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HUMAN MONOCLONAL ANTIBODIES TO BE PROGRAMMED DEATH LIGAND 1 (PD-L1)

  • US 20090055944A1
  • Filed: 06/30/2006
  • Published: 02/26/2009
  • Est. Priority Date: 07/01/2005
  • Status: Active Grant
First Claim
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1. An isolated human monoclonal antibody, or an antigen-binding portion thereof, wherein the antibody specifically binds to human PD-L1 and wherein the antibody exhibits at least one of the following properties:

  • (a) binds to human PD-L1 with a KD of 1×

    10

    7
    M or less;

    (b) increases T-cell proliferation in a mixed lymphocyte reaction (MLR) assay;

    (c) increases interferon-γ

    production in an MLR assay;

    or(d) increases interleukin-2 (IL-2) secretion in an MLR assay.

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