Planar implant

• US 20090054995A1
• Filed: 07/23/2008
• Published: 02/26/2009
• Est. Priority Date: 07/24/2007
• Status: Active Grant

• Current Assignee: Aesculap AG (Lonza Group AG)
• Original Assignee: Aesculap AG (Lonza Group AG)
• Inventors: Blender, Bernd, Odermatt, Erich, Wegmann, Juergen
• Granted Patent: US 9,370,604 B2
• Time in Patent Office: Days
• US Class Current: 623/23.720
• CPC Class Codes: A61F 13/00 Bandages or dressings radioactive dressings A61N5/1029; Absorbent pads
• CPC Class Codes: A61F 13/01029 made of multiple layers
• CPC Class Codes: A61F 2/02 Prostheses implantable into the body closure means for urethra or rectum or for artificial body openings therefor A61F2/0004
• CPC Class Codes: A61L 26/0033 Collagen
• CPC Class Codes: A61L 26/0038 Gelatin
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/3604 characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
• CPC Class Codes: A61L 27/3675 Nerve tissue, e.g. brain, spinal cord, nerves, dura mater
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges

Abstract

A planar implant for replacement of biological tissues includes a layered structure including

• • a) a lyophilized pericardium layer of biological origin, and
  • b) at least one sponge-like layer of lyophilized extracellular protein.

Claims

1. A planar implant for replacement of biological tissues comprising a layered structure comprising:

a) a lyophilized pericardium layer of biological origin, and

b) at least one sponge-like layer of lyophilized extracellular protein.

2. The planar implant according to claim 1, wherein the extracellular protein is collagen.

3. The planar implant according to claim 1, wherein the extracellular protein is gelatin.

4. The planar implant according to claim 1, wherein the extracellular protein is uncrosslinked.

5. The planar implant according to claim 1, wherein the pericardium layer is covered on one side with the sponge-like layer.

6. The planar implant according to claim 1, wherein a surface of the pericardium layer directed toward the sponge-like layer is roughened.

7. The planar implant according to claim 1, wherein the sponge-like layer is lyophilized as substrate onto the pericardium layer.

8. The planar implant according to claim 1, wherein the sponge-like layer is chemically fixed to the pericardium layer.

9. The planar implant according to claim 1, wherein the implant has a thickness of between 1 and 10 mm.

10. The planar implant according to claim 1, wherein the pericardium layer has a thickness of between 0.1 and 4 mm.

11. The planar implant according to claim 1, wherein the sponge-like layer has a layer thickness of 1 to 10 mm.

12. The planar implant according to claim 1, wherein the implant has a weight per unit area of 80 to 480 g/m².

13. The planar implant according to claim 1, wherein the pericardium layer has a weight per unit area of 50 to 180 g/m².

14. The planar implant according to claim 1 wherein the sponge-like layer has a weight per unit area of 30 to 300 g/m².

15. The planar implant according to claim 1, having a density of 10 to 50 g/dm³.

16. The planar implant according to claim 1, wherein the pericardium layer in the implant has protruding edges.

17. The planar implant according to claim 1, wherein the sponge-like layer in the implant has protruding edges.

18. The planar implant according to claim 1, wherein the sponge-like layer is formed only partially on the pericardium layer.

19. The planar implant according to claim 1, wherein the sponge-like layer contains a water-soluble biocompatible organic.

20. The planar implant according to claim 1, wherein the sponge-like layer has a pH value of <

4 upon addition of water.

21. The planar implant according to claim 1, wherein the sponge-like layer contains active substances.

22. The planar implant according to claim 1, wherein the sponge-like layer has a liquid absorption capacity corresponding to 20 to 60 times its own weight.

23. The planar implant according to claim 1, wherein the sponge-like layer can be completely wetted with water within a period of <

100 seconds.

24. The planar implant according to claim 1 that replaces and/or closes the dura mater.

26. A method of treating tissue defects comprising stopping or sealing leaking of liquid and/or air in a portion of a patient with the implant according to claim 1.

25. A method for producing an implant comprising lyophilizing and connecting a pericardium layer and at least one layer of extracellular protein to each other.