-(6-vinyl-2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanamine;

1-{1-[4-(6-methyl-2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanamine;

1-(1-{4-[6-(piperidin-1-ylmethyl)-2-naphthyl]pyrimidin-2-yl}piperidin-4-yl)methanamine;

1-(1-{4-[6-(morpholin-4-ylmethyl)-2-naphthyl]pyrimidin-2-yl}piperidin-4-yl)methanamine;

2-{4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl}-4-(2-naphthyl)pyrimidine;

N-methyl-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)cyclohexanamine;

1-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)azepane;

2-[ethyl({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)amino]ethanol;

2-methyl-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)propan-2-amine;

1-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)pyrrolidin-2-one;

1-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)piperidin-2-one;

4-(2-naphthyl)-2-[4-(piperazin-1-ylmethyl)piperidin-1-yl]pyrimidine;

4-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)morpholine;

4-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)piperazin-2-one;

1-(1-{[4-(2-naphthyl)pyrimidin-2-yl]carbonyl}piperidin-4-yl)methanamine;

or

(3aR,7aS)-5-[4-(2-naphthyl)pyrimidin-2-yl]octahydro-1H-pyrrolo[3,4-c]pyridine.

34. A compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is N,N,N′

-trimethyl-N′

-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethane-1,2-diamine.

35. A compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is ({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)amine.

36. A composition comprising the compound or pharmaceutically acceptable salt of the compound of claim 1 or 30 and a pharmaceutically acceptable carrier.

37. The composition of claim 36, wherein the pharmaceutically acceptable carrier is suitable for oral administration and the composition comprises an oral dosage form.

38. A method of treating a canonical Wnt-β

-catenin cellular messaging system related disorder, comprising administering to a mammal in need thereof a compound or a pharmaceutically acceptable salt thereof the compound of claim 1 or 30 in an amount effect to treat a canonical Wnt-β

-catenin cellular messaging system related disorder.

39. The method of claim 38, wherein the canonical Wnt-β

-catenin cellular messaging system related disorder is selected from the group consisting of bone disorders, cancer, and Alzheimer'"'"'s disease.

40. The method of claim 39, wherein the cancer is selected from the group consisting of leukemia, skin cancer, bladder cancer, breast cancer, uterus cancer, ovary cancer, prostate cancer, lung cancer, colon cancer, pancreas cancer, renal cancer, gastric cancer, and brain cancer.

41. The method of claim 39, wherein the bone disorder is selected from the group consisting of osteoarthritis, osteolysis from multiple myeloma, osteoporosis, and rheumatoid arthritis.

42. The method of claim 38, wherein the mammal is human.

44. A process for preparing a compound of Formula (a)

45. The process of claim 44, the process further comprising preparing a compound of Formula (c)

46. The process of claim 44, wherein the base is EtONa.

30. A compound of the Formula (II):

32. The compound of claim 30, or a pharmaceutically acceptable salt thereof, wherein the compound is

N-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-amine;

tert-butyl 3-({[4-(2-naphthyl)pyrimidin-2-yl]amino }methyl)azetidine-1-carboxylate;

N-(azetidin-3-ylmethyl)-4-(2-naphthyl)pyrimidin-2-amine;

tert-butyl (3S)-3-({[4-(2-naphthyl)pyrimidin-2-yl]amino }methyl)pyrrolidine-1-carboxylate;

4-(2-naphthyl)-N-[(3R)-pyrrolidin-3-ylmethyl]pyrimidin-2-amine;

N-(2-morpholin-4-ylethyl)-4-(2-naphthyl)pyrimidin-2-amine;

N-(3-morpholin-4-ylpropyl)-4-(2-naphthyl)pyrimidin-2-amine;

4-(2-naphthyl)-N-(pyridin-3-ylmethyl)pyrimidin-2-amine;

4-(2-naphthyl)-N-(pyridin-4-ylmethyl)pyrimidin-2-amine;

4-(2-naphthyl)-N-(pyridin-2-ylmethyl)pyrimidin-2-amine;

4-({[4-(2-naphthyl)pyrimidin-2-yl]amino }methyl)benzenesulfonamide;

4-(2-naphthyl)-N-(2-pyridin-3-ylethyl)pyrimidin-2-amine;

4-(2-naphthyl)-N-(2-pyridin-4-ylethyl)pyrimidin-2-amine;

tert-butyl (3S)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxylate;

tert-butyl (3R)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxylate;

4-(2-naphthyl)-N-[(3S)-pyrrolidin-3-yl]pyrimidin-2-amine;

4-(2-naphthyl)-N-[(3R)-pyrrolidin-3-yl]pyrimidin-2-amine;

tert-butyl (3R)-3-({[4-(2-naphthyl)pyrimidin-2-yl]amino }methyl)pyrrolidine-1-carboxylate;

4-(2-naphthyl)-N-[(3S)-pyrrolidin-3-ylmethyl]pyrimidin-2-amine;

4-(2-naphthyl)-N-(piperidin-4-ylmethyl)pyrimidin-2-amine;

tert-butyl 4-({[4-(2-naphthyl)pyrimidin-2-yl]amino }methyl)piperidine-1-carboxylate;

trans-N-[4-(2-naphthyl)pyrimidin-2-yl]cyclohexane-1,4-diamine;

