Devices and methods for biochip multiplexing
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Accused Products
Abstract
The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.
61 Citations
39 Claims
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1-14. -14. (canceled)
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15. A multiplex detection device, comprising:
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a plurality of stations each for housing a biochip and each independently addressable; a plurality of biochips each in a station and each comprising; i) an array of working electrodes at least some of which comprise a capture binding ligand for detecting analyte in an aqueous sample; ii) one or more reference electrodes; iii) one or more auxiliary electrodes; and iv) interconnects for electrical communication with each of said electrodes; controls for inputting signal to said electrodes; a detector for detecting output signal from said electrodes; one or more pumps for circulating aqueous analyte samples on said biochips; and one or more processors for amplifying analyte signal or filtering background. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 32, 33, 34, 35, 36, 37, 38, 39)
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28. A multiplex detection device, comprising:
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a plurality of stations each for housing a biochip and each independently addressable; a plurality of biochips each in a station and each comprising; i) an array of working electrodes at least some of which comprise a capture binding ligand for detecting analyte in an aqueous sample; ii) one or more reference electrodes; iii) one or more auxiliary electrodes; iv) interconnects for electrical communication with each of said electrodes; and v) one or more aqueous buffer or reaction chambers; controls for inputting signal to said electrodes; a detector for detecting output signal from said electrodes; one or more pumps for circulating aqueous analyte samples on said biochips; and one or more processors for amplifying analyte signal or filtering background; one or more on-chip aqueous buffer or reaction mixture chambers.
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29. A multiplex detection device, comprising:
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a plurality of stations each for housing a biochip and each independently addressable; a plurality of biochips each in a station and each comprising; i) an array of working electrodes at least some of which comprise a capture binding ligand for detecting analyte in an aqueous sample; ii) one or more reference electrodes; iii) one or more auxiliary electrodes; iv) interconnects for electrical communication with each of said electrodes; and v) one or more aqueous buffer or reaction chambers; wherein said plurality of biochips are configured to circulate and recirculate an aqueous analyte sample across said array of working electrodes; controls for inputting signal to said electrodes; a detector for detecting output signal from said electrodes; one or more pumps for circulating aqueous analyte samples on said biochips; and one or more processors for amplifying analyte signal or filtering background; one or more on-chip aqueous buffer or reaction mixture chambers.
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30. A multiplex detection device, comprising:
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a plurality of stations each for housing a biochip and each independently addressable; a plurality of biochips each in a station and each comprising; i) an array of working electrodes housed serially in an elongated channel and at least some of which comprise a capture binding ligand for detecting analyte in an aqueous sample; ii) one or more reference electrodes; iii) one or more auxiliary electrodes; iv) interconnects for electrical communication with each of said electrodes; and v) one or more aqueous buffer or reaction chambers; wherein said plurality of biochips are configured to circulate and recirculate an aqueous analyte sample across said array of working electrodes; controls for inputting signal to said electrodes; a detector for detecting output signal from said electrodes; one or more pumps for circulating aqueous analyte samples on said biochips; and one or more processors for amplifying analyte signal or filtering background;
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31. A multiplex detection device, comprising:
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a plurality of stations each for housing a biochip and each independently addressable; a plurality of biochips each in a station and each comprising; i) an array of working electrodes at least some of which comprise a capture binding ligand for detecting analyte in an aqueous sample; ii) one or more reference electrodes; iii) one or more auxiliary electrodes; and iv) interconnects for electrical communication with each of said electrodes; controls for inputting signal to said electrodes; a detector for detecting output signal from said electrodes; one or more pumps for circulating aqueous analyte samples on said biochips; one or more processors for amplifying analyte signal or filtering background; and thermocontrols for controlling the temperature of said biochips.
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Specification