Pharmaceutical Compositions Comprising an Anti-Teratogenic Compound and Applications of the Same
First Claim
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1. A pharmaceutical composition comprising an anti-neoplastic agent and an anti-teratogenic agent.
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Abstract
Pharmaceutical compositions comprising anti-teratogenic agents are disclosed. Additionally, pharmaceutical compositions comprising anti-neoplastic agents and anti-teratogenic agents are disclosed. Methods of assessing the teratogenicity of a compound are disclosed. The present invention further comprises applications of the aforementioned compositions and methods.
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Citations
31 Claims
- 1. A pharmaceutical composition comprising an anti-neoplastic agent and an anti-teratogenic agent.
- 9. A pharmaceutical composition for blocking the teratogenicity of an anti-neoplastic agent comprising an agent that activates the Wnt signaling pathway downstream of the Wnt ligand-receptor interaction.
- 16. A method of inhibiting the teratogenicity of an anti-neoplastic agent comprising administering a pharmaceutical composition comprising an agent that activates the Wnt signaling pathway downstream of the Wnt ligand-receptor interaction.
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23. A method of assessing the teratogenicity of a compound comprising:
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(a) administering the compound to a cell; and (b) observing whether there is activation of the Wnt signaling pathway downstream of the Wnt ligand-receptor interaction in comparison to an untreated cell.
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- 24. A method of treating a mammalian subject comprising administering to said mammalian subject an effective amount of a pharmaceutical composition comprising an anti-neoplastic agent and an anti-teratogenic agent.
Specification