N-(4-methoxybenzyl)-4-(2-naphthyl)pyrimidin-2-amine;

N-[2-(4-methylphenyl)ethyl]-4-(2-naphthyl)pyrimidin-2-amine;

2-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}ethanol;

N-(2-methoxyethyl)-4-(2-naphthyl)pyrimidin-2-amine;

2-{[4-(2-naphthyl)pyrimidin-2-yl]amino }ethanol;

N-(2-methoxyethyl)-N-methyl-4-(2-naphthyl)pyrimidin-2-amine;

N-methyl-4-(2-naphthyl)pyrimidin-2-amine;

N,N-diethyl-4-(2-naphthyl)pyrimidin-2-amine;

4-(2-naphthyl)-N-propylpyrimidin-2-amine;

N-butyl-4-(2-naphthyl)pyrimidin-2-amine;

N-isopropyl-4-(2-naphthyl)pyrimidin-2-amine;

N-(sec-butyl)-4-(2-naphthyl)pyrimidin-2-amine;

N-isobutyl-4-(2-naphthyl)pyrimidin-2-amine;

N-(tert-butyl)-4-(2-naphthyl)pyrimidin-2-amine;

N-benzyl-4-(2-naphthyl)pyrimidin-2-amine;

4-(2-naphthyl)-N-(2-phenylethyl)pyrimidin-2-amine;

N-cyclopentyl-4-(2-naphthyl)pyrimidin-2-amine;

N-cyclohexyl-4-(2-naphthyl)pyrimidin-2-amine;

tert-butyl 4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxylate;

4-(2-naphthyl)-N-piperidin-4-ylpyrimidin-2-amine;

tert-butyl 4- {methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxylate;

N-methyl-4-(2-naphthyl)-N-piperidin-4-ylpyrimidin-2-amine;

tert-butyl 4-(2-methoxy-1-{[4-(2-naphthyl)pyrimidin-2-yl]amino}-2-oxoethyl)piperidine-1-carboxylate;

4-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carbaldehyde;

N-(1-benzylpiperidin-4-yl)-N-methyl-4-(2-naphthyl)pyrimidin-2-amine;

N-[(1-acetylazetidin-3-yl)methyl]-4-(2-naphthyl)pyrimidin-2-amine;

4-(2-naphthyl)-N-{[1-(trifluoroacetyl)azetidin-3-yl]methyl}pyrimidin-2-amine;

N-[(1-benzoylazetidin-3-yl)methyl]-4-(2-naphthyl)pyrimidin-2-amine;

3-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)azetidine-1-carboxamide;

N-ethyl-3-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)azetidine-1-carboxamide;

N-{[1-(methylsulfonyl)azetidin-3-yl]methyl}-4-(2-naphthyl)pyrimidin-2-amine;

N-({1-[(4-methylphenyl)sulfonyl]azetidin-3-yl}methyl)-4-(2-naphthyl)pyrimidin-2-amine;

N,N-dimethyl-3-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)azetidine-1-sulfonamide;

N-[(3S)-1-acetylpyrrolidin-3-yl]-4-(2-naphthyl)pyrimidin-2-amine;

N-[(3S)-1-benzoylpyrrolidin-3-yl]-4-(2-naphthyl)pyrimidin-2-amine;

methyl (3S)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxylate;

(3S)-N,N-dimethyl-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxamide;

(3S)-N-ethyl-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxamide;

(3S)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxamide;

(3S)-N,N-dimethyl-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-sulfonamide;

N-[(3S)-1-(methylsulfonyl)pyrrolidin-3-yl]-4-(2-naphthyl)pyrimidin-2-amine;

N-{(3S)-1-[(4-methylphenyl)sulfonyl]pyrrolidin-3-yl}-4-(2-naphthyl)pyrimidin-2-amine;

(3S)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carbaldehyde;

N-[(3S)-1-(morpholin-4-ylcarbonyl)pyrrolidin-3-yl]-4-(2-naphthyl)pyrimidin-2-amine;

ethyl (3S)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxylate;

N-[(3R)-1-acetylpyrrolidin-3-yl]-4-(2-naphthyl)pyrimidin-2-amine;

N-[(3R)-1-benzoylpyrrolidin-3-yl]-4-(2-naphthyl)pyrimidin-2-amine;

methyl (3R)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxylate;

(3R)-N,N-dimethyl-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxamide;

(3R)-N-ethyl-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxamide;

(3R)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxamide;

(3R)-N,N-dimethyl-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-sulfonamide;

N-[(3R)-1-(methylsulfonyl)pyrrolidin-3-yl]-4-(2-naphthyl)pyrimidin-2-amine;

N-{(3R)-1-[(4-methylphenyl)sulfonyl]pyrrolidin-3-yl}-4-(2-naphthyl)pyrimidin-2-amine;

(3R)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carbaldehyde;

N-[(3R)-1-(morpholin-4-ylcarbonyl)pyrrolidin-3-yl]-4-(2-naphthyl)pyrimidin-2-amine;

ethyl (3R)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxylate;

