Method and system for evaluation of the hemodynamic model in depression for diagnosis and treatment
First Claim
1. A non-invasive method to determine the cerebral hemodynamics in a human subject with depression including, steps of:
- (a) obtaining a subject'"'"'s baseline percent carotid stenosis in the extracranial right and left carotid arteries using B-mode and Doppler measurements;
(b) obtaining the subject'"'"'s baseline mean blood flow velocity in cerebral arteries on both sides of the brain using transcranial Doppler ultrasound instrument;
(c) comparing the percent carotid stenosis in both right and left to normal limits;
(d) simultaneously with (c) determining if the percent carotid stenosis of one side is greater than the other;
(e) determining if mean blood flow velocity in the right or left anterior cerebral artery is lower than normal limits;
(f) simultaneously with (e) determining if the mean flow velocity of one side of the anterior cerebral artery is greater than the other;
(g) simultaneously with (f) determining if there was a right or left anterior cerebral artery hyperperfusion;
(h) simultaneously with (g) determining if there was a right or left anterior cerebral artery hypoperfusion;
(i) determining if mean blood flow velocity in the right or left posterior cerebral artery are lower than normal limits;
(j) simultaneously with (i) determining if mean blood flow velocity of one side of the posterior cerebral artery is greater than the other;
(k) simultaneously with (j) determining if there was a right or left posterior cerebral artery hypoperfusion;
(l) determining the DSM-IV score using the standard questionnaire;
(m) simultaneously with (l) determining if the DSM-IV score was greater than or equal to five; and
(n) simultaneously with (m) determining if the cerebral hemodynamic model could be associated with depression.
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Abstract
The present invention provides a method and system for determining the cerebral hemodynamic model for depression, using carotid duplex ultrasound to establish percent stenosis of the extracranial right and left internal carotid arteries and transcranial Doppler ultrasound instrument to measure mean flow velocity within the cerebral including the right and left internal carotid arteries, right and left middle cerebral arteries, right and left anterior cerebral arteries, right and left posterior cerebral arteries, and basilar artery. The percent carotid stenosis and the mean flow velocity values in cerebral arteries are used to determine the cerebral hemodynamic model associated with depression in men and women, respectively.
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Citations
20 Claims
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1. A non-invasive method to determine the cerebral hemodynamics in a human subject with depression including, steps of:
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(a) obtaining a subject'"'"'s baseline percent carotid stenosis in the extracranial right and left carotid arteries using B-mode and Doppler measurements; (b) obtaining the subject'"'"'s baseline mean blood flow velocity in cerebral arteries on both sides of the brain using transcranial Doppler ultrasound instrument; (c) comparing the percent carotid stenosis in both right and left to normal limits; (d) simultaneously with (c) determining if the percent carotid stenosis of one side is greater than the other; (e) determining if mean blood flow velocity in the right or left anterior cerebral artery is lower than normal limits; (f) simultaneously with (e) determining if the mean flow velocity of one side of the anterior cerebral artery is greater than the other; (g) simultaneously with (f) determining if there was a right or left anterior cerebral artery hyperperfusion; (h) simultaneously with (g) determining if there was a right or left anterior cerebral artery hypoperfusion; (i) determining if mean blood flow velocity in the right or left posterior cerebral artery are lower than normal limits; (j) simultaneously with (i) determining if mean blood flow velocity of one side of the posterior cerebral artery is greater than the other; (k) simultaneously with (j) determining if there was a right or left posterior cerebral artery hypoperfusion; (l) determining the DSM-IV score using the standard questionnaire; (m) simultaneously with (l) determining if the DSM-IV score was greater than or equal to five; and (n) simultaneously with (m) determining if the cerebral hemodynamic model could be associated with depression. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A non-invasive method and system to determine the cerebral hemodynamic model in a male subject with depression including, steps of:
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(a) obtaining a subject'"'"'s baseline percent carotid stenosis in the extracranial right and left carotid arteries using B-mode and Doppler measurements; (b) obtaining the subject'"'"'s baseline mean blood flow velocity in cerebral arteries on both sides of the brain using transcranial Doppler ultrasound instrument; (c) comparing the percent carotid stenosis in both right and left to normal limits; (d) simultaneously with (c) determining if the percent carotid stenosis of the right is greater than the left; (e) determining if mean blood flow velocity in the right anterior cerebral artery is lower than normal limits; (f) simultaneously with (e) determining if the mean flow velocity of the left anterior cerebral artery is greater than the right; (g) simultaneously with (f) determining if there was a right anterior cerebral artery hypoperfusion; (h) simultaneously with (g) determining if there was a left anterior cerebral artery hyperperfusion; (i) determining if mean blood flow velocity in the left posterior cerebral artery is lower than normal limits; (j) simultaneously with (i) determining if mean blood flow velocity of the right posterior cerebral artery is greater than the left; (k) simultaneously with (j) determining if there was a left posterior cerebral artery hypoperfusion; (l) determining the DSM-IV score using the standard questionnaire; (m) simultaneously with (l) determining if the DSM-IV score was greater than or equal to five; and (n) simultaneously with (m) determining if the cerebral hemodynamic model could be associated with depression in men. - View Dependent Claims (8, 9, 10, 11, 12, 13)
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14. A non-invasive method and system to determine the cerebral hemodynamic model in a female subject with depression including, steps of:
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(a) obtaining a subject'"'"'s baseline percent carotid stenosis in the extracranial right and left carotid arteries using B-mode and Doppler measurements; (b) obtaining the subject'"'"'s baseline mean blood flow velocity in cerebral arteries on both sides of the brain using transcranial Doppler ultrasound instrument; (c) comparing the percent carotid stenosis in both right and left to normal limits; (d) simultaneously with (c) determining if the percent carotid stenosis of the left is greater than the right; (e) determining if mean blood flow velocity in the left anterior cerebral artery is lower than normal limits; (f) simultaneously with (e) determining if the mean flow velocity of the right anterior cerebral artery is greater than the left; (g) simultaneously with (f) determining if there is a right anterior cerebral artery hyperperfusion; (h) simultaneously with (g) determining if there is a left anterior cerebral artery hypoperfusion; (i) determining if mean blood flow velocity in the right posterior cerebral artery is lower than normal limits; (j) simultaneously with (i) determining if mean blood flow velocity of the left posterior cerebral artery is greater than the right; (k) simultaneously with (j) determining if there was a right posterior cerebral artery hypoperfusion; (l) determining the DSM-IV score using the standard questionnaire; (m) simultaneously with (l) determining if the DSM-IV score was greater than or equal to five; and (n) simultaneously with (m) determining if the cerebral hemodynamic model was associated with depression in women. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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Specification