Analyte concentration detection devices and methods
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Accused Products
Abstract
Arrangements for the detection of the presence and/or concentration of an analyte in a sample of bodily fluid include diffuse transmission, diffuse reflection and edge or waveguide illumination arrangements. A vertical flow assay arrangement and/or technique is also disclosed, and includes a detection component that can be in the form of an array of optical detection elements. A number of assay pad constructions are described which may include at least one or more of the following components: a prefilter component, a reflective component, a membrane component, a reagent component, a mesh component, and a component to prevent lateral spreading.
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Citations
83 Claims
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1-58. -58. (canceled)
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59. An arrangement for use in detecting the presence or concentration of an analyte present in bodily fluid, the arrangement comprising:
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(a) an assay pad adapted to receive a sample of the bodily fluid, the assay pad containing a reagent; (b) at least one detector adapted to produce a signal indicative of a reaction between the analyte and the reagent; (c) electronics monitoring and interpreting the signals produced by the at least one detector to provide at least one of the following; (i) an estimate of the volume of the sample under analysis; and (ii) information about the kinetics of the reaction between the analyte and the reagent based at least in part on the time between signals. - View Dependent Claims (60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 71)
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72. A method useful in detecting the presence or concentration of an analyte present in bodily fluid, the method comprising:
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(a) introducing a sample of the bodily fluid onto an assay pad, the assay pad containing a reagent; (b) producing at least one signal upon a reaction between the analyte and the reagent, producing the at least one signal with at least one detector; (c) monitoring and interpreting the at least one signal to provide at least one of; (i) an estimate of the volume of the sample under analysis; and (ii) information about the kinetics of the reaction between the analyte and the reagent based at least in part on the time between signals. - View Dependent Claims (73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83)
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Specification