N-{[(3R)-1-acetylpyrrolidin-3-yl]methyl}-4-(2-naphthyl)pyrimidin-2-amine;

methyl (3R)-3-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)pyrrolidine-1-carboxylate;

(3R)-3-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)pyrrolidine-1-carbaldehyde;

N-{[(3S)-1-acetylpyrrolidin-3-yl]methyl}-4-(2-naphthyl)pyrimidin-2-amine;

methyl (3S)-3-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)pyrrolidine-1-carboxylate;

(3S)-3-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)pyrrolidine-1-carbaldehyde;

N-[(1-acetylpiperidin-4-yl)methyl]-4-(2-naphthyl)pyrimidin-2-amine;

N,N-dimethyl-4-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)piperidine-1-carboxamide;

N,N-diethyl-4-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)piperidine-1-carboxamide;

4-(2-naphthyl)-N-{[1-(pyrrolidin-1-ylcarbonyl)piperidin-4-yl]methyl}pyrimidin-2-amine;

N-{[1-(methylsulfonyl)piperidin-4-yl]methyl}-4-(2-naphthyl)pyrimidin-2-amine;

N,N-dimethyl-4-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)piperidine-1-sulfonamide;

4-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)piperidine-1-carboxamide;

N-ethyl-4-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)piperidine-1-carboxamide;

N-isopropyl-4-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)piperidine-1-carboxamide;

N-cyclohexyl-4-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)piperidine-1-carboxamide;

N-[(1-benzoylpiperidin-4-yl)methyl]-4-(2-naphthyl)pyrimidin-2-amine;

N-[(1-ethylpiperidin-4-yl)methyl]-4-(2-naphthyl)pyrimidin-2-amine;

N-[(1-benzylpiperidin-4-yl)methyl]-4-(2-naphthyl)pyrimidin-2-amine;

4-(2-naphthyl)-N-{[1-(phenylacetyl)piperidin-4-yl]methyl}pyrimidin-2-amine;

N-({1-[(4-methylphenyl)sulfonyl]piperidin-4-yl}methyl)-4-(2-naphthyl)pyrimidin-2-amine;

N-(trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)acetamide;

methyl (trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)carbamate;

N,N-dimethyl-N′

-(trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)urea;

N-ethyl-N′

-(trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)urea;

N,N-dimethyl-N′

-(trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)sulfamide;

N-(trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)methanesulfonamide;

4-methyl-N-(trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)benzenesulfonamide;

5-(dimethylamino)-N-(trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)naphthalene-1-sulfonamide;

4-cyano-N-(3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)benzamide;

N-(1-acetylpiperidin-4-yl)-4-(2-naphthyl)pyrimidin-2-amine;

N,N-dimethyl-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

N,N-diethyl-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

4-(2-naphthyl)-N-[1-(pyrrolidin-1-ylcarbonyl)piperidin-4-yl]pyrimidin-2-amine;

N-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]-4-(2-naphthyl)pyrimidin-2-amine;

N-[1-(methylsulfonyl)piperidin-4-yl]-4-(2-naphthyl)pyrimidin-2-amine;

N,N-dimethyl-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-sulfonamide;

4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

N-ethyl-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

N-isopropyl-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

N-cyclohexyl-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

N-(1-benzoylpiperidin-4-yl)-4-(2-naphthyl)pyrimidin-2-amine;

N-(1-acetylpiperidin-4-yl)-N-methyl-4-(2-naphthyl)pyrimidin-2-amine;

N-methyl-4-(2-naphthyl)-N-[1-(trifluoroacetyl)piperidin-4-yl]pyrimidin-2-amine;

N-(1-benzoylpiperidin-4-yl)-N-methyl-4-(2-naphthyl)pyrimidin-2-amine;

methyl 4-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxylate;

N,N-dimethyl-4-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

N-methyl-4-(2-naphthyl)-N-[1-(pyrrolidin-1-ylcarbonyl)piperidin-4-yl]pyrimidin-2-amine;

N,N-diethyl-4-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

N-ethyl-4-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

4-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

N-methyl-N-[1-(methylsulfonyl)piperidin-4-yl]-4-(2-naphthyl)pyrimidin-2-amine;

N-methyl-N-{1-[(4-methylphenyl)sulfonyl]piperidin-4-yl}-4-(2-naphthyl)pyrimidin-2-amine;

N-methyl-4-(2-naphthyl)-N-(1-pyrimidin-2-ylpiperidin-4-yl)pyrimidin-2-amine;

N-methyl-4-(2-naphthyl)-N-(1-propylpiperidin-4-yl)pyrimidin-2-amine;

2-(4-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidin-1-yl)acetamide;

N-methyl-4-(2-naphthyl)-N-{1-[2-(trityloxy)ethyl]piperidin-4-yl}pyrimidin-2-amine;

4-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboximidamide;

tert-butyl (3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)carbamate;

or

4-(2-naphthyl)-2-[4-(pyrrolidin-1-ylmethyl)piperidin-1-yl]pyrimidine.

43. A method of synthesizing a compound of claim 9 or 30, comprising:

reacting a compound of the Formula 